Disease relevance of Labyrinthitis

• Ganciclovir prophylaxis for cochlear pathophysiology during experimental guinea pig cytomegalovirus labyrinthitis [1].
• Prophylactic ganciclovir thus can protect the cochlea from the histopathologic changes and hearing loss normally associated with experimental guinea pig cytomegalovirus labyrinthitis [1].
• Meningogenic labyrinthitis and otosclerosis were associated with the greatest loss of ganglion cells [2].
• A case is reported of a patient with bilateral endophthalmitis, meningitis, sensorineural deafness, labyrinthitis, and septicaemia due to Streptococcus suis type II (group R) [3].
• The most frequently occurring findings were otitis media (71.1%), otosclerosis (43.4%), endolymphatic hydrops (38.8%), labyrinthitis (25.0%), and cancer (24.3%) [4].

High impact information on Labyrinthitis

• In addition, we show that FasL is upregulated in adult cochlear cells after induction of a sterile labyrinthitis in vivo [5].
• Gadolinium-enhanced T1-weighted images were needed to detect enhancing pathology such as labyrinthitis and tumors inside the membranous labyrinth [6].
• All 4 patients who failed to receive steroid therapy developed labyrinthitis ossificans [7].
• Occasionally, there is serous labyrinthitis, which might lead to partial sensorineural hearing loss [8].
• Once toxic substances or inflammatory mediators such as cytokines and nitric oxide enter the inner ear, various inner ear sequelae such as labyrinthitis, endolymphatic hydrops, sensorineural hearing loss or more insidious diseases can occur [9].

Chemical compound and disease context of Labyrinthitis

• Effects of cyclophosphamide on the pathogenesis of cytomegalovirus-induced labyrinthitis [10].
• It is concluded that ceftazidime should be a very useful agent in the treatment of bacterial labyrinthitis caused by susceptible organisms [11].
• On the basis of these experimental findings, we feel that cefuroxime has considerable potential as an antibacterial agent for the treatment or prevention of bacterial labyrinthitis [12].
• Possible involvement of free radicals in lipopolysaccharide-induced labyrinthitis in the guinea pig: a morphological and functional investigation [13].
• The present case is unusual and differs somewhat from previously reported cases of the primary squamous cell carcinoma of the middle ear in three respects: 1) an extensive invasion of the cancer into the membranous labyrinth, 2) cholesterol deposits in the cochlear spiral canal, and 3) presence of ossifying labyrinthitis [14].

Anatomical context of Labyrinthitis

• Idiopathic sudden sensorineural hearing loss and postnatal viral labyrinthitis: a statistical comparison of temporal bone findings [15].
• Th1: mediator lymphocytes in experimental autoimmune labyrinthitis [16].
• In the pathological study obliteration of the round window niche occurred as a congenital anomaly, in otosclerosis, chronic otitis media and as an end result in suppurative labyrinthitis [17].
• We report the case of a 67-year-old man who developed complete bilateral deafness caused by labyrinthitis and radiation-induced neuritis of the acoustic nerve after postoperative radiotherapy of a nasopharyngeal carcinoma [18].
• The expression of vascular cell adhesion molecule-1 (VCAM-1), alpha4-integrin and L-selectin was dynamically observed using an immunohistochemical approach during labyrinthitis induced by inoculation of keyhole limpet hemocyanin into the scala tympani of animals that had been systemically sensitized to it [19].

Gene context of Labyrinthitis

• The most common causes of BPPV are post-traumatic following head injury and post-viral labyrinthitis [20].
• The in vivo effect of systemic administration of monoclonal antibody (mAb) against ICAM-1 (alphaICAM-1) in experimental immune-mediated labyrinthitis was evaluated [21].

References