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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Growth Disorders

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Disease relevance of Growth Disorders


High impact information on Growth Disorders


Chemical compound and disease context of Growth Disorders


Biological context of Growth Disorders


Anatomical context of Growth Disorders


Gene context of Growth Disorders

  • A precise understanding of the actions of SOCS proteins in GH signalling may offer new opportunities for therapeutic intervention in growth disorders and other conditions involving GH action [18].
  • This suggests that the growth disorders in this group of children might be due to a defect in a DNA region regulating expression of the GHR and IGF1 genes or genes involved in their regulation [19].
  • Thus, TrkB agonists and antagonists deserve exploration as novel hair growth-modulatory drugs for the management of common hair growth disorders [20].
  • Of the growth disorders that involve excessive growth, many could be attributable to overexpression of IGF2 [21].
  • These findings strongly support TRPV1 as a significant novel player in human hair growth control, underscore the physiological importance of TRPV1 in human skin beyond nociception, and identify TRPV1 as a promising, novel target for pharmacological manipulations of epithelial growth disorders [22].

Analytical, diagnostic and therapeutic context of Growth Disorders

  • This work investigated in rats whether passive immunization against the endogenous GHRF in the early postnatal period led to permanent alterations of somatotropic function, similar to those observed in several human growth disorders, e.g. constitutional growth delay (CGD) [23].
  • In order to evaluate the potential use of IGF monitoring in children treated with GH, a cross-sectional study has been carried in 215 children and adolescents (134 with GH deficiency (GHD), 54 with Turner syndrome (TS) and 27 with non-GHD growth disorders) treated with GH for 0.2-13.7 years [24].


  1. Control of murine hair follicle regression (catagen) by TGF-beta1 in vivo. Foitzik, K., Lindner, G., Mueller-Roever, S., Maurer, M., Botchkareva, N., Botchkarev, V., Handjiski, B., Metz, M., Hibino, T., Soma, T., Dotto, G.P., Paus, R. FASEB J. (2000) [Pubmed]
  2. No evidence for uniparental disomy as a common cause of Sotos syndrome. Smith, M., Fullwood, P., Qi, Y., Palmer, S., Upadhyaya, M., Cole, T. J. Med. Genet. (1997) [Pubmed]
  3. Growth disorders and homocysteine metabolism. McCully, K.S. Ann. Clin. Lab. Sci. (1975) [Pubmed]
  4. Head and neck cancer associated with Bloom's syndrome. Berkower, A.S., Biller, H.F. Laryngoscope (1988) [Pubmed]
  5. Abnormal expression of the p53 tumor suppressor gene in the conjunctiva of patients with pterygium. Tan, D.T., Lim, A.S., Goh, H.S., Smith, D.R. Am. J. Ophthalmol. (1997) [Pubmed]
  6. The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder. Kallijärvi, J., Avela, K., Lipsanen-Nyman, M., Ulmanen, I., Lehesjoki, A.E. Am. J. Hum. Genet. (2002) [Pubmed]
  7. STAT5 signaling in sexually dimorphic gene expression and growth patterns. Davey, H.W., Wilkins, R.J., Waxman, D.J. Am. J. Hum. Genet. (1999) [Pubmed]
  8. Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human. Monk, D., Sanches, R., Arnaud, P., Apostolidou, S., Hills, F.A., Abu-Amero, S., Murrell, A., Friess, H., Reik, W., Stanier, P., Constância, M., Moore, G.E. Hum. Mol. Genet. (2006) [Pubmed]
  9. Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same mark. Arnaud, P., Monk, D., Hitchins, M., Gordon, E., Dean, W., Beechey, C.V., Peters, J., Craigen, W., Preece, M., Stanier, P., Moore, G.E., Kelsey, G. Hum. Mol. Genet. (2003) [Pubmed]
  10. PTEN: tumour suppressor, multifunctional growth regulator and more. Goberdhan, D.C., Wilson, C. Hum. Mol. Genet. (2003) [Pubmed]
  11. Pubertal growth and growth hormone secretion. Martha, P.M., Reiter, E.O. Endocrinol. Metab. Clin. North Am. (1991) [Pubmed]
  12. LPS-induced lung injury in neonatal rats: changes in gelatinase activities and consequences on lung growth. Franco, M.L., Waszak, P., Banalec, G., Levame, M., Lafuma, C., Harf, A., Delacourt, C. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  13. Growth factors in the pathogenesis of renovascular complications of diabetes mellitus. Woolf, A.S., Bosch, R.J., Fine, L.G. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. (1992) [Pubmed]
  14. Extra-colonic manifestations of familial adenomatous polyposis. Jagelman, D.G. Oncology (Williston Park, N.Y.) (1991) [Pubmed]
  15. Physiologic and clinical relevance of the insulin-like growth factor binding proteins. Cohen, P., Rosenfeld, R.G. Curr. Opin. Pediatr. (1994) [Pubmed]
  16. Thyroid hormones regulate hypertrophic chondrocyte differentiation and expression of parathyroid hormone-related peptide and its receptor during endochondral bone formation. Stevens, D.A., Hasserjian, R.P., Robson, H., Siebler, T., Shalet, S.M., Williams, G.R. J. Bone Miner. Res. (2000) [Pubmed]
  17. Detection of human growth hormone receptors on IM-9 cells and peripheral blood mononuclear cell subsets by flow cytometry: correlation with growth hormone-binding protein levels. Rapaport, R., Sills, I.N., Green, L., Barrett, P., Labus, J., Skuza, K.A., Chartoff, A., Goode, L., Stene, M., Petersen, B.H. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  18. Suppressors of cytokine signalling and regulation of growth hormone action. Greenhalgh, C.J., Alexander, W.S. Growth Horm. IGF Res. (2004) [Pubmed]
  19. Analysis of the human growth hormone receptor and IGF-I coding sequences in children with growth disorders. Obrepalska-Steplowska, A., Kedzia, A., Goździcka-Józefiak, A., Jakubowicz, M., Korman, E. Journal of pediatric endocrinology & metabolism : JPEM. (2003) [Pubmed]
  20. A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control. Botchkarev, V.A., Botchkareva, N.V., Welker, P., Metz, M., Lewin, G.R., Subramaniam, A., Bulfone-Paus, S., Hagen, E., Braun, A., Lommatzsch, M., Renz, H., Paus, A.R. FASEB J. (1999) [Pubmed]
  21. Insulin-like growth factor 2 and overgrowth: molecular biology and clinical implications. Morison, I.M., Reeve, A.E. Molecular medicine today. (1998) [Pubmed]
  22. A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control. Bodó, E., Bíró, T., Telek, A., Czifra, G., Griger, Z., Tóth, B.I., Mescalchin, A., Ito, T., Bettermann, A., Kovács, L., Paus, R. Am. J. Pathol. (2005) [Pubmed]
  23. Deprivation of growth hormone-releasing hormone early in the rat's neonatal life permanently affects somatotropic function. Cella, S.G., Locatelli, V., Mennini, T., Zanini, A., Bendotti, C., Forloni, G.L., Fumagalli, G., Arce, V.M., de Gennaro Colonna, V., Wehrenberg, W.B. Endocrinology (1990) [Pubmed]
  24. IGF-I and IGF-binding protein-3 measurements on filter paper blood spots in children and adolescents on GH treatment: use in monitoring and as markers of growth performance. Das, U., Whatmore, A.J., Khosravi, J., Wales, J.K., Butler, G., Kibirige, M.S., Diamandi, A., Jones, J., Patel, L., Hall, C.M., Price, D.A., Clayton, P.E. Eur. J. Endocrinol. (2003) [Pubmed]
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