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Gene Review

Vcam1  -  vascular cell adhesion molecule 1

Mus musculus

Synonyms: CD106, V-CAM 1, VCAM-1, Vascular cell adhesion protein 1, Vcam-1
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Disease relevance of Vcam1


High impact information on Vcam1


Chemical compound and disease context of Vcam1


Biological context of Vcam1


Anatomical context of Vcam1


Associations of Vcam1 with chemical compounds


Physical interactions of Vcam1


Regulatory relationships of Vcam1


Other interactions of Vcam1


Analytical, diagnostic and therapeutic context of Vcam1


  1. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. Johnson, L.A., Clasper, S., Holt, A.P., Lalor, P.F., Baban, D., Jackson, D.G. J. Exp. Med. (2006) [Pubmed]
  2. Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. Koni, P.A., Joshi, S.K., Temann, U.A., Olson, D., Burkly, L., Flavell, R.A. J. Exp. Med. (2001) [Pubmed]
  3. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. Cybulsky, M.I., Iiyama, K., Li, H., Zhu, S., Chen, M., Iiyama, M., Davis, V., Gutierrez-Ramos, J.C., Connelly, P.W., Milstone, D.S. J. Clin. Invest. (2001) [Pubmed]
  4. Essential roles of tumor necrosis factor receptor p55 in liver metastasis of intrasplenic administration of colon 26 cells. Kitakata, H., Nemoto-Sasaki, Y., Takahashi, Y., Kondo, T., Mai, M., Mukaida, N. Cancer Res. (2002) [Pubmed]
  5. Effect of tumor necrosis factor alpha and intercellular adhesion molecule-1 expression on immunogenicity of murine liver cells in mice. Bumgardner, G.L., Li, J., Apte, S., Heininger, M., Frankel, W.L. Hepatology (1998) [Pubmed]
  6. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Berlin, C., Berg, E.L., Briskin, M.J., Andrew, D.P., Kilshaw, P.J., Holzmann, B., Weissman, I.L., Hamann, A., Butcher, E.C. Cell (1993) [Pubmed]
  7. Roles for the integrin VLA-4 and its counter receptor VCAM-1 in myogenesis. Rosen, G.D., Sanes, J.R., LaChance, R., Cunningham, J.M., Roman, J., Dean, D.C. Cell (1992) [Pubmed]
  8. Lipoic acid inhibits expression of ICAM-1 and VCAM-1 by CNS endothelial cells and T cell migration into the spinal cord in experimental autoimmune encephalomyelitis. Chaudhary, P., Marracci, G.H., Bourdette, D.N. J. Neuroimmunol. (2006) [Pubmed]
  9. Molecular pathways of monocyte emigration into the alveolar air space of intact mice. Maus, U., Huwe, J., Ermert, L., Ermert, M., Seeger, W., Lohmeyer, J. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  10. Endothelial expression of vascular cell adhesion molecule-1 correlates with metastatic pattern in spontaneous melanoma. Langley, R.R., Carlisle, R., Ma, L., Specian, R.D., Gerritsen, M.E., Granger, D.N. Microcirculation (New York, N.Y. : 1994) (2001) [Pubmed]
  11. Fourteen-membered ring macrolides inhibit vascular cell adhesion molecule 1 messenger RNA induction and leukocyte migration: role in preventing lung injury and fibrosis in bleomycin-challenged mice. Li, Y., Azuma, A., Takahashi, S., Usuki, J., Matsuda, K., Aoyama, A., Kudoh, S. Chest (2002) [Pubmed]
  12. A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture. Miyake, K., Medina, K., Ishihara, K., Kimoto, M., Auerbach, R., Kincade, P.W. J. Cell Biol. (1991) [Pubmed]
  13. Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage. Dansky, H.M., Barlow, C.B., Lominska, C., Sikes, J.L., Kao, C., Weinsaft, J., Cybulsky, M.I., Smith, J.D. Arterioscler. Thromb. Vasc. Biol. (2001) [Pubmed]
  14. Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis. Honda, K., Nakano, H., Yoshida, H., Nishikawa, S., Rennert, P., Ikuta, K., Tamechika, M., Yamaguchi, K., Fukumoto, T., Chiba, T., Nishikawa, S.I. J. Exp. Med. (2001) [Pubmed]
  15. LFA-1 is required for retention of effector CD8 T cells in mouse lungs. Thatte, J., Dabak, V., Williams, M.B., Braciale, T.J., Ley, K. Blood (2003) [Pubmed]
  16. Up-regulation of endothelial nitric oxide synthase inhibits pulmonary leukocyte migration following lung ischemia-reperfusion in mice. Kaminski, A., Pohl, C.B., Sponholz, C., Ma, N., Stamm, C., Vollmar, B., Steinhoff, G. Am. J. Pathol. (2004) [Pubmed]
  17. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Huo, Y., Schober, A., Forlow, S.B., Smith, D.F., Hyman, M.C., Jung, S., Littman, D.R., Weber, C., Ley, K. Nat. Med. (2003) [Pubmed]
  18. Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice. Lei, X.F., Ohkawara, Y., Stämpfli, M.R., Mastruzzo, C., Marr, R.A., Snider, D., Xing, Z., Jordana, M. J. Clin. Invest. (1998) [Pubmed]
  19. Direct demonstration of P-selectin- and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E-deficient mice. Ramos, C.L., Huo, Y., Jung, U., Ghosh, S., Manka, D.R., Sarembock, I.J., Ley, K. Circ. Res. (1999) [Pubmed]
  20. Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Yang, J.T., Rayburn, H., Hynes, R.O. Development (1995) [Pubmed]
  21. Oncostatin-M up-regulates VCAM-1 and synergizes with IL-4 in eotaxin expression: involvement of STAT6. Fritz, D.K., Kerr, C., Tong, L., Smyth, D., Richards, C.D. J. Immunol. (2006) [Pubmed]
  22. Differential reactivity of brain microvascular endothelial cells to TNF reflects the genetic susceptibility to cerebral malaria. Lou, J., Gasche, Y., Zheng, L., Critico, B., Monso-Hinard, C., Juillard, P., Morel, P., Buurman, W.A., Grau, G.E. Eur. J. Immunol. (1998) [Pubmed]
  23. AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent. Sundell, C.L., Somers, P.K., Meng, C.Q., Hoong, L.K., Suen, K.L., Hill, R.R., Landers, L.K., Chapman, A., Butteiger, D., Jones, M., Edwards, D., Daugherty, A., Wasserman, M.A., Alexander, R.W., Medford, R.M., Saxena, U. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  24. Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. Baron, J.L., Madri, J.A., Ruddle, N.H., Hashim, G., Janeway, C.A. J. Exp. Med. (1993) [Pubmed]
  25. VLA-4 is involved in the engraftment of the human pre-B acute lymphoblastic leukaemia cell line NALM-6 in SCID mice. Filshie, R., Gottlieb, D., Bradstock, K. Br. J. Haematol. (1998) [Pubmed]
  26. Dysregulated expression of cellular adhesion molecules in autoimmune-prone mice. Wang, W., Kobayashi, S., Uede, T. J. Dermatol. (1992) [Pubmed]
  27. N-acetyl cysteine blocks mesangial VCAM-1 and NF-kappa B expression in vivo. Khachigian, L.M., Collins, T., Fries, J.W. Am. J. Pathol. (1997) [Pubmed]
  28. Involvement of very late activation antigen 4 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) in tumor necrosis factor alpha enhancement of experimental metastasis. Okahara, H., Yagita, H., Miyake, K., Okumura, K. Cancer Res. (1994) [Pubmed]
  29. The VCAM-1 gene that encodes the vascular cell adhesion molecule is a target of the Sry-related high mobility group box gene, Sox18. Hosking, B.M., Wang, S.C., Downes, M., Koopman, P., Muscat, G.E. J. Biol. Chem. (2004) [Pubmed]
  30. Role of inducible nitric oxide synthase in the regulation of VCAM-1 expression in gut inflammation. Kawachi, S., Cockrell, A., Laroux, F.S., Gray, L., Granger, D.N., van der Heyde, H.C., Grisham, M.B. Am. J. Physiol. (1999) [Pubmed]
  31. Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2. Abonia, J.P., Austen, K.F., Rollins, B.J., Joshi, S.K., Flavell, R.A., Kuziel, W.A., Koni, P.A., Gurish, M.F. Blood (2005) [Pubmed]
  32. Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse. Henninger, D.D., Panés, J., Eppihimer, M., Russell, J., Gerritsen, M., Anderson, D.C., Granger, D.N. J. Immunol. (1997) [Pubmed]
  33. TNF-alpha contributes to the development of allergic rhinitis in mice. Iwasaki, M., Saito, K., Takemura, M., Sekikawa, K., Fujii, H., Yamada, Y., Wada, H., Mizuta, K., Seishima, M., Ito, Y. J. Allergy Clin. Immunol. (2003) [Pubmed]
  34. Vascular cell adhesion molecule-Ig fusion protein selectively targets activated alpha 4-integrin receptors in vivo. Inhibition of autoimmune diabetes in an adoptive transfer model in nonobese diabetic mice. Jakubowski, A., Ehrenfels, B.N., Pepinsky, R.B., Burkly, L.C. J. Immunol. (1995) [Pubmed]
  35. Differential response of vascular smooth muscle cells to oxidized LDL in mouse strains with different atherosclerosis susceptibility. Miyoshi, T., Tian, J., Matsumoto, A.H., Shi, W. Atherosclerosis (2006) [Pubmed]
  36. The atheroprotective effect of 17 beta-estradiol is not altered in P-selectin- or ICAM-1-deficient hypercholesterolemic mice. Gourdy, P., Mallat, Z., Castano, C., Garmy-Susini, B., Mac Gregor, J.L., Tedgui, A., Arnal, J.F., Bayard, F. Atherosclerosis (2003) [Pubmed]
  37. Expression of functional ICAM-1 and VCAM-1 adhesion molecules by an immortalized epithelial cell clone derived from the small intestine. Li, X.C., Jevnikar, A.M., Grant, D.R. Cell. Immunol. (1997) [Pubmed]
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