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MeSH Review

Sex Offenses

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Disease relevance of Sex Offenses

  • RESULTS: White subjects with binge eating disorder reported significantly higher rates of sexual abuse, physical abuse, bullying by peers, and discrimination than healthy comparison subjects [1].
  • HIV prevalence was associated with female gender; history of sexual abuse; engaging in survival sex; injecting heroin daily; injecting speedballs (a mixture of heroin and cocaine) daily; and having numerous lifetime sexual partners [2].
  • We re-analyzed data from a previous study of 100 women scheduled for diagnostic laparoscopy (50 for chronic pain, 50 for tubal ligation or infertility evaluation) who received structured, physician-administered psychiatric and sexual abuse interviews [3].
  • Compared to other participants, these women reported less education and higher rates of incarceration in the past year, sexually transmitted diseases, childhood sexual abuse, partner abuse, and current regular crack/cocaine and alcohol use [4].

Psychiatry related information on Sex Offenses


High impact information on Sex Offenses

  • RESULTS--A three-question Abuse Assessment Screen detected a 17% (1/6) prevalence of physical or sexual abuse during pregnancy, which is more than double all previous published reports [10].
  • Physical and sexual abuse, salivary cortisol, and neurologic correlates of violent criminal behavior in female prison inmates [11].
  • Three studies have documented the efficacy of providing trauma-focused, cognitive-behavioral therapy (TF-CBT) to symptomatic children within 1-6 months of experiencing sexual abuse [12].
  • Within the group of patients with BPD, the net prolactin response showed a high inverse correlation with the frequency of the physical (r = -.77) and sexual abuse (r = -.60) [13].
  • A higher frequency of prior sexual abuse has been suspected in NES, although no prospective controlled study has compared patients with NES and epilepsy [14].

Chemical compound and disease context of Sex Offenses

  • No difference between groups was observed for compliance with orlistat, childhood sexual abuse, relationships with parents, history of bulimia nervosa, rate of band inflation or preoperative BMI [15].

Biological context of Sex Offenses

  • The most frequently reported types of sexual harassment perpetrated by both employer and patient were, as defined by Cooper, "aesthetic appreciation" and "active mental groping," followed by "social touching" and "sexual abuse," with "ultimate threat" reported least [16].
  • Whereas the female profile suggested that early and unprotected sex were the only reliable predictors, HIV-positive male subjects had larger numbers of partners, engaged in more risky sexual behaviors, were more likely to have experienced sexual abuse before and during adolescence, and were more likely to have used cocaine during their adolescence [17].
  • RESULTS: Compared with the women without PMDD, only the group of women with PMDD with sexual abuse showed greater variance in both cycle phases in thyroid-stimulating hormone concentrations and greater luteal phase variance in free and total thyroxine (T4) and reverse tri-iodothyronine (T3) [18].

Anatomical context of Sex Offenses

  • These results suggest PMDD women with and without a history of sexual abuse respond differently to a clonidine challenge in measures reflecting autonomic nervous system functioning, indicating that abuse may modify presynaptic alpha2-AR function in PMDD [19].
  • CONCLUSIONS: These results suggest increased conversion of T4 to T3 and increased binding of thyroid hormones in women with PMDD with previous sexual abuse [18].

Associations of Sex Offenses with chemical compounds

  • Re-experienced sexual abuse as 'side effect' or cure following intravenous 2-chloroprocaine: comments on Phero et al., Pain, 43 (1990) 349-352 [20].
  • The ratio of growth hormone response to clonidine and L-dopa challenge was compared in 74 boys: 15 with purported physical abuse, 7 with purported sexual abuse, 13 normal controls, and 39 psychiatric controls [21].
  • Toluidine blue in the detection of perineal lacerations in pediatric and adolescent sexual abuse victims [22].
  • Sexual abuse, another hidden pediatric problem: the 1977 C. Anderson Aldrich lecture [23].
  • PATIENTS: A 57-yr-old man who misperceived rectal intubation as sexual assault while receiving intravenous lorazepam for sedation; a 31-yr-old woman who misinterpreted a perineal bed bath as sexual abuse while receiving lorazepam and fentanyl [24].

Gene context of Sex Offenses

  • Sexual abuse and physical neglect are more commonly reported by females with ADHD [25].
  • This article reviews recent studies of the role of childhood sexual abuse in the subsequent development of major depressive disorder, and the biological and psychosocial mechanisms by which early stressors may contribute to adult-onset depression in women [26].
  • Early-life adversity, such as physical or sexual abuse during childhood, results in long-lasting changes in the CRF-mediated stress response and a greatly increased risk of depression in genetically predisposed persons [27].
  • A multiple regression found the same three factors accounted for most of the explained variance in both the urban and the rural total PSE scores: these were the quality of social networks, difficulties with alcohol, and the past experience of childhood sexual abuse [28].
  • Problems in validating allegations of sexual abuse. Part 2: Clinical evaluation [29].

Analytical, diagnostic and therapeutic context of Sex Offenses

  • The 15-question survey addressed disclosure of abortion to the partner, reasons for nondisclosure if applicable, and physical and sexual abuse using a modified Abuse Assessment Screen. RESULTS: Of 960 patients, 85.2% completed the survey, for a final sample size of 818 [30].
  • Twelve women meeting prospective, DSM-IV criteria for PMDD, five of whom had a history of sexual abuse, participated in a randomized, placebo-controlled, double-blind, cross-over design study, comparing 2 months of on oral clonidine (0.3 mg/day) with 2 months on active placebo [19].
  • Centrifugation of approximately 50 mL of reddish colored formalin resulted in a cell pellet that was examined for DNA, which gave enough information to confirm a case of sexual abuse [31].
  • This is a retrospective study of 1,063 examinations performed on women at the Institute for Forensic Medicine in the city of Porto Alegre, RS, Brazil, between January 1998 and December 1999, as part of an investigation of charges of sexual abuse [32].


  1. Abuse, bullying, and discrimination as risk factors for binge eating disorder. Striegel-Moore, R.H., Dohm, F.A., Pike, K.M., Wilfley, D.E., Fairburn, C.G. The American journal of psychiatry. (2002) [Pubmed]
  2. Females experiencing sexual and drug vulnerabilities are at elevated risk for HIV infection among youth who use injection drugs. Miller, C.L., Spittal, P.M., LaLiberte, N., Li, K., Tyndall, M.W., O'Shaughnessy, M.V., Schechter, M.T. J. Acquir. Immune Defic. Syndr. (2002) [Pubmed]
  3. Medical and psychiatric symptoms in women with childhood sexual abuse. Walker, E.A., Katon, W.J., Hansom, J., Harrop-Griffiths, J., Holm, L., Jones, M.L., Hickok, L., Jemelka, R.P. Psychosomatic medicine. (1992) [Pubmed]
  4. Sex trading and psychological distress among women on methadone. El-Bassel, N., Simoni, J.M., Cooper, D.K., Gilbert, L., Schilling, R.F. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors. (2001) [Pubmed]
  5. Borderline personality disorder criteria associated with prospectively observed suicidal behavior. Yen, S., Shea, M.T., Sanislow, C.A., Grilo, C.M., Skodol, A.E., Gunderson, J.G., McGlashan, T.H., Zanarini, M.C., Morey, L.C. The American journal of psychiatry. (2004) [Pubmed]
  6. A comparative study of trauma and posttraumatic stress disorder prevalence in epilepsy patients and psychogenic nonepileptic seizure patients. Rosenberg, H.J., Rosenberg, S.D., Williamson, P.D., Wolford, G.L. Epilepsia (2000) [Pubmed]
  7. Corticotropin-releasing hormone (CRH) in psychiatry: from stress to psychopathology. Claes, S.J. Ann. Med. (2004) [Pubmed]
  8. Correlates of sexual abuse in women with anorexia nervosa and bulimia nervosa. deGroot, J.M., Kennedy, S., Rodin, G., McVey, G. Canadian journal of psychiatry. Revue canadienne de psychiatrie. (1992) [Pubmed]
  9. The experience of mistreatment and abuse among medical students. Baldwin, D.C., Daugherty, S.R., Eckenfels, E.J., Leksas, L. Proceedings of the ... Annual Conference on Research in Medical Education. Conference on Research in Medical Education. (1988) [Pubmed]
  10. Assessing for abuse during pregnancy. Severity and frequency of injuries and associated entry into prenatal care. McFarlane, J., Parker, B., Soeken, K., Bullock, L. JAMA (1992) [Pubmed]
  11. Physical and sexual abuse, salivary cortisol, and neurologic correlates of violent criminal behavior in female prison inmates. Brewer-Smyth, K., Burgess, A.W., Shults, J. Biol. Psychiatry (2004) [Pubmed]
  12. Treating acute posttraumatic reactions in children and adolescents. Cohen, J.A. Biol. Psychiatry (2003) [Pubmed]
  13. Serotonergic blunting to meta-chlorophenylpiperazine (m-CPP) highly correlates with sustained childhood abuse in impulsive and autoaggressive female borderline patients. Rinne, T., Westenberg, H.G., den Boer, J.A., van den Brink, W. Biol. Psychiatry (2000) [Pubmed]
  14. Nonepileptic seizures and childhood sexual and physical abuse. Alper, K., Devinsky, O., Perrine, K., Vazquez, B., Luciano, D. Neurology (1993) [Pubmed]
  15. Pouch dilatation following laparoscopic adjustable gastric banding: psychobehavioral factors (can psychiatrists predict pouch dilatation?). Poole, N., Al Atar, A., Bidlake, L., Fienness, A., McCluskey, S., Nussey, S., Bano, G., Morgan, J. Obesity surgery : the official journal of the American Society for Bariatric Surgery and of the Obesity Surgery Society of Australia and New Zealand. (2004) [Pubmed]
  16. Sexual harassment within dental offices in Washington State. Garvin, C., Sledge, S.H. Journal of dental hygiene : JDH / American Dental Hygienists' Association. (1992) [Pubmed]
  17. Gender-specific profiles of self-reported adolescent HIV risk behaviors. Krantz, S.R., Lynch, D.A., Russell, J.M. The Journal of the Association of Nurses in AIDS Care : JANAC. (2002) [Pubmed]
  18. Historical sexual abuse and current thyroid axis profiles in women with premenstrual dysphoric disorder. Girdler, S.S., Thompson, K.S., Light, K.C., Leserman, J., Pedersen, C.A., Prange, A.J. Psychosomatic medicine. (2004) [Pubmed]
  19. Histories of sexual abuse are associated with differential effects of clonidine on autonomic function in women with premenstrual dysphoric disorder. Bunevicius, R., Hinderliter, A.L., Light, K.C., Leserman, J., Pedersen, C.A., Girdler, S.S. Biological psychology. (2005) [Pubmed]
  20. Re-experienced sexual abuse as 'side effect' or cure following intravenous 2-chloroprocaine: comments on Phero et al., Pain, 43 (1990) 349-352. Marcus, N.J., Padawer, W.J. Pain (1991) [Pubmed]
  21. Growth hormone response patterns in sexually or physically abused boys. Jensen, J.B., Pease, J.J., ten Bensel, R., Garfinkel, B.D. Journal of the American Academy of Child and Adolescent Psychiatry. (1991) [Pubmed]
  22. Toluidine blue in the detection of perineal lacerations in pediatric and adolescent sexual abuse victims. McCauley, J., Gorman, R.L., Guzinski, G. Pediatrics (1986) [Pubmed]
  23. Sexual abuse, another hidden pediatric problem: the 1977 C. Anderson Aldrich lecture. Kempe, C.H. Pediatrics (1978) [Pubmed]
  24. Allegations of sexual abuse in an intensive care unit. Hansen-Flaschen, J., Adler, B.S. Crit. Care Med. (1999) [Pubmed]
  25. Retrospective reports of childhood trauma in adults with ADHD. Rucklidge, J.J., Brown, D.L., Crawford, S., Kaplan, B.J. Journal of attention disorders. (2006) [Pubmed]
  26. Childhood sexual abuse as a risk factor for depression in women: psychosocial and neurobiological correlates. Weiss, E.L., Longhurst, J.G., Mazure, C.M. The American journal of psychiatry. (1999) [Pubmed]
  27. The neurobiology of depression: inroads to treatment and new drug discovery. Nemeroff, C.B., Vale, W.W. The Journal of clinical psychiatry. (2005) [Pubmed]
  28. Psychiatric morbidity among women in urban and rural New Zealand: psycho-social correlates. Romans-Clarkson, S.E., Walton, V.A., Herbison, G.P., Mullen, P.E. The British journal of psychiatry : the journal of mental science. (1990) [Pubmed]
  29. Problems in validating allegations of sexual abuse. Part 2: Clinical evaluation. Benedek, E.P., Schetky, D.H. Journal of the American Academy of Child and Adolescent Psychiatry. (1987) [Pubmed]
  30. Abortion disclosure and the association with domestic violence. Woo, J., Fine, P., Goetzl, L. Obstetrics and gynecology. (2005) [Pubmed]
  31. Detection of fetal DNA in a cell pellet after centrifugation of mountant. Banaschak, S., Michael, M. J. Forensic Sci. (2003) [Pubmed]
  32. Women undergoing investigation of sexual abuse in the metropolitan area of Porto Alegre, Brazil: a retrospective study. Benfica, F.S., Vaz, M., Fróes, K. Medicine and law. (2002) [Pubmed]
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