Disease relevance of Nonlinear Dynamics

• We sought to determine whether new methods of analyzing RR interval variability based on nonlinear dynamics and fractal analysis may help to detect subtle abnormalities in RR interval behavior before the onset of life-threatening arrhythmias [1].
• We applied nonlinear analysis to the results of electroencephalography (EEG) in a pilocarpine-induced status epilepticus (SE) model to characterize nonlinear dynamics according to SE phase [2].

High impact information on Nonlinear Dynamics

• These results are integrated into a nonlinear model for mammalian NMD involving alternative routes of entry that converge at a common requirement of UPF1 [3].
• We investigated the hypothesis by applying a battery of tests originally developed for nonlinear time series analysis and chaos theory to EEG data collected from 32 men who had participated in an ethanol/placebo challenge protocol [4].
• The growth rate measurements for the air/SF6 and air/CO2 cases are in excellent agreement with the nonlinear model of Sadot et al. coupled with a reduction factor suggested by Rikanati et al [5].
• This review describes evidence in support of nonlinear models and functional roles of TGF-beta signaling in mediating apoptosis and epithelial-to-mesenchymal transdifferentiation (EMT) in chronic progressive renal disease [6].
• RESULTS: Deviations from single-hit kinetics were frequently observed in the HTL assays and a nonlinear model was therefore used for analysis [7].

Biological context of Nonlinear Dynamics

• The dynamics of N-methyl-D-aspartate receptor blockade-induced transitions between two types of intracellularly recorded spontaneous membrane potential oscillation from cat thalamic neurons have been studied using non-linear dynamics techniques [8].
• Ethanol pharmacokinetics in white women: nonlinear model fitting versus zero-order elimination analyses [9].
• Nonlinear dynamics in clinical pharmacology: the paradigm of cortisol secretion and suppression [10].
• OBJECTIVE: To study the beta-blocking effect of propranolol on heart rate and arterial blood pressure fluctuations in healthy subjects using linear methods and a set of nonlinear models [11].
• The model is a nonlinear dynamic contact problem that incorporates a three-dimensional, linear elastic, finite-element representation of a single vocal fold, a rigid midline surface, and quasistatic air pressure boundary conditions [12].

Anatomical context of Nonlinear Dynamics

• 1. Randomly modulated light stimuli were used to characterize the nonlinear dynamic properties of the synapse between photoreceptors and large monopolar neurons (LMC) in the fly retina [13].
• METHODS: A combined method consisting of structural MRI, multichannel magnetoencephalography (MEG) and the non-linear dynamics was applied for the detection of subthreshold interictal activity in temporal lobe epilepsy [14].
• The pharmacokinetic behaviors of 5-FU in plasma and pancreatic juice fitted a nonlinear model [15].

Associations of Nonlinear Dynamics with chemical compounds

• A noncompartment model based on chaos theory was used for calculating fractal dimension, which is a parameter for heterogeneity [16].
• Detecting changes in neuronal activities induced by N-methyl-D-aspartate receptor blockade using non-linear dynamics techniques [8].
• A nonlinear model relating the rate of increase in light emission after salicylate exposure to microbial density successfully predicted growth over 4 orders of magnitude (r(2) = 0.95) [17].
• The pharmacokinetic parameters for both ampicillin and sulbactam were calculated by computer-based two-compartment nonlinear model [18].
• Linear versus nonlinear models for hemoglobin adduct formation by acrylamide and its metabolite glycidamide: implications for risk estimation [19].

Gene context of Nonlinear Dynamics

• RESULTS: In the non-linear model, possession of an APOE epsilon4 allele related to earlier and faster cognitive decline, but possession of an APOE epsilon2 related to slower decline [20].
• METHODS: Based on a 2-compartment nonlinear model, regional ASGP receptor amount could be calculated from total liver ASGP receptor amount (Ro) and regional GSA uptake at a specific time [21].
• APOE alleles predict the rate of cognitive decline in Alzheimer disease: a nonlinear model [20].
• However, high resolution recording of these parameters and analysis of the data by non-linear dynamics revealed significant alterations in cardiovascular variability in Mas-deficient animals [22].
• The main source of the nonlinear dynamics is the reciprocal effect of AMP on the activities of phosphofructokinase and fructose 1,6-bisphosphatase [23].

Analytical, diagnostic and therapeutic context of Nonlinear Dynamics

• Tamoxifen treatment failure in cancer and the nonlinear dynamics of TGFbeta [24].

References