Disease relevance of Scedosporium

• Keratitis caused by Scedosporium apiospermum successfully treated with a cornea transplant and voriconazole [1].
• An immunocompromised patient with an invasive soft tissue infection due to Scedosporium apiospermum was successfully treated with voriconazole and surgical debridement [2].
• Successful treatment of Scedosporium apiospermum suppurative arthritis with itraconazole [3].
• Treatment of Scedosporium apiospermum brain abscesses with posaconazole [4].
• Eradication of scedosporium proved difficult, but under combined treatment with itraconazole and fluconazole this opportunistic infection did not disseminate [5].

High impact information on Scedosporium

• We describe six inpatients with acute non-lymphocytic leukaemia who developed invasive infection with Scedosporium prolificans resistant to amphotericin B, flucytosine, ketoconazole, fluconazole, and itraconazole [6].
• In vitro pharmacodynamics of amphotericin B, itraconazole, and voriconazole against Aspergillus, Fusarium, and Scedosporium spp [7].
• In vitro synergistic interaction between amphotericin B and micafungin against Scedosporium spp [8].
• Species such as Scedosporium prolificans, Fusarium spp., and Scopulariopsis spp. were resistant to the triazole [9].
• Antifungal activities of posaconazole and granulocyte-macrophage colony-stimulating factor ex vivo and in mice with disseminated infection due to Scedosporium prolificans [10].

Chemical compound and disease context of Scedosporium

• We describe a case of cutaneous infection caused by Scedosporium apiospermum in a subject with rheumatoid arthritis and diabetes mellitus who was submitted to long-term therapy with cyclosporin and corticosteroids [11].

Biological context of Scedosporium

• Changes of the metabolic pool constitutents of Monosporium olivaceum -- a mould capable of steroid hydroxylation were examined [12].

Anatomical context of Scedosporium

• Voriconazole and itraconazole showed comparable good activity against several hyaline molds, including Penicillium marneffei and Scedosporium apiospermum, and a number of dematiaceous molds, including Bipolaris australiensis, Cladophialophora bantiana, several Exophiala spp., and several Fonsecaea spp [13].
• We investigated the effects of human interleukin-15 (IL-15) on human polymorphonuclear leukocyte (PMNL) activity against Fusarium solani and Fusarium oxysporum as well as Scedosporium prolificans and Scedosporium apiospermum [14].

Associations of Scedosporium with chemical compounds

• We have evaluated the efficacy of voriconazole (VRC) in a murine model of systemic infection by Scedosporium apiospermum [15].
• The four new antifungals showed activity against Scedosporium apiospermum, and UR-9825 and voriconazole were active against S. prolificans [16].
• In vitro interaction of terbinafine with itraconazole against clinical isolates of Scedosporium prolificans [17].
• In order to develop new approaches to the treatment of the severe and usually fatal infections caused by Scedosporium spp., the in vitro antifungal activities of four novel triazoles (posaconazole, ravuconazole, voriconazole, and UR-9825) and some current antifungals (amphotericin B, ketoconazole, itraconazole, and nystatin) were determined [16].
• A 33 kDa serine proteinase from Scedosporium apiospermum [18].

Gene context of Scedosporium

• Thus, IFN-gamma and GM-CSF, particularly in combination, demonstrate a species- and time-dependent augmentation of PMN responses to Scedosporium spp [19].
• An extracellular proteinase produced by the filamentous fungus Scedosporium apiospermum has been purified and characterized [18].
• Molecular typing of clinical and environmental isolates of Scedosporium prolificans by inter-simple-sequence-repeat polymerase chain reaction [20].

Analytical, diagnostic and therapeutic context of Scedosporium

• The fourth patient had pneumonia caused by Scedosporium apiospermum (the anamorph form of the fungus Pseudallescheria boydii) during consolidation chemotherapy which was successfully treated with itraconazole [21].
• We report a case of a 50-year-old Caucasian male with lymphocutaneous and presumed pulmonary Scedosporium infection 4 years after renal transplantation that was successfully treated with voriconazole and discontinuation of immunosuppression [22].

References