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Gene Review

oed  -  edematous

Mus musculus

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Disease relevance of oed


Psychiatry related information on oed

  • On gross inspection, 70% of lungs of combined therapy group showed signs of congestion, 10% edematous changes and 20% blackish mottling [6].

High impact information on oed


Chemical compound and disease context of oed


Biological context of oed

  • Although hemorrhagic necrosis and edematous changes could be explained by quantitative differences in skin lesions, the other possible explanation is that hemorrhagic necrosis and the increase in local vascular permeability are induced by different mechanisms, only one of which depends on the regulation of the lps gene [17].
  • At E17.5, Ts16 fetuses exhibited two distinct phenotypes, one with an edematous morphology and the other runt-like [18].
  • This suggests that excitotoxins cause lipid peroxidation possibly by acting at intracellular loci which become more accessible following disruption of cells in vitro and by extrapolation, possibly in vivo due to cellular permeability changes during the edematous stage of ischemic and other related neuropathological conditions [19].
  • RESULTS: Following dissection, an imbalance in homeostasis began with positive BCL2 and TPR53BP2 expression in the edematous ciliary processes, and resulted in atrophy of the NPE [20].
  • The cell count and mean fluorescence intensity indicated upregulated expression of CD32/CD16 on peritoneal exudative neutrophils in edematous pancreatitis, whereas the upregulation was attenuated in necrotizing pancreatitis [21].

Anatomical context of oed


Associations of oed with chemical compounds

  • Edematous necrosis in thiamine-deficient encephalopathy of the mouse [24].
  • Synthesis of the arachidonic acid metabolites precedes or is coincident with increased vascular permeability resulting in an edematous response, as measured by accumulation of [125I]albumin in the ear after i.v. injection or by tissue wet weight [26].
  • Orally administered 0.4% lutein and zeaxanthin decreased significantly the edematous cutaneous response (p<0.01) as determined by the reduction of the UVB-induced increase of ear bifold thickening [27].
  • This study examined the early response of pro-inflammatory and regulatory cytokines in the mouse brain following triethyltin (TET)-induced myelin injury characterized by edematous vacuolation [28].
  • These edematous and biochemical changes were prevented by the treatment with 0.01-0.03 mg/kg s.c. of OP-2507 [29].

Other interactions of oed

  • IL-1ra was administered in escalating doses either before or after acute edematous, necrotizing pancreatitis was induced in adult male mice by injection of cerulein [30].
  • From these data we conclude that the edematous response and proliferation of lumenal epithelial cells in the murine uterus are mediated in part through VEGF-A [31].
  • Taken together, these data illustrate the potent antiinflammatory effects of SK&F 86002 and support the suggestion that 5-lipoxygenase products play a significant role in both the edematous and cellular phases of arachidonic acid-induced inflammation [32].
  • These morphological observations reveal that, in newborn mice, the ependymal cells are the most sensitive to the toxic action of 6-AN and suggest that the pathogenesis of 6-AN-induced hydrocephalus is likely to be due to the combination of ependymal cell damage and compression of the lumen by the edematous periaqueductal gray matter [33].
  • The recovered myeloperoxidase activity in edematous paw was significantly decreased in mice pretreated with magnolol and BW755C [34].

Analytical, diagnostic and therapeutic context of oed


  1. Lipid deficiencies, leukocytosis, brittle skin--a lethal syndrome caused by a recessive mutation, edematous (oed), in the mouse. Schiffman, M.B., Santorineou, M.L., Lewis, S.E., Turchin, H.A., Gluecksohn-Waelsch, S. Genetics (1975) [Pubmed]
  2. Intracellular vacuoles in experimental acute pancreatitis in rats and mice are an acidified compartment. Niederau, C., Grendell, J.H. J. Clin. Invest. (1988) [Pubmed]
  3. Induction by cholera toxin of synchronous divisions in vivo in the epidermis resulting in hyperplasia. Kuroki, T. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  4. Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice. Yagi, H., Deguchi, K., Aono, A., Tani, Y., Kishimoto, T., Komori, T. Blood (1998) [Pubmed]
  5. Early-type hypersensitivity-associated airway inflammation and eosinophilia induced by Dermatophagoides farinae in sensitized mice. Yu, C.K., Lee, S.C., Wang, J.Y., Hsiue, T.R., Lei, H.Y. J. Immunol. (1996) [Pubmed]
  6. Effects of methotrexate and total body irradiation on mouse lungs. Alam, M.I., Jafarey, N.A. JPMA. The Journal of the Pakistan Medical Association. (1990) [Pubmed]
  7. Engraftment of bone marrow from severe combined immunodeficient (SCID) mice reverses the reproductive deficits in natural killer cell-deficient tg epsilon 26 mice. Guimond, M.J., Wang, B., Croy, B.A. J. Exp. Med. (1998) [Pubmed]
  8. Interleukin 4 and T helper type 2 cells are required for development of experimental onchocercal keratitis (river blindness). Pearlman, E., Lass, J.H., Bardenstein, D.S., Kopf, M., Hazlett, F.E., Diaconu, E., Kazura, J.W. J. Exp. Med. (1995) [Pubmed]
  9. Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Swamynathan, S.K., Katz, J.P., Kaestner, K.H., Ashery-Padan, R., Crawford, M.A., Piatigorsky, J. Mol. Cell. Biol. (2007) [Pubmed]
  10. Can oligodendrocytes attached to myelin proliferate? Ludwin, S.K., Bakker, D.A. J. Neurosci. (1988) [Pubmed]
  11. Prevention of doxorubicin myocardial toxicity in mice by reduced glutathione. Yoda, Y., Nakazawa, M., Abe, T., Kawakami, Z. Cancer Res. (1986) [Pubmed]
  12. Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis. Sakai, Y., Masamune, A., Satoh, A., Nishihira, J., Yamagiwa, T., Shimosegawa, T. Gastroenterology (2003) [Pubmed]
  13. Sunscreen protection against ultraviolet radiation-induced pyrimidine dimers in mouse epidermal DNA. Ley, R.D., Fourtanier, A. Photochem. Photobiol. (1997) [Pubmed]
  14. Effects of cyclosporine and tacrolimus (FK 506) on acute pancreatitis in mice. Echigo, Y., Inoue, K., Kogire, M., Doi, R., Higashide, S., Sumi, S., Kaji, H., Imamura, M. Archives of surgery (Chicago, Ill. : 1960) (1995) [Pubmed]
  15. Therapeutic effects of loxiglumide on experimental acute pancreatitis using various models. Satake, K., Kimura, K., Saito, T. Digestion (1999) [Pubmed]
  16. Effects of the seleno-organic substance Ebselen in two different models of acute pancreatitis. Niederau, C., Ude, K., Niederau, M., Lüthen, R., Strohmeyer, G., Ferrell, L.D., Grendell, J.H. Pancreas (1991) [Pubmed]
  17. Local skin response in mice induced by a single intradermal injection of bacterial lipopolysaccharide and lipid A. Ishikawa, Y., Kirikae, T., Hirata, M., Yoshida, M., Haishima, Y., Kondo, S., Hisatsune, K. Infect. Immun. (1991) [Pubmed]
  18. Effects of genetic background on cardiovascular anomalies in the Ts16 mouse. Villar, A.J., Kim, J., De Blank, P., Gillespie, A.M., Kozy, H.M., Ursell, P.C., Epstein, C.J. Dev. Dyn. (2005) [Pubmed]
  19. Effects of excitotoxins on free radical indices in mouse brain. Bose, R., Schnell, C.L., Pinsky, C., Zitko, V. Toxicol. Lett. (1992) [Pubmed]
  20. Effects of gamma irradiation on BCL2 and TPR53BP2 expression in the porcine ciliary body. Akeo, K., Funayama, T., Ogawa, A., Hamada, N., Akeo, Y., Kobayashi, Y. Exp. Anim. (2006) [Pubmed]
  21. Acute necrotizing pancreatitis reduces opsonin receptor expression on peritoneal exudative neutrophils in mice. Sugiyama, M., Hatano, N., Watanabe, T., Atomi, Y. Hepatogastroenterology (2005) [Pubmed]
  22. Lesions in the skin, intestine, and central nervous system induced by an antimetabolite of niacin. Aikawa, H., Suzuki, K. Am. J. Pathol. (1986) [Pubmed]
  23. Early edematous lesion of pyrithiamine induced acute thiamine deficient encephalopathy in the mouse. Watanabe, I., Kanabe, S. J. Neuropathol. Exp. Neurol. (1978) [Pubmed]
  24. Edematous necrosis in thiamine-deficient encephalopathy of the mouse. Watanabe, I., Tomita, T., Hung, K.S., Iwasaki, Y. J. Neuropathol. Exp. Neurol. (1981) [Pubmed]
  25. Macrophage apolipoprotein synthesis and endoneurial distribution as a response to segmental demyelination. Gelman, B.B., Goodrum, J., Bouldin, T.W. J. Neuropathol. Exp. Neurol. (1991) [Pubmed]
  26. Prostaglandin and leukotriene synthesis in mouse ears inflamed by arachidonic acid. Opas, E.E., Bonney, R.J., Humes, J.L. J. Invest. Dermatol. (1985) [Pubmed]
  27. Dietary lutein/zeaxanthin decreases ultraviolet B-induced epidermal hyperproliferation and acute inflammation in hairless mice. González, S., Astner, S., An, W., Goukassian, D., Pathak, M.A. J. Invest. Dermatol. (2003) [Pubmed]
  28. Increase in brain stem cytokine mRNA levels as an early response to chemical-induced myelin edema. Mehta, P.S., Bruccoleri, A., Brown, H.W., Harry, G.J. J. Neuroimmunol. (1998) [Pubmed]
  29. Protective effect of a new prostacyclin analogue OP-2507 against cerebral anoxia and edema in experimental animals. Masuda, Y., Ochi, Y., Ochi, Y., Karasawa, T., Hatano, N., Kadokawa, T., Okegawa, T. Eur. J. Pharmacol. (1986) [Pubmed]
  30. Interleukin-1 receptor antagonist decreases severity of experimental acute pancreatitis. Norman, J., Franz, M., Messina, J., Riker, A., Fabri, P.J., Rosemurgy, A.S., Gower, W.R. Surgery (1995) [Pubmed]
  31. Soluble vascular endothelial growth factor receptor 1 inhibits edema and epithelial proliferation induced by 17beta-estradiol in the mouse uterus. Hastings, J.M., Licence, D.R., Burton, G.J., Charnock-Jones, D.S., Smith, S.K. Endocrinology (2003) [Pubmed]
  32. Arachidonic acid-induced inflammation: inhibition by dual inhibitor of arachidonic acid metabolism, SK&F 86002. Griswold, D.E., Webb, E., Schwartz, L., Hanna, N. Inflammation (1987) [Pubmed]
  33. 6-Aminonicotinamide-induced hydrocephalus in suckling mice. Aikawa, H., Suzuki, K., Ito, N., Iwasaki, Y., Nonaka, I. J. Neuropathol. Exp. Neurol. (1984) [Pubmed]
  34. Anti-inflammatory and analgesic effects of magnolol. Wang, J.P., Hsu, M.F., Raung, S.L., Chen, C.C., Kuo, J.S., Teng, C.M. Naunyn Schmiedebergs Arch. Pharmacol. (1992) [Pubmed]
  35. Purification and characterization of Clostridium sordellii lethal toxin and cross-reactivity with Clostridium difficile cytotoxin. Popoff, M.R. Infect. Immun. (1987) [Pubmed]
  36. Acute cholecystitis and persistent liver necrosis in mice provoked by isothiocyanate. Ungar, H., Popp, J.A. Arch. Pathol. Lab. Med. (1976) [Pubmed]
  37. A murine photochemical stroke model with histologic correlates of apoptotic and nonapoptotic mechanisms. Eichenbaum, J.W., Pevsner, P.H., Pivawer, G., Kleinman, G.M., Chiriboga, L., Stern, A., Rosenbach, A., Iannuzzi, K., Miller, D.C. Journal of pharmacological and toxicological methods. (2002) [Pubmed]
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