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MeSH Review

Focal Nodular Hyperplasia

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Disease relevance of Focal Nodular Hyperplasia


High impact information on Focal Nodular Hyperplasia

  • Both contraceptive steroids and pregnancy, with high levels of endogenous sex steroids, favored tumor growth in this patient, suggesting that focal nodular hyperplasia can be steroid related [6].
  • We have analyzed the composition of the tumor stroma and the expression of cell-matrix and cell-cell adhesion molecules in 11 cases of fibrolamellar carcinoma of the liver (FLC), in comparison with 34 cases of hepatocellular carcinoma and 8 cases of focal nodular hyperplasia [7].
  • Studies to date do not provide consistent and convincing evidence that any form of exogenous estrogen alters the risk of cancers of the breast or ovary or that oral contraceptives alter the risk of cervical neoplasia or focal nodular hyperplasia of the liver, although recent reports suggest that continued vigilance is warranted [8].
  • No APC mutations were seen in focal nodular hyperplasia of the liver, angiofibrolipoma, and seborrheic wart [9].
  • Hypervascular liver lesions: differentiation of focal nodular hyperplasia from malignant tumors with dynamic gadolinium-enhanced MR imaging [10].

Chemical compound and disease context of Focal Nodular Hyperplasia


Biological context of Focal Nodular Hyperplasia


Anatomical context of Focal Nodular Hyperplasia


Gene context of Focal Nodular Hyperplasia


Analytical, diagnostic and therapeutic context of Focal Nodular Hyperplasia


  1. Androgen receptor in human liver: characterization and quantitation in normal and diseased liver. Eagon, P.K., Elm, M.S., Stafford, E.A., Porter, L.E. Hepatology (1994) [Pubmed]
  2. Liver hepatocyte growth factor does not always correlate with hepatocellular proliferation in human liver lesions: its specific receptor c-met does. D'Errico, A., Fiorentino, M., Ponzetto, A., Daikuhara, Y., Tsubouchi, H., Brechot, C., Scoazec, J.Y., Grigioni, W.F. Hepatology (1996) [Pubmed]
  3. Liver mass evaluation with ultrasound: the impact of microbubble contrast agents and pulse inversion imaging. Wilson, S.R., Burns, P.N. Semin. Liver Dis. (2001) [Pubmed]
  4. Enhanced glypican-3 expression differentiates the majority of hepatocellular carcinomas from benign hepatic disorders. Zhu, Z.W., Friess, H., Wang, L., Abou-Shady, M., Zimmermann, A., Lander, A.D., Korc, M., Kleeff, J., Büchler, M.W. Gut (2001) [Pubmed]
  5. Expression of Ep-CAM in normal, regenerating, metaplastic, and neoplastic liver. de Boer, C.J., van Krieken, J.H., Janssen-van Rhijn, C.M., Litvinov, S.V. J. Pathol. (1999) [Pubmed]
  6. Oral contraceptives, pregnancy, and focal nodular hyperplasia of the liver. Scott, L.D., Katz, A.R., Duke, J.H., Cowan, D.F., Maklad, N.F. JAMA (1984) [Pubmed]
  7. Fibrolamellar carcinoma of the liver: composition of the extracellular matrix and expression of cell-matrix and cell-cell adhesion molecules. Scoazec, J.Y., Flejou, J.F., D'Errico, A., Fiorentino, M., Zamparelli, A., Bringuier, A.F., Feldmann, G., Grigioni, W.F. Hepatology (1996) [Pubmed]
  8. Role of exogenous female hormones in altering the risk of benign and malignant neoplasms in humans. Thomas, D.B. Cancer Res. (1978) [Pubmed]
  9. Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli. Bläker, H., Sutter, C., Kadmon, M., Otto, H.F., Von Knebel-Doeberitz, M., Gebert, J., Helmke, B.M. Genes Chromosomes Cancer (2004) [Pubmed]
  10. Hypervascular liver lesions: differentiation of focal nodular hyperplasia from malignant tumors with dynamic gadolinium-enhanced MR imaging. Mahfouz, A.E., Hamm, B., Taupitz, M., Wolf, K.J. Radiology. (1993) [Pubmed]
  11. Technetium-99m DISIDA hepatobiliary agent in diagnosis of hepatocellular carcinoma, adenoma, and focal nodular hyperplasia. Kotzerke, J., Schwarzrock, R., Krischek, O., Wiese, H., Hundeshagen, H. J. Nucl. Med. (1989) [Pubmed]
  12. Focal nodular hyperplasia associated with the use of a synthetic anabolic androgen. Alberti-Flor, J.J., Iskandarani, M., Jeffers, L., Zeppa, R., Schiff, E.R. Am. J. Gastroenterol. (1984) [Pubmed]
  13. Angiotensin I-converting enzyme (CD143) is down-regulated in focal nodular hyperplasia of the liver. Gräntzdörffer, I., Lendeckel, U., Carl-McGrath, S., Roessner, A., Röcken, C. Am. J. Surg. Pathol. (2004) [Pubmed]
  14. Focal nodular hyperplasia of the liver: composition of the extracellular matrix and expression of cell-cell and cell-matrix adhesion molecules. Scoazec, J.Y., Flejou, J.F., D'Errico, A., Couvelard, A., Kozyraki, R., Fiorentino, M., Grigioni, W.F., Feldmann, G. Hum. Pathol. (1995) [Pubmed]
  15. Assessment of sequential enhancement patterns of focal nodular hyperplasia and hepatocellular carcinoma on mangafodipir trisodium enhanced MR imaging. Savellano, D.H., Köstler, H., Baus, S., Mössinger, M., Gratz, K.F., Weimann, A., Galanski, M. Investigative radiology. (2004) [Pubmed]
  16. 11C-acetate PET imaging in hepatocellular carcinoma and other liver masses. Ho, C.L., Yu, S.C., Yeung, D.W. J. Nucl. Med. (2003) [Pubmed]
  17. Comparative genomic hybridization. Synchronous occurrence of focal nodular hyperplasia and hepatocellular carcinoma in the same liver is not based on common chromosomal aberrations. Kellner, U., Jacobsen, A., Kellner, A., Mantke, R., Roessner, A., Röcken, C. Am. J. Clin. Pathol. (2003) [Pubmed]
  18. Endothelial cell differentiation in hepatocellular adenomas: implications for histopathological diagnosis. Gouysse, G., Frachon, S., Hervieu, V., Fiorentino, M., d'Errico, A., Dumortier, J., Boillot, O., Partensky, C., Grigioni, W.F., Scoazec, J.Y. J. Hepatol. (2004) [Pubmed]
  19. Different gene expression of MDM2, GAGE-1, -2 and FHIT in hepatocellular carcinoma and focal nodular hyperplasia. Schlott, T., Ahrens, K., Ruschenburg, I., Reimer, S., Hartmann, H., Droese, M. Br. J. Cancer (1999) [Pubmed]
  20. Hepatic estrogen and progesterone receptors in an estrogen-associated hepatic neoplasm. Macdonald, J.S., Lippman, M.E., Woolley, P.V., Petrucci, P.P., Schein, P.S. Cancer Chemother. Pharmacol. (1978) [Pubmed]
  21. A serotonin and beta HCG-producing islet cell carcinoma associated with focal nodular hyperplasia of the liver. Prinz, R.A., Bermes, E.W., Chejfec, G., Fareed, J., Klich, J. Journal of surgical oncology. (1983) [Pubmed]
  22. Clinical significance of 99mTc-N-pyridoxyl-5-methyltryptophan (99mTc-PMT) in the diagnosis of intrahepatic masses. Oyamada, H., Yamazaki, S., Makuuchi, M., Hasegawa, H. Radioisotopes (1989) [Pubmed]
  23. High expression of the proliferation and apoptosis associated CSE1L/CAS gene in hepatitis and liver neoplasms: correlation with tumor progression. Wellmann, A., Flemming, P., Behrens, P., Wuppermann, K., Lang, H., Oldhafer, K., Pastan, I., Brinkmann, U. Int. J. Mol. Med. (2001) [Pubmed]
  24. CYP1A1 alleles in women with focal nodular hyperplasia of the liver (FNH). Lazar, A., Menzel, H., Cascorbi, I., Kümel, G., Sachs, M., Rietbrock, S., Roots, I., Fuhr, U. International journal of clinical pharmacology and therapeutics. (2004) [Pubmed]
  25. Expression of cell adhesion molecule CD44 in primary tumors of the liver: an immunohistochemical study. Washington, K., Telen, M.J., Gottfried, M.R. Liver (1997) [Pubmed]
  26. Utility of CD34 reactivity in evaluating focal nodular hepatocellular lesions sampled by fine needle aspiration biopsy. Kong, C.S., Appenzeller, M., Ferrell, L.D. Acta Cytol. (2000) [Pubmed]
  27. Scintigraphic triad in focal nodular hyperplasia. Tanasescu, D., Brachman, M., Rigby, J., Yadegar, J., Ramanna, L., Waxman, A. Am. J. Gastroenterol. (1984) [Pubmed]
  28. Fibrolamellar hepatocellular carcinoma: pitfalls in nonoperative diagnosis. Titelbaum, D.S., Burke, D.R., Meranze, S.G., Saul, S.H. Radiology. (1988) [Pubmed]
  29. Usefulness of novel imaging modalities in diagnosis of focal nodular hyperplasia of the liver. Nishigaki, Y., Tomita, E., Matsuno, Y., Goto, K., Ohnishi, T., Tanaka, Y., Iwai, H., Asano, H., Yasuda, I., Nagura, K., Wakahara, T., Yamada, T. J. Gastroenterol. (1997) [Pubmed]
  30. Expression of steroid hormone receptors in benign hepatic tumors. An immunocytochemical study. Masood, S., West, A.B., Barwick, K.W. Arch. Pathol. Lab. Med. (1992) [Pubmed]
  31. Contrast media in liver sonography: correlation with enhanced dynamic magnetic resonance imaging. Zuiani, C., Vasciaveo, A., Del Frate, C., Bazzocchi, M. European journal of radiology. (1998) [Pubmed]
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