Disease relevance of Pleural Diseases

• This study used enzyme-linked immunoassay (ELISA) to measure 90K in pleural effusions (PEs) and sera from patients with MM (n=28), lung cancer (LC) (n=14) and benign pleural disease (BPD) (n=15) [1].
• We conclude that radiographic evidence of either parenchymal or pleural disease in subjects exposed to asbestos is significantly related to the presence of chest pain, particularly anginal pain [2].
• We hypothesized that manganese superoxide dismutase (MnSOD), known to be induced in rat mesothelial cells by asbestos fibers, cytokines, and hyperoxia, may also be induced in asbestos-related pleural diseases such as mesothelioma [3].
• STUDY OBJECTIVES: To measure interleukin-1 beta (IL-1 beta) levels in pleural effusions of different etiologies and their relationship with several pleural inflammatory parameters, and to verify whether IL-1 beta can be used as diagnostic marker in the differential diagnosis of pleural diseases [4].
• We investigated the expression of b-FGF in patients affected with malignant and non-malignant pleural diseases and presenting clinically with non-specific signs and symptoms [5].

High impact information on Pleural Diseases

• Effects of intrapleural heparin or urokinase on the extent of tetracycline-induced pleural disease [6].
• PURPOSE: To evaluate the accuracy of fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) in differentiation of pleural malignancy and cancer-unrelated pleural disease in patients with non-small cell lung cancer (NSCLC) and pleural abnormalities at computed tomography (CT) [7].
• The significance of Fn and Tn in human pleural mesothelial cells and pleural diseases is unclear [8].
• We hypothesized that pleural mesothelial cells (PMCs) are an important source of IL-6 in pleural diseases [9].
• Gallium-67 thoracic scan and pleural disease in asbestos workers [10].

Chemical compound and disease context of Pleural Diseases

• A counter hypothesis, based on the detection of very small quantities of chrysotile and tremolite in strata samples and human lung tissue, postulates a significant role of these minerals as one of several factors contributing to pleural disease [11].
• METHODS: The Japan Clinical Oncology Group conducted a phase III trial for a 3-year period starting from October 1994 to determine whether intraoperative intrapleural hypotonic cisplatin treatment could effectively control pleural disease and thereby prolong the survival of these patients [12].
• Abnormalities of pulmonary function and pleural disease among titanium metal production workers [13].
• Mineral fiber-related pleural diseases were not detected in those people who were exposed to sepiolite dust [14].
• 0. Because of the high predictive values of the test, measurement of lactate concentration in pleural fluid offers a rapid and useful information in the differentiation between infectious and non-infectious pleural disease [15].

Anatomical context of Pleural Diseases

• In a previous investigation of lung function in patients with rheumatoid arthritis (RA), we observed that some patients had significant dysfunction of their chest wall mechanics without pleural disease that could contribute to their respiratory symptoms [16].
• Elevated ADA activity has been found in pleural effusions of patients with pleural tuberculosis relative to those from patients with nontuberculous pleural diseases, and is mainly associated with cellular host factors such as monocyte-macrophages or lymphocytes [17].
• OBJECTIVE: In order to investigate the role of eotaxin in pleural diseases, we measured eotaxin in pleural effusions and studied the relationship between eotaxin levels and recruitment of inflammatory cells, particularly eosinophils [18].

Gene context of Pleural Diseases

• It is unlikely that TNF alpha is the sole stimulus for the IL-8 production in pleural disease states [19].
• Paired pleural fluid and serum CEA determinations were performed in 107 patients, 53 with malignant and 54 with non-malignant pleural disease [20].
• Physicians treating patients with COPD and associated pleural disease should be aware of this rare condition, since percutaneous needle drainage may be associated with serious life-threatening complications [21].
• In many effusions in this study, a concomitant T-lymphocytosis was observed with a non-specific increase in the CD4/CD8 ratio, as known for other pleural diseases [22].
• Serum and pleural fluid levels of orosomucoid, alpha 2-macroglobulin, IgG, IgA, and IgM were measured in 36, 29, and nine patients suffering from malignant, tuberculous, and non-malignant, non-inflammatory pleural disease, respectively [23].

Analytical, diagnostic and therapeutic context of Pleural Diseases

• The concentration of CEA was determined by radioimmunoassay (RIA) in pleural fluid of 213 adult patients, of which 140 had malignant pleural disease and 73 had nonmalignant pleural disease [24].
• Seven previously heavily pretreated patients with malignant pleural disease and effusions were treated with 12 courses of combination intrapleural chemotherapy with cisplatin, cytarabine, and doxorubicin [25].

References