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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Computers

 
 
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High impact information on Computers

  • Our study was designed to test whether a digital computer program could correctly predict amikacin serum concentrations in the clinical setting [1].
  • 99m-Tc-human serum albumin was injected via a central venous catheter into the superior vena cava and precordial activity recorded with a gamma scintillation camera interfaced to a small digital computer [2].
  • The method uses orthoiodohippuric acid (hippuran) administered IV, with scintillation imaging, and curve analysis by a digital computer [3].
  • Theta/gamma coding therefore bears some relationship to the concept of "word" in digital computers, with word length corresponding to the number of gamma cycles within a theta cycle, and discrete phase corresponding to the ordered "place" within a word [4].
  • The initial fluoride distribution was found to be similar to that of [77Br]bromide, a known extracellular-fluid (ECF) tracer, in agreement with the hypothesis underlying the model, and the measured uptake rate in rat bones compared well with the digital computer solution [5].
 

Biological context of Computers

 

Anatomical context of Computers

 

Associations of Computers with chemical compounds

  • A system for individualized dosing of intravenous aminophylline using a programmable calculator [12].
  • A glucose control system consisting of a single in-line glucose sensor, concentrated glucose solution, and computer hardware and software were developed [13].
  • Five trained mongrel dogs breathed from a mask as the inspired gas was alternated between air and O2 for multiple cycles, and continuous time series records of HR and oxyhemoglobin saturation were recorded on a digital computer and analyzed by the technique of ensemble averaging [14].
  • Image data taken by the CCD camera were fed into a desktop digital computer; then the fractal dimension of each skin cross section was determined on the basis of the box-counting algorithm [15].
  • Evaluation of environmental polychlorobiphenyls and DDE in terms of mixtures of commercial preparations from peak heights of packed-column gas chromatograms using a programmable calculator [16].
 

Gene context of Computers

  • Color images obtained directly from the CRT display of a digital computer were used to assess the passage of radionuclides through the heart [17].
  • This paper describes the incorporation of a SMAC (Technicon) analyzer into data-processing techniques that have been developed on existing computer hardware during several years [18].
  • Bedside determination of bicarbonate and base excess, blood oxygen saturation and content, VD/VT, and P50 using a programmable calculator [19].
  • Epidemiologic programs for computers and calculators. Simple algorithms for the representation of deterministic and stochastic versions of the Reed-Frost epidemic model using a programmable calculator [20].
  • Direct curve-fitting methods using a digital computer have been employed to analyze the calibration curves of commercial kits for the assay of digoxin, digitoxin, insulin, B12, and renin activity (angiotensin) [21].
 

Analytical, diagnostic and therapeutic context of Computers

References

  1. Amikacin serum concentrations: prediction of levels and dosage guidelines. Sarubbi, F.A., Hull, J.H. Ann. Intern. Med. (1978) [Pubmed]
  2. Nontraumatic determination of left ventricular ejection fraction by radionuclide angiocardiography. Schelbert, H.R., Verba, J.W., Johnson, A.D., Brock, G.W., Alazraki, N.P., Rose, F.J., Ashburn, W.L. Circulation (1975) [Pubmed]
  3. Use of radionuclide imaging in the early diagnosis and treatment of renal allograft rejection. Mandel, S.R., Mattern, W.D., Staab, E., Johnson, G. Ann. Surg. (1975) [Pubmed]
  4. The theta/gamma discrete phase code occuring during the hippocampal phase precession may be a more general brain coding scheme. Lisman, J. Hippocampus. (2005) [Pubmed]
  5. Studies of skeletal tracer kinetics: II. evaluation of a five-compartment model of [18F]fluoride kinetics in rats. Charkes, N.D., Brookes, M., Makler, P.T. J. Nucl. Med. (1979) [Pubmed]
  6. Studies of skeletal tracer kinetics. I. Digital-computer solution of a five-compartment model of [18F] fluoride kinetics in humans. Charkes, N.D., Makler, P.T., Philips, C. J. Nucl. Med. (1978) [Pubmed]
  7. Kinetics of product inhibition in alcohol fermentation. Reprinted from Biotechnology and Bioengineering, Vol. X, Issue 6, Pages 845-864 (1968). Aiba, S., Shoda, M., Nagatani, M. Biotechnol. Bioeng. (2000) [Pubmed]
  8. Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography. Bohannon, N.J., Corp, E.S., Wilcox, B.J., Figlewicz, D.P., Dorsa, D.M., Baskin, D.G. Brain Res. (1988) [Pubmed]
  9. Theoretical studies on tricyclic antidepressants: III. Analysis of stereospecificity. Sundaram, K., Mahajan, S. Physiol. Chem. Phys. (1981) [Pubmed]
  10. Acute effect of manidipine on renal blood flow measured by pulsed-Doppler flowmeter in normal subjects. Kasai, Y., Sheu, H.L., Yabe, T., Saso, S., Abe, K. Blood pressure. Supplement. (1992) [Pubmed]
  11. Bromsulphalein plasma kinetics after obstruction of the common bile duct in rats: curve fitting with a programmable calculator. Ristanović, D., Ristanović, D., Malesević, J., Milutinović, B. Comput. Biol. Med. (1983) [Pubmed]
  12. A system for individualized dosing of intravenous aminophylline using a programmable calculator. Mitsuoka, J.C., Fleck, R.J. Pediatrics (1984) [Pubmed]
  13. Continuous glucose monitoring and control in a rotating wall perfused bioreactor. Xu, Y., Sun, J., Mathew, G., Jeevarajan, A.S., Anderson, M.M. Biotechnol. Bioeng. (2004) [Pubmed]
  14. Response time, autonomic mediation, and reversibility of hyperoxic bradycardia in conscious dogs. Lodato, R.F., Jubran, A. J. Appl. Physiol. (1993) [Pubmed]
  15. Evaluation of skin damage caused by percutaneous absorption enhancers using fractal analysis. Obata, Y., Sesumi, T., Takayama, K., Isowa, K., Grosh, S., Wick, S., Sitz, R., Nagai, T. Journal of pharmaceutical sciences. (2000) [Pubmed]
  16. Evaluation of environmental polychlorobiphenyls and DDE in terms of mixtures of commercial preparations from peak heights of packed-column gas chromatograms using a programmable calculator. Eder, G. J. Chromatogr. (1976) [Pubmed]
  17. Assessment of radionuclide angiocardiograms using color/time images. Gates, G.F. Radiology. (1978) [Pubmed]
  18. Incorporation of a SMAC analyzer into the data-processing procedures of a computer-assisted laboratory. Undrill, P.E., Stroud, R.E., Paterson, N. Clin. Chem. (1979) [Pubmed]
  19. Bedside determination of bicarbonate and base excess, blood oxygen saturation and content, VD/VT, and P50 using a programmable calculator. Wilkinson, P.L. Crit. Care Med. (1979) [Pubmed]
  20. Epidemiologic programs for computers and calculators. Simple algorithms for the representation of deterministic and stochastic versions of the Reed-Frost epidemic model using a programmable calculator. Franco, E.L., Simons, A.R. Am. J. Epidemiol. (1986) [Pubmed]
  21. Precision of radioimmunoassay with emphasis on curve-fitting procedures. Hidalgo, J.U., Maduell, C.R., Bloch, T., Spohrer, L.R., Wooten, M. Seminars in nuclear medicine. (1975) [Pubmed]
  22. Data point weighting in pharmacokinetic analysis: intravenous paracetamol in man. Clements, J.A., Prescott, L.F. J. Pharm. Pharmacol. (1976) [Pubmed]
  23. Semi-automated radioimmunoassays for total serum thyroxine and triiodothyronine. Challand, G.S., Ratcliffe, W.A., Ratcliffe, J.G. Clin. Chim. Acta (1975) [Pubmed]
  24. Use of the handheld programmable calculator in the preparation of TPN solutions. DiDonato, L.J. Hospital pharmacy. (1983) [Pubmed]
  25. CT-fluoroscopy: Tool or gimmick? Froelich, J.J., Wagner, H.J. Cardiovascular and interventional radiology. (2001) [Pubmed]
 
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