Chemical Compound Review:
Triazene triazene
Synonyms:
triaz-1-ene, AG-D-97252, CHEBI:35468, CHEBI:72573, CTK0H6600, ...
- O6-alkylguanine-DNA alkyltransferase attenuates triazene-induced cytotoxicity and tumor cell immunogenicity in murine L1210 leukemia. Graziani, G., Faraoni, I., Grohmann, U., Bianchi, R., Binaglia, L., Margison, G.P., Watson, A.J., Orlando, L., Bonmassar, E., D'Atri, S. Cancer Res. (1995)
- Multiple point mutations in an endogenous retroviral gene confer high immunogenicity on a drug-treated murine tumor. Grohmann, U., Puccetti, P., Belladonna, M.L., Fallarino, F., Bianchi, R., Binaglia, L., Sagakuchi, K., Mage, M.G., Appella, E., Fioretti, M.C. J. Immunol. (1995)
- Potential antitumor agents. 22. Latentiated congeners of the 4'-(9-acridinylamino)methanesulfonanilides. Atwell, G.J., Cain, B.F., Denny, W.A. J. Med. Chem. (1977)
- Antitumor imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one , a novel broad-spectrum antitumor agent. Stevens, M.F., Hickman, J.A., Stone, R., Gibson, N.W., Baig, G.U., Lunt, E., Newton, C.G. J. Med. Chem. (1984)
- In vitro infection of leukemic bone marrow with HTLV-I generates immortalized cell lines expressing T or myeloid cell phenotype. Giuliani, A., Vernole, P., D'Atri, S., Del Poeta, G., D'Onofrio, C., Faraoni, I., Greiner, J.W., Bonmassar, E., Graziani, G. Leukemia (1995)
- Effects of postsurgical immunotherapy with PGM in mice bearing Lewis lung carcinoma treated with p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt. Sava, G., Zorzet, S., Perissin, L., Lassiani, L., Tomasic, J. Methods and findings in experimental and clinical pharmacology. (1985)
- Effect of alpha-D-mannopyranosylmethyl-p-nitrophenyltriazene on hepatic degradation and processing of the N-linked oligosaccharide chains of alpha 1-acid glycoprotein. Docherty, P.A., Kuranda, M.J., Aronson, N.N., BeMiller, J.N., Myers, R.W., Bohn, J.A. J. Biol. Chem. (1986)
- Deciphering the mechanistic dichotomy in the cyclization of 1-(2-ethynylphenyl)-3,3-dialkyltriazenes: competition between pericyclic and pseudocoarctate pathways. Kimball, D.B., Weakley, T.J., Herges, R., Haley, M.M. J. Am. Chem. Soc. (2002)
- Mutagenicity of dimethyl heteroaromatic triazenes in the Ames test: the role of hydrophobicity and electronic effects. Shusterman, A.J., Debnath, A.K., Hansch, C., Horn, G.W., Fronczek, F.R., Greene, A.C., Watkins, S.F. Mol. Pharmacol. (1989)
- Synthesis and antitumor activity of methyltriazene prodrugs simultaneously releasing DNA-methylating agents and the antiresistance drug O(6)-benzylguanine. Wanner, M.J., Koch, M., Koomen, G.J. J. Med. Chem. (2004)
- In vitro antitumor activity of 3'-desamino-3'(2-methoxy-4-morpholinyl) doxorubicin on human melanoma cells sensitive or resistant to triazene compounds. Alvino, E., Gilberti, S., Cantagallo, D., Massoud, R., Gatteschi, A., Tentori, L., Bonmassar, E., D'Atri, S. Cancer Chemother. Pharmacol. (1997)
- In vitro combined effects of a triazene compound and interferon-beta on natural immunity against lymphoblastoid cells: studies at effector and target cell level. Bonmassar, L., D'Atri, S., Turriziani, M., Giuliani, A. Immunopharmacology and immunotoxicology. (1994)
- Two spin labeled triazenes: relationship between biochemical and biological activities. Gadjeva, V.G. International journal of pharmaceutics. (2002)
- Malignant melanoma--future prospects. Lugović, L., Situm, M., Kos, L. Acta dermatovenerologica Croatica : ADC / Hrvatsko dermatolosko drustvo. (2005)
- Efficient synthesis of sulfonic, phosphoric, and phosphinic esters employing alkylating polymer-bound reagents. Vignola, N., Dahmen, S., Enders, D., Bräse, S. Journal of combinatorial chemistry. (2003)
- Pyrazole derivatives. 5. Synthesis and antineoplastic activity of 3-(2-chloroethyl)-3,4-dihydro-4-oxopyrazolo[5,1-d]-1,2,3, 5-tetrazine-8-carboxamide and related compounds. Cheng, C.C., Elslager, E.F., Werbel, L.M., Priebe, S.R., Leopold, W.R. J. Med. Chem. (1986)
- Triazene compounds induce apoptosis in O6-alkylguanine-DNA alkyltransferase deficient leukemia cell lines. Tentori, L., Graziani, G., Gilberti, S., Lacal, P.M., Bonmassar, E., D'Atri, S. Leukemia (1995)
- Base sequence selectivity in the alkylation of DNA by 1,3-dialkyl-3-acyltriazenes. Kroeger Smith, M.B., Taneyhill, L.A., Michejda, C.J., Smith, R.H. Chem. Res. Toxicol. (1996)
- Preparation and properties of (R)-(-)-1-azabicyclo[2.2.2]oct-3-yl- (R)-(+)-alpha-hydroxy-alpha-(4-[125I]iodophenyl)-alpha-phenyl acetate and (R)-(-)-1-azabicyclo[2.2.2]oct-3-yl-(S)-(-)-alpha-hydroxy-alpha- (4-[125I]iodophenyl)-alpha-phenyl acetate as potential radiopharmaceuticals. Cohen, V.I., Rzeszotarski, W.J., Gibson, R.E., Fan, L.H., Reba, R.C. Journal of pharmaceutical sciences. (1989)
- Specific inactivation of lysosomal glycosidases in living fibroblasts by the corresponding glycosylmethyl-p-nitrophenyltriazenes. Van Diggelen, O.P., Galjaard, H., Sinnott, M.L., Smith, P.J. Biochem. J. (1980)
- Mutation of the mismatch repair gene hMSH2 and hMSH6 in a human T-cell leukemia line tolerant to methylating agents. Levati, L., Marra, G., Lettieri, T., D'Atri, S., Vernole, P., Tentori, L., Lacal, P.M., Pagani, E., Bonmassar, E., Jiricny, J., Graziani, G. Genes Chromosomes Cancer (1998)
- Drug-mediated changes in the susceptibility of human lymphoblastoid B cells to NK-mediated cytolysis: studies with a triazene compound. D'Atri, S., Bonmassar, L., Turriziani, M., Giuliani, A. Journal of chemotherapy (Florence, Italy) (1994)
- Metabolism of 1,3-di-(4-[N-(4,6-dimethyl-2-pyrimidinyl)sulphamoyl] phenyl)triazene (DDPSPT) in the rat. Paulson, G.D., Feil, V.J., McDonald, J.J. Xenobiotica (1990)
- Ear malformations in the mouse embryo following maternal administration of triazene, with clinical implications. Louryan, S., Heymans, O., Goffard, J.C. Surgical and radiologic anatomy : SRA. (1995)
- Evidence for an unstable DNA adduct from N-nitroso-N-methylaniline. Koepke, S.R., Kroeger-Koepke, M.B., Michejda, C.J. Chem. Res. Toxicol. (1990)
- Cyclization of 1-(2-alkynylphenyl)-3,3-dialkyltriazenes: a convenient, high-yield synthesis of substituted cinnolines and isoindazoles. Kimball, D.B., Weakley, T.J., Haley, M.M. J. Org. Chem. (2002)
- Formation of triazene from sulphonamide and nitrite in acidic solution. Haraguchi, K., Masuda, Y. Food Chem. Toxicol. (1986)
- Modulating effect of new potential antimelanomic agents, spin-labeled triazenes and nitrosoureas on the DOPA-oxidase activity of tyrosinase. Gadjeva, V., Zheleva, A., Raikova, E. Cancer Biochem. Biophys. (1999)
- O(6)-(4-Bromothenyl)guanine (PaTrin-2), a novel inhibitor of O(6)-alkylguanine DNA alkyl-transferase, increases the inhibitory activity of temozolomide against human acute leukaemia cells in vitro. Turriziani, M., Caporaso, P., Bonmassar, L., Buccisano, F., Amadori, S., Venditti, A., Cantonetti, M., D'Atri, S., Bonmassar, E. Pharmacol. Res. (2006)
- Structural studies on bioactive compounds. 28. Selective activity of triazenyl-substituted pyrimethamine derivatives against Pneumocystis carinii dihydrofolate reductase. Stevens, M.F., Phillip, K.S., Rathbone, D.L., O'Shea, D.M., Queener, S.F., Schwalbe, C.H., Lambert, P.A. J. Med. Chem. (1997)
- Triazene metabolism. III. In vitro cytotoxicity towards M21 cells and in vivo antitumour activity of the proposed metabolites of the antitumour 1-aryl-3,3-dimethyltriazenes. Kohlsmith, D.J., Vaughan, K., Luner, S.J. Can. J. Physiol. Pharmacol. (1984)
- Active-site-directed inactivation of Aspergillus oryzae beta-galactosidase with beta-D-galactopyranosylmethyl-p-nitrophenyltriazene. Mega, T., Nishijima, T., Ikenaka, T. J. Biochem. (1990)
- X-ray studies on anti-tumour triazenes. Structures of 1-(4-carbamoylphenyl)-3,3-dimethyltriazene 1-oxide and 3,3-dimethyl-1-(4-nitrophenyl)triazene. Neidle, S., Wilman, D.E. Acta Crystallogr., B (1992)
- In vivo autoradiography of radioiodinated (R)-3-quinuclidinyl (S)-4-iodobenzilate [(R, S)-IQNB] and (R)-3-quinuclidinyl (R)-4-iodobenzilate [(R,R)-IQNB]. Comparison of the radiolabelled products of a novel tributylstannyl precursor with those of the established triazene and exchange methods. Sood, V.K., Lee, K.S., Boulay, S.F., Rayeq, M.R., McRee, R.C., Cohen, E.I., Zeeberg, B.R., He, X.S., Weinberger, D.R., Rice, K., Reba, R.C. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. (1997)