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Chemical Compound Review

AC1NTT3E     (7Z,16E)-7-ethylidene-4,21- dipropan-2-yl-2...

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Disease relevance of Depsipeptide


High impact information on Depsipeptide


Chemical compound and disease context of Depsipeptide


Biological context of Depsipeptide


Anatomical context of Depsipeptide


Associations of Depsipeptide with other chemical compounds


Gene context of Depsipeptide


Analytical, diagnostic and therapeutic context of Depsipeptide


  1. Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228. Yu, X., Guo, Z.S., Marcu, M.G., Neckers, L., Nguyen, D.M., Chen, G.A., Schrump, D.S. J. Natl. Cancer Inst. (2002) [Pubmed]
  2. T-cell lymphoma as a model for the use of histone deacetylase inhibitors in cancer therapy: impact of depsipeptide on molecular markers, therapeutic targets, and mechanisms of resistance. Piekarz, R.L., Robey, R.W., Zhan, Z., Kayastha, G., Sayah, A., Abdeldaim, A.H., Torrico, S., Bates, S.E. Blood (2004) [Pubmed]
  3. A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia. Byrd, J.C., Marcucci, G., Parthun, M.R., Xiao, J.J., Klisovic, R.B., Moran, M., Lin, T.S., Liu, S., Sklenar, A.R., Davis, M.E., Lucas, D.M., Fischer, B., Shank, R., Tejaswi, S.L., Binkley, P., Wright, J., Chan, K.K., Grever, M.R. Blood (2005) [Pubmed]
  4. Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein. Aron, J.L., Parthun, M.R., Marcucci, G., Kitada, S., Mone, A.P., Davis, M.E., Shen, T., Murphy, T., Wickham, J., Kanakry, C., Lucas, D.M., Reed, J.C., Grever, M.R., Byrd, J.C. Blood (2003) [Pubmed]
  5. Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors. Peart, M.J., Smyth, G.K., van Laar, R.K., Bowtell, D.D., Richon, V.M., Marks, P.A., Holloway, A.J., Johnstone, R.W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB. Marshall, C.G., Broadhead, G., Leskiw, B.K., Wright, G.D. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. Crystal and molecular structure of didemnin B, an antiviral and cytotoxic depsipeptide. Hossain, M.B., van der Helm, D., Antel, J., Sheldrick, G.M., Sanduja, S.K., Weinheimer, A.J. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  8. beta-Lactamase-catalyzed hydrolysis of acyclic depsipeptides and acyl transfer to specific amino acid acceptors. Pratt, R.F., Govardhan, C.P. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  9. Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells. Hong, J.A., Kang, Y., Abdullaev, Z., Flanagan, P.T., Pack, S.D., Fischette, M.R., Adnani, M.T., Loukinov, D.I., Vatolin, S., Risinger, J.I., Custer, M., Chen, G.A., Zhao, M., Nguyen, D.M., Barrett, J.C., Lobanenkov, V.V., Schrump, D.S. Cancer Res. (2005) [Pubmed]
  10. Histone deacetylase inhibitors activate p21(WAF1) expression via ATM. Ju, R., Muller, M.T. Cancer Res. (2003) [Pubmed]
  11. Bortezomib and depsipeptide sensitize tumors to tumor necrosis factor-related apoptosis-inducing ligand: a novel method to potentiate natural killer cell tumor cytotoxicity. Lundqvist, A., Abrams, S.I., Schrump, D.S., Alvarez, G., Suffredini, D., Berg, M., Childs, R. Cancer Res. (2006) [Pubmed]
  12. D-Alanyl-D-lactate and D-alanyl-D-alanine synthesis by D-alanyl-D-alanine ligase from vancomycin-resistant Leuconostoc mesenteroides. Effects of a phenylalanine 261 to tyrosine mutation. Park, I.S., Walsh, C.T. J. Biol. Chem. (1997) [Pubmed]
  13. Mechanism of penicillin action: penicillin and substrate bind covalently to the same active site serine in two bacterial D-alanine carboxypeptidases. Yocum, R.R., Waxman, D.J., Rasmussen, J.R., Strominger, J.L. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  14. Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1). Zhao, Y., Lu, S., Wu, L., Chai, G., Wang, H., Chen, Y., Sun, J., Yu, Y., Zhou, W., Zheng, Q., Wu, M., Otterson, G.A., Zhu, W.G. Mol. Cell. Biol. (2006) [Pubmed]
  15. Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells. Tabe, Y., Konopleva, M., Contractor, R., Munsell, M., Schober, W.D., Jin, L., Tsutsumi-Ishii, Y., Nagaoka, I., Igari, J., Andreeff, M. Blood (2006) [Pubmed]
  16. A potassium ionophore (valinomycin) inhibits lymphocyte proliferation by its effects on the cell membrane. Daniele, R.P., Holian, S.K. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  17. Enhanced adenovirus transgene expression in malignant cells treated with the histone deacetylase inhibitor FR901228. Kitazono, M., Goldsmith, M.E., Aikou, T., Bates, S., Fojo, T. Cancer Res. (2001) [Pubmed]
  18. Novel mechanisms of apoptosis induced by histone deacetylase inhibitors. Peart, M.J., Tainton, K.M., Ruefli, A.A., Dear, A.E., Sedelies, K.A., O'Reilly, L.A., Waterhouse, N.J., Trapani, J.A., Johnstone, R.W. Cancer Res. (2003) [Pubmed]
  19. Inhibition of histone deacetylase suppresses osteoclastogenesis and bone destruction by inducing IFN-beta production. Nakamura, T., Kukita, T., Shobuike, T., Nagata, K., Wu, Z., Ogawa, K., Hotokebuchi, T., Kohashi, O., Kukita, A. J. Immunol. (2005) [Pubmed]
  20. A highly specific D-hydroxyisovalerate dehydrogenase from the enniatin producer Fusarium sambucinum. Lee, C., Görisch, H., Kleinkauf, H., Zocher, R. J. Biol. Chem. (1992) [Pubmed]
  21. Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176). Robey, R.W., Zhan, Z., Piekarz, R.L., Kayastha, G.L., Fojo, T., Bates, S.E. Clin. Cancer Res. (2006) [Pubmed]
  22. The effects of histone deacetylase inhibitors on the induction of differentiation in chondrosarcoma cells. Sakimura, R., Tanaka, K., Yamamoto, S., Matsunobu, T., Li, X., Hanada, M., Okada, T., Nakamura, T., Li, Y., Iwamoto, Y. Clin. Cancer Res. (2007) [Pubmed]
  23. Involvement of the tumor necrosis factor (TNF)/TNF receptor system in leukemic cell apoptosis induced by histone deacetylase inhibitor depsipeptide (FK228). Sutheesophon, K., Nishimura, N., Kobayashi, Y., Furukawa, Y., Kawano, M., Itoh, K., Kano, Y., Ishii, H., Furukawa, Y. J. Cell. Physiol. (2005) [Pubmed]
  24. Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells. Klisovic, M.I., Maghraby, E.A., Parthun, M.R., Guimond, M., Sklenar, A.R., Whitman, S.P., Chan, K.K., Murphy, T., Anon, J., Archer, K.J., Rush, L.J., Plass, C., Grever, M.R., Byrd, J.C., Marcucci, G. Leukemia (2003) [Pubmed]
  25. Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity. Robey, R.W., Honjo, Y., Morisaki, K., Nadjem, T.A., Runge, S., Risbood, M., Poruchynsky, M.S., Bates, S.E. Br. J. Cancer (2003) [Pubmed]
  26. Depsipeptide (FR901228): a novel therapeutic agent with selective, in vitro activity against human B-cell chronic lymphocytic leukemia cells. Byrd, J.C., Shinn, C., Ravi, R., Willis, C.R., Waselenko, J.K., Flinn, I.W., Dawson, N.A., Grever, M.R. Blood (1999) [Pubmed]
  27. DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. Zhu, W.G., Lakshmanan, R.R., Beal, M.D., Otterson, G.A. Cancer Res. (2001) [Pubmed]
  28. Synergistic antineoplastic action of DNA methylation inhibitor 5-AZA-2'-deoxycytidine and histone deacetylase inhibitor depsipeptide on human breast carcinoma cells. Primeau, M., Gagnon, J., Momparler, R.L. Int. J. Cancer (2003) [Pubmed]
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