Disease relevance of Glaucoma, Angle-Closure

• Autosomal dominant nanophthalmos (NNO1) with high hyperopia and angle-closure glaucoma maps to chromosome 11 [1].
• PARTICIPANTS: A 10-year-old Japanese boy (proband) was seen with secondary angle-closure glaucoma (iris bombe), uveitis, skin rashes, and camptodactyly [2].
• Thymoxamine test. Differentiating angle-closure glaucoma form open-angle glaucoma with narrow angles [3].
• Retinal degeneration with nanophthalmos, cystic macular degeneration, and angle closure glaucoma. A new recessive syndrome [4].
• CASE SUMMARY: A 66-year-old while woman diagnosed with narrow-angle glaucoma showed an increase in intraocular pressure and experienced orbital pain and blurred vision after the initiation of fluvoxamine for tension-type headache [5].

High impact information on Glaucoma, Angle-Closure

• Nebulised ipratropium bromide and salbutamol causing closed-angle glaucoma [6].
• Closed-angle glaucoma in patient on disopyramide [7].
• Angle closure glaucoma precipitated by atropine [8].
• Although there are some similarities in the phenotype of POAG and in particular chronic primary angle-closure glaucoma (PACG), little is known about the role of MYOC in the causation of PACG [9].
• Eyes of patients with either congenital juvenile or angle-closure glaucoma showed COX-2 expression indistinguishable from control eyes [10].

Chemical compound and disease context of Glaucoma, Angle-Closure

• Acute angle-closure glaucoma and paroxetine [11].
• Intraocular pressure-reducing effects and safety of latanoprost versus timolol in patients with chronic angle-closure glaucoma [12].
• OBJECTIVE: To demonstrate that the intraocular pressure (IOP)-reducing effect of latanoprost once daily is at least as good as that of timolol twice daily in patients with chronic angle-closure glaucoma (CACG) [12].
• Phenylephrine should not be used in patients with narrow-angle glaucoma, and it is also contraindicated in patients taking monoamine oxidase inhibitors or tricyclic antidepressants [13].
• Of patients with chronic angle-closure glaucoma, IOP was similar to prelaser values in 11 (69%) of 16 eyes treated with 0.5% (P > 0.7) and 12 (80%) of 15 eyes treated with 1.0% apraclonidine (P > 0.3) [14].

Biological context of Glaucoma, Angle-Closure

• OBJECTIVE: To compare the intraocular pressure (IOP)-reducing effect and side effects of 0.005% latanoprost once daily to 0.5% timolol twice daily in patients with primary chronic angle closure glaucoma (CACG) [15].
• SETTING: Ophthalmology Department, Groote Schuur Hospital, Cape Town, South Africa. METHODS: This retrospective study comprised 17 patients (19 eyes) with primary angle-closure glaucoma who had ECCE and posterior chamber IOL implantation [16].
• Topiramate, a drug that enhances GABAergic transmission, has been associated with cases of acute closed angle glaucoma, while tiagabine, a GABA uptake inhibitor, has been investigated for a potential GABAergic effect on the visual field [17].

Anatomical context of Glaucoma, Angle-Closure

• Thymoxamine was useful in individuals with narrow anterior chamber angles who were at risk of acute closed-angle glaucoma following dilation with an adrenergic agent [18].
• The aim of this study was to evaluate the efficacy of 0.005% latanoprost in lowering intraocular pressure (IOP) in patients with chronic angle-closure glaucoma (CACG) and no visible ciliary-body face [19].
• METHODS: Concentrations of VEGF were measured using a sandwich ELISA kit in aqueous humor aspirates taken during anterior segment surgery from 87 patients, of whom 54 had glaucoma (27 primary open-angle glaucoma, 8 angle-closure glaucoma, 16 exfoliative glaucoma) and 33 had cataract only [20].
• PURPOSE: To investigate the hemodynamic changes of ophthalmic and central retinal artery (OA, CRA) in Primary Angle-closure Glaucoma (PACG) and the effects of intraocular pressure (IOP) on the retrobulbar hemodynamics [21].

Gene context of Glaucoma, Angle-Closure

• RESULTS: Among the 8 members of this family who were characterized as having ODDD, 2 showed chronic angle-closure glaucoma, and 1 had open-angle glaucoma [22].
• Angle-closure glaucoma as an initial presentation of systemic lupus erythematosus [23].
• A 40-year-old homosexual man presented with acute myopia and bilateral angle-closure glaucoma [24].
• OBJECTIVE: To determine the prevalence of primary angle closure glaucoma in the so-called Cape people of mixed ethnic background [25].
• Acute angle closure glaucoma secondary to a luxated lens associated with retinitis pigmentosa [26].

Analytical, diagnostic and therapeutic context of Glaucoma, Angle-Closure

• PURPOSE: To evaluate and compare levels of patient discomfort and complications during phacoemulsification with implantation of a foldable intraocular lens (IOL) under topical lidocaine hydrochloride in patients with and without various forms of chronic open-angle and chronic angle-closure glaucoma [27].
• A 66-year-old woman with asthma returned to the emergency department with bilateral acute angle-closure glaucoma less than 48 hours after successful treatment with nebulized albuterol sulfate and ipratropium bromide given by metered-dose inhaler [28].
• Efficacy of latanoprost as an adjunct to medical therapy for residual angle-closure glaucoma after iridectomy [29].
• Acute angle closure glaucoma following the use of intranasal cocaine during dacryocystorhinostomy [30].
• RESULTS: In a 75-year-old woman with asthma, acute angle-closure glaucoma in the right eye was probably caused by local absorption of albuterol after nebulizer administration [31].

References