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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Metrial Gland

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Disease relevance of Metrial Gland


High impact information on Metrial Gland


Biological context of Metrial Gland


Anatomical context of Metrial Gland


Associations of Metrial Gland with chemical compounds

  • The receptor changes in the myometrium were not as pronounced as in the endometrium especially with regard to the low myometrial levels of nuclear E2 and P. The metrial gland which comes into prominence while the deciduoma is regressing, showed sustained high concentrations of cytosolic P receptor [10].
  • A study has been made of the differentiation of granulated metrial gland (GMG) cells in ovariectomized mice given progesterone and oestradiol at a time equivalent to the first 6 days of pregnancy [13].
  • During the first 2 days of culture IgG was detected in glycoprotein granule-containing granulated metrial gland (GMG) cells [14].
  • The asialo-GM1 antigen was found on rat GMG cells in culture and in cryostat sections of rat metrial gland [15].
  • The possibility that purine-degrading and oxyradical-forming enzymes support decidual as well as metrial gland regression, and thus placental separation, by direct tissue damage and/or by indirect rupture of lysosomal membranes, inducing the release of acid hydrolases, is considered [16].

Gene context of Metrial Gland

  • IGFBP-2, -5 and -6 mRNAs were detected in the stroma of the metrial gland [17].
  • METHOD: uNK cells migrating from explant cultures of the metrial gland were assessed for expression (mRNA and protein) of each chain of the IL-2 receptor (IL-2R) [18].
  • In this study, inducible and endothelial NOS isoforms were immunolocalized to rat granulated metrial gland (GMG) cells using anti-NOS antibodies proven to be isoform specific [19].
  • The number of metrial gland cells as well as the number of uterine leucocytes expressing CSF-1 and c-fms mRNAs was substantially lower in the uteroplacental unit of mice with pregnancy loss than in control animals [20].
  • On days 13 and 14, expression for IGF-I mRNA could be detected in the mesometrial decidua and metrial gland but no expression was observed for IGF-II mRNA [21].

Analytical, diagnostic and therapeutic context of Metrial Gland


  1. Effect of serum on mouse granulated metrial gland cell cytotoxicity. Stewart, I.J., Peel, S. Am. J. Reprod. Immunol. (1999) [Pubmed]
  2. Engraftment of bone marrow from severe combined immunodeficient (SCID) mice reverses the reproductive deficits in natural killer cell-deficient tg epsilon 26 mice. Guimond, M.J., Wang, B., Croy, B.A. J. Exp. Med. (1998) [Pubmed]
  3. Perforin-expressing granulated metrial gland cells in murine deciduoma. Zheng, L.M., Joag, S.V., Parr, M.B., Parr, E.L., Young, J.D. J. Exp. Med. (1991) [Pubmed]
  4. Immunogold labeling of perforin and serine esterases in granulated metrial gland cells. Zheng, L.M., Ojcius, D.M., Liu, C.C., Kramer, M.D., Simon, M.M., Parr, E.L., Young, J.D. FASEB J. (1991) [Pubmed]
  5. Granzymes D, E, F, and G are regulated through pregnancy and by IL-2 and IL-15 in granulated metrial gland cells. Allen, M.P., Nilsen-Hamilton, M. J. Immunol. (1998) [Pubmed]
  6. Murine granulated metrial gland cells at uterine implantation sites are natural killer lineage cells. Linnemeyer, P.A., Pollack, S.B. J. Immunol. (1991) [Pubmed]
  7. Hormonal dependence of the metrial gland: further studies on oestradiol and progesterone receptor levels in the rat. Martel, D., Monier, M.N., Roche, D., De Feo, V.J., Psychoyos, A. J. Endocrinol. (1989) [Pubmed]
  8. A study of granulated metrial gland cells in the pregnant, alymphoplasia (aly/aly) mice. Kiso, Y., Kusakabe, K., Tokunaga, Y., Makita, M., Okada, T., Sasaki, F. J. Vet. Med. Sci. (1997) [Pubmed]
  9. Tumor necrosis factor-alpha mRNA and protein in rat uterine and placental cells. Yelavarthi, K.K., Chen, H.L., Yang, Y.P., Cowley, B.D., Fishback, J.L., Hunt, J.S. J. Immunol. (1991) [Pubmed]
  10. Estrogen and progesterone receptors in the endometrium, myometrium, and metrial gland of the rat during the decidualization process. Martel, D., Monier, M.N., Psychoyos, A., DeFeo, V.J. Endocrinology (1984) [Pubmed]
  11. Accounting for the peripartum loss of granulated metrial gland cells, a natural killer cell population, from the pregnant mouse uterus. Delgado, S.R., McBey, B.A., Yamashiro, S., Fujita, J., Kiso, Y., Croy, B.A. J. Leukoc. Biol. (1996) [Pubmed]
  12. Evidence of specialized leukocyte-vascular homing interactions at the maternal/fetal interface. Kruse, A., Merchant, M.J., Hallmann, R., Butcher, E.C. Eur. J. Immunol. (1999) [Pubmed]
  13. Differentiation of granulated metrial gland cells in ovariectomized mice given ovarian hormones. Stewart, I. J. Endocrinol. (1987) [Pubmed]
  14. Uptake of immunoglobulin and albumin by granulated metrial gland cells in vitro. Mitchell, B.S., Peel, S. J. Reprod. Fertil. (1987) [Pubmed]
  15. The killing of rat placental cells by rat and mouse granulated metrial gland cells in vitro. Peel, S., Adam, E. Placenta (1991) [Pubmed]
  16. Comparative enzyme histochemistry of the early and term rat decidua with special attention to decidual regression. Straatsburg, I.H., Gossrau, R. Histochem. J. (1994) [Pubmed]
  17. The expression of insulin-like growth factor and insulin-like growth factor binding protein mRNAs in mouse placenta. Carter, A.M., Nygard, K., Mazzuca, D.M., Han, V.K. Placenta (2006) [Pubmed]
  18. Uterine natural killer cells do not require interleukin-2 for their differentiation or maturation. Croy, B.A., Guimond, M.J., Luross, J., Hahnel, A., Wang, B., van den Heuvel, M. Am. J. Reprod. Immunol. (1997) [Pubmed]
  19. Granulated metrial gland cells contain nitric oxide synthases during pregnancy in the rat. Sladek, S.M., Kanbour-Shakir, A., Watkins, S., Berghorn, K.A., Hoffman, G.E., Roberts, J.M. Placenta (1998) [Pubmed]
  20. Colony-stimulating factor-1 (CSF-1) expression in the uteroplacental unit of mice with spontaneous and induced pregnancy loss. Gorivodsky, M., Torchinsky, A., Shepshelovich, J., Savion, S., Fein, A., Carp, H., Toder, V. Clin. Exp. Immunol. (1999) [Pubmed]
  21. Expression of mRNA encoding insulin-like growth factors I and II by uterine tissues and placenta during pregnancy in the rat. Correia-da-Silva, G., Bell, S.C., Pringle, J.H., Teixeira, N. Mol. Reprod. Dev. (1999) [Pubmed]
  22. Effects of exogenous progesterone following ovariectomy on the metrial glands of pregnant mice. Sharma, R., Bulmer, D., Peel, S. J. Anat. (1986) [Pubmed]
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