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MeSH Review

Castor Bean

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Disease relevance of Castor Bean


High impact information on Castor Bean

  • Immunocytochemical localization of a vacuolar processing enzyme, a 37-kD cysteine proteinase, in the endosperm of maturing castor bean seeds places the enzyme in the vacuolar matrix, where a variety of proproteins is also present [4].
  • Acidification of isolated ricinosomes causes castor bean cysteine endopeptidase activation, with cleavage of the N-terminal propeptide and the C-terminal KDEL motif [5].
  • Thus, C. palaestina PDAT preferentially incorporates vernoloyl groups into TAG, whereas PDAT from castor bean incorporates both ricinoleoyl and vernoloyl groups [6].
  • Programmed cell death in castor bean endosperm is associated with the accumulation and release of a cysteine endopeptidase from ricinosomes [7].
  • A near-full-length casbene synthase cDNA clone, pCS7, was isolated by using a partial cDNA clone, pCS4, to probe a lambda gt10 library constructed from poly(A)+ RNA from elicited castor bean seedlings [8].

Biological context of Castor Bean


Anatomical context of Castor Bean


Associations of Castor Bean with chemical compounds

  • Radiolabeled isocitrate lyase (a glyoxysomal matrix protein) was produced by in vitro transcription of the castor bean cDNA and translation of the RNA in a wheat germ lysate [19].
  • Phosphatidylethanolamine synthesis by castor bean endosperm. Intracellular distribution and characteristics of CTP:ethanolaminephosphate cytidylyltransferase [20].
  • Sequence comparisons with a sesquiterpene cyclase, epi-aristolochene synthase from tobacco, and a diterpene cyclase, casbene synthase from castor bean, demonstrated a significant degree of similarity between these three terpenoid cyclase types, the first three examples of this large family of catalysts to be described from higher plants [21].
  • Variation in the oxygen isotope ratio of phloem sap sucrose from castor bean. Evidence in support of the Péclet effect [22].
  • A cDNA encoding the oleate 12-hydroxylase from castor bean (Ricinus communis L.) has previously been shown to direct the synthesis of small amounts of ricinoleic acid (12-hydroxyoctadec-cis-9-enoic acid) in seeds of transgenic tobacco plants [23].

Gene context of Castor Bean

  • Human castor bean allergy and HLA-A, B, C, DR [24].
  • These results suggest that expression of two tightly linked catalase genes of castor bean, cat1 and cat2, are differentially regulated during development [25].
  • The primary structure of the castor bean PLD exhibits no significant similarities with sequences of other cloned lipolytic enzymes [26].
  • The capacity of the castor bean proteins to bind human IgE was probed with sera from castor bean-sensitive patients and radiolabeled anti-IgE [27].
  • Allergy to castor bean. I. Its relationship to sensitization to common inhalant allergens (atopy) [28].

Analytical, diagnostic and therapeutic context of Castor Bean


  1. Differential regulation of the expression in transgenic tobacco of the gene for beta-glucuronidase under the control of the 5'-upstream regions of two catalase genes from castor bean. Suzuki, M., Miyamoto, R., Hattori, T., Nakamura, K., Asahi, T. Plant Cell Physiol. (1995) [Pubmed]
  2. Ricin depresses cardiac function in the rabbit heart. Ma, L., Hsu, C.H., Patterson, E., Thadani, U., Robinson, C.P. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
  3. Purification and properties of spinach leaf phosphofructokinase 2/fructose 2,6-bisphosphatase. Larondelle, Y., Mertens, E., Van Schaftingen, E., Hers, H.G. Eur. J. Biochem. (1986) [Pubmed]
  4. Molecular characterization of a vacuolar processing enzyme related to a putative cysteine proteinase of Schistosoma mansoni. Hara-Nishimura, I., Takeuchi, Y., Nishimura, M. Plant Cell (1993) [Pubmed]
  5. The ricinosomes of senescing plant tissue bud from the endoplasmic reticulum. Schmid, M., Simpson, D.J., Sarioglu, H., Lottspeich, F., Gietl, C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  6. Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants. Dahlqvist, A., Stahl, U., Lenman, M., Banas, A., Lee, M., Sandager, L., Ronne, H., Stymne, S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. Programmed cell death in castor bean endosperm is associated with the accumulation and release of a cysteine endopeptidase from ricinosomes. Schmid, M., Simpson, D., Gietl, C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. Cloning of casbene synthase cDNA: evidence for conserved structural features among terpenoid cyclases in plants. Mau, C.J., West, C.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  9. Lectin purification on affinity columns containing reductively aminated disaccharides. Baues, R.J., Gray, G.R. J. Biol. Chem. (1977) [Pubmed]
  10. Homologues of a vacuolar processing enzyme that are expressed in different organs in Arabidopsis thaliana. Kinoshita, T., Nishimura, M., Hara-Nishimura, I. Plant Mol. Biol. (1995) [Pubmed]
  11. Nucleotide sequence analysis of a cDNA clone encoding malate synthase of castor bean (Ricinus communis) reveals homology to DAL7, a gene involved in allantoin degradation in Saccharomyces cerevisiae. Rodriguez, D., Ginger, R.S., Baker, A., Northcote, D.H. Plant Mol. Biol. (1990) [Pubmed]
  12. Precursors of ricin and Ricinus communis agglutinin. Glycosylation and processing during synthesis and intracellular transport. Lord, J.M. Eur. J. Biochem. (1985) [Pubmed]
  13. cDNA cloning, characterization, and functional expression of 4S-(-)-limonene synthase from Perilla frutescens. Yuba, A., Yazaki, K., Tabata, M., Honda, G., Croteau, R. Arch. Biochem. Biophys. (1996) [Pubmed]
  14. A cysteine endopeptidase isolated from castor bean endosperm microbodies processes the glyoxysomal malate dehydrogenase precursor protein. Gietl, C., Wimmer, B., Adamec, J., Kalousek, F. Plant Physiol. (1997) [Pubmed]
  15. Pyruvate metabolism in castor-bean mitochondria. Brailsford, M.A., Thompson, A.G., Kaderbhai, N., Beechey, R.B. Biochem. J. (1986) [Pubmed]
  16. Evidence that phosphatidylcholine and phosphatidylethanolamine are synthesized by a single enzyme present in the endoplasmic reticulum of castor-bean endosperm. Lord, J.M. Biochem. J. (1975) [Pubmed]
  17. PTS1-independent targeting of isocitrate lyase to peroxisomes requires the PTS1 receptor Pex5p. Parkes, J.A., Langer, S., Hartig, A., Baker, A. Mol. Membr. Biol. (2003) [Pubmed]
  18. An aspartic endopeptidase is involved in the breakdown of propeptides of storage proteins in protein-storage vacuoles of plants. Hiraiwa, N., Kondo, M., Nishimura, M., Hara-Nishimura, I. Eur. J. Biochem. (1997) [Pubmed]
  19. The carboxyl terminus of isocitrate lyase is not essential for import into glyoxysomes in an in vitro system. Behari, R., Baker, A. J. Biol. Chem. (1993) [Pubmed]
  20. Phosphatidylethanolamine synthesis by castor bean endosperm. Intracellular distribution and characteristics of CTP:ethanolaminephosphate cytidylyltransferase. Wang, X.M., Moore, T.S. J. Biol. Chem. (1991) [Pubmed]
  21. 4S-limonene synthase from the oil glands of spearmint (Mentha spicata). cDNA isolation, characterization, and bacterial expression of the catalytically active monoterpene cyclase. Colby, S.M., Alonso, W.R., Katahira, E.J., McGarvey, D.J., Croteau, R. J. Biol. Chem. (1993) [Pubmed]
  22. Variation in the oxygen isotope ratio of phloem sap sucrose from castor bean. Evidence in support of the Péclet effect. Barbour, M.M., Schurr, U., Henry, B.K., Wong, S.C., Farquhar, G.D. Plant Physiol. (2000) [Pubmed]
  23. Accumulation of ricinoleic, lesquerolic, and densipolic acids in seeds of transgenic Arabidopsis plants that express a fatty acyl hydroxylase cDNA from castor bean. Broun, P., Somerville, C. Plant Physiol. (1997) [Pubmed]
  24. Human castor bean allergy and HLA-A, B, C, DR. Mercier, P., Panzani, R. The Journal of asthma : official journal of the Association for the Care of Asthma. (1988) [Pubmed]
  25. Isolation and characterization of two tightly linked catalase genes from castor bean that are differentially regulated. Suzuki, M., Ario, T., Hattori, T., Nakamura, K., Asahi, T. Plant Mol. Biol. (1994) [Pubmed]
  26. Cloning and expression of phosphatidylcholine-hydrolyzing phospholipase D from Ricinus communis L. Wang, X., Xu, L., Zheng, L. J. Biol. Chem. (1994) [Pubmed]
  27. Allergy to castor bean. II. Identification of the major allergens in castor bean seeds. Thorpe, S.C., Kemeny, D.M., Panzani, R.C., McGurl, B., Lord, M. J. Allergy Clin. Immunol. (1988) [Pubmed]
  28. Allergy to castor bean. I. Its relationship to sensitization to common inhalant allergens (atopy). Thorpe, S.C., Kemeny, D.M., Panzani, R., Lessof, M.H. J. Allergy Clin. Immunol. (1988) [Pubmed]
  29. Chemical, immunochemical, and structural studies of the cross-reactive antigens of Streptococcus mutans AHT and B13. Brown, T.A., Bleiweis, A.S. Infect. Immun. (1979) [Pubmed]
  30. Seasonal occupational asthma in an agricultural products merchant--a case report. Merget, R., Heger, M., Wahl, R., Cromwell, O., Rasche, K., Schultze-Werninghaus, G. Allergy (1994) [Pubmed]
  31. Nonspecific lipid transfer protein in castor bean cotyledon cells: subcellular localization and a possible role in lipid metabolism. Tsuboi, S., Osafune, T., Tsugeki, R., Nishimura, M., Yamada, M. J. Biochem. (1992) [Pubmed]
  32. Specific IgE to castor bean (Ricinus communis) pollen in the sera of clinically sensitive patients to seeds. Singh, A., Panzani, R.C., Singh, A.B. Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología. (1997) [Pubmed]
  33. Asthma in merchant seamen and laboratory workers caused by allergy to castor beans: analysis of allergens. Davison, A.G., Britton, M.G., Forrester, J.A., Davies, R.J., Hughes, D.T. Clin. Allergy (1983) [Pubmed]
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