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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Colonic Polyps

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Disease relevance of Colonic Polyps


High impact information on Colonic Polyps

  • Here we show that the colonic polyp number is about six times higher in Apc+/Delta716 Cdx2+/- compound mutant mice [6].
  • It is not known if the rate of colonic cell proliferation differs among individuals with or without a history of colonic polyps or cancer and if proliferation changes in response to beta-carotene [7].
  • Elevation of N-myristoyltransferase activity was present in all tumors, including colonic polyps [8].
  • Significant increases in tyrosine kinase activity were seen as early as in colonic polyps of high malignant potential [9].
  • Fifty-seven patients who had had colonic polyps removed were randomly assigned to two groups to receive either sodium sulfate (27 patients) or a placebo (25 patients) at a mean dose of 4 g/day for 14 days [10].

Chemical compound and disease context of Colonic Polyps


Biological context of Colonic Polyps


Anatomical context of Colonic Polyps


Gene context of Colonic Polyps


Analytical, diagnostic and therapeutic context of Colonic Polyps


  1. Alleles of the APC gene: an attenuated form of familial polyposis. Spirio, L., Olschwang, S., Groden, J., Robertson, M., Samowitz, W., Joslyn, G., Gelbert, L., Thliveris, A., Carlson, M., Otterud, B. Cell (1993) [Pubmed]
  2. Skin fibroblasts from individuals hemizygous for the familial adenopolyposis susceptibility gene show delayed crisis in vitro. Chen, S.Z., Kazim, D., Kraveka, J., Pollack, R.E. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  3. Association of APC gene mutations and histological characteristics of colorectal adenomas. De Benedetti, L., Sciallero, S., Gismondi, V., James, R., Bafico, A., Biticchi, R., Masetti, E., Bonelli, L., Heouaine, A., Picasso, M. Cancer Res. (1994) [Pubmed]
  4. A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation. Bruce, W.R., Cirocco, M., Giacca, A., Kim, Y.I., Marcon, N., Minkin, S. Br. J. Cancer (2005) [Pubmed]
  5. A de novo deletion of chromosome 5q causing familial adenomatous polyposis, dysmorphic features, and mild mental retardation. Raedle, J., Friedl, W., Engels, H., Koenig, R., Trojan, J., Zeuzem, S. Am. J. Gastroenterol. (2001) [Pubmed]
  6. Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Aoki, K., Tamai, Y., Horiike, S., Oshima, M., Taketo, M.M. Nat. Genet. (2003) [Pubmed]
  7. Effect of beta-carotene supplementation on indices of colonic cell proliferation. Frommel, T.O., Mobarhan, S., Doria, M., Halline, A.G., Luk, G.D., Bowen, P.E., Candel, A., Liao, Y. J. Natl. Cancer Inst. (1995) [Pubmed]
  8. Increased N-myristoyltransferase activity observed in rat and human colonic tumors. Magnuson, B.A., Raju, R.V., Moyana, T.N., Sharma, R.K. J. Natl. Cancer Inst. (1995) [Pubmed]
  9. Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer. Talamonti, M.S., Roh, M.S., Curley, S.A., Gallick, G.E. J. Clin. Invest. (1993) [Pubmed]
  10. Effects of sodium sulfate on fecal pH and proliferation of colonic mucosa in patients at high risk for colon cancer. Kashtan, H., Gregoire, R.C., Bruce, W.R., Hay, K., Stern, H.S. J. Natl. Cancer Inst. (1990) [Pubmed]
  11. Effect of sulindac on sporadic colonic polyps. Ladenheim, J., Garcia, G., Titzer, D., Herzenberg, H., Lavori, P., Edson, R., Omary, M.B. Gastroenterology (1995) [Pubmed]
  12. Unscheduled DNA synthesis in mononuclear leukocytes from patients with colorectal polyps. Pero, R.W., Ritchie, M., Winawer, S.J., Markowitz, M.M., Miller, D.G. Cancer Res. (1985) [Pubmed]
  13. Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. Oshima, M., Murai, N., Kargman, S., Arguello, M., Luk, P., Kwong, E., Taketo, M.M., Evans, J.F. Cancer Res. (2001) [Pubmed]
  14. Micronutrients and cancer risk. Willett, W.C. Am. J. Clin. Nutr. (1994) [Pubmed]
  15. beta-Carotene supplementation results in an increased serum and colonic mucosal concentration of beta-carotene and a decrease in alpha-tocopherol concentration in patients with colonic neoplasia. Mobarhan, S., Shiau, A., Grande, A., Kolli, S., Stacewicz-Sapuntzakis, M., Oldham, T., Liao, Y., Bowen, P., Dyavanapalli, M., Kazi, N. Cancer Epidemiol. Biomarkers Prev. (1994) [Pubmed]
  16. Growth hormone inhibits apoptosis in human colonic cancer cell lines: antagonistic effects of peroxisome proliferator activated receptor-gamma ligands. Bogazzi, F., Ultimieri, F., Raggi, F., Russo, D., Vanacore, R., Guida, C., Brogioni, S., Cosci, C., Gasperi, M., Bartalena, L., Martino, E. Endocrinology (2004) [Pubmed]
  17. NSAID inhibition of GI cancer growth: clinical implications and molecular mechanisms of action. Husain, S.S., Szabo, I.L., Tamawski, A.S. Am. J. Gastroenterol. (2002) [Pubmed]
  18. Insertion/deletion polymorphism and other restriction fragment length polymorphisms in the MCC gene. Miyoshi, Y., Nishisho, I., Miki, Y., Mori, T., Kinzler, K.W., Vogelstein, B., Nakamura, Y. Jpn. J. Cancer Res. (1992) [Pubmed]
  19. Association between 6-n-propylthiouracil (PROP) bitterness and colonic neoplasms. Basson, M.D., Bartoshuk, L.M., Dichello, S.Z., Panzini, L., Weiffenbach, J.M., Duffy, V.B. Dig. Dis. Sci. (2005) [Pubmed]
  20. Clinical and genetic studies of Birt-Hogg-Dubé syndrome. Khoo, S.K., Giraud, S., Kahnoski, K., Chen, J., Motorna, O., Nickolov, R., Binet, O., Lambert, D., Friedel, J., Lévy, R., Ferlicot, S., Wolkenstein, P., Hammel, P., Bergerheim, U., Hedblad, M.A., Bradley, M., Teh, B.T., Nordenskjöld, M., Richard, S. J. Med. Genet. (2002) [Pubmed]
  21. Changes in the expression of the peroxisome proliferator-activated receptor gamma gene in the colonic polyps and colonic mucosa of acromegalic patients. Bogazzi, F., Ultimieri, F., Raggi, F., Russo, D., Viacava, P., Cecchetti, D., Costa, A., Brogioni, S., Cosci, C., Gasperi, M., Bartalena, L., Martino, E. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  22. Immunomodulatory effect of beta-carotene on T lymphocyte subsets in patients with resected colonic polyps and cancer. Kazi, N., Radvany, R., Oldham, T., Keshavarzian, A., Frommel, T.O., Libertin, C., Mobarhan, S. Nutrition and cancer. (1997) [Pubmed]
  23. Ultrastructure of the absorptive cell glycocalyx in hyperplastic colonic polyps after staining with alcian blue and high iron diamine. Albedi, F.M., Ciaralli, F., Taruscio, D., Giuliani, A. Histochem. J. (1989) [Pubmed]
  24. Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence. Smith, A.M., Watson, S.A. Gut (2000) [Pubmed]
  25. Increased membrane type 1 matrix metalloproteinase expression from adenoma to colon cancer: a possible mechanism of neoplastic progression. Malhotra, S., Newman, E., Eisenberg, D., Scholes, J., Wieczorek, R., Mignatti, P., Shamamian, P. Dis. Colon Rectum (2002) [Pubmed]
  26. Analysis of cyclin D1 and CDK expression in colonic polyps containing neoplastic foci: a study of proteins extracted from paraffin sections. Izawa, H., Yamamoto, H., Ikeda, M., Ikeda, K., Fukunaga, H., Yasui, M., Ikenaga, M., Sekimoto, M., Monden, T., Matsuura, N., Monden, M. Oncol. Rep. (2002) [Pubmed]
  27. Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon. Hardy, R.G., Tselepis, C., Hoyland, J., Wallis, Y., Pretlow, T.P., Talbot, I., Sanders, D.S., Matthews, G., Morton, D., Jankowski, J.A. Gut (2002) [Pubmed]
  28. Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Zhang, X., Gaspard, J.P., Chung, D.C. Cancer Res. (2001) [Pubmed]
  29. Colonic hamartomas in tuberous sclerosis. Devroede, G., Lemieux, B., Massé, S., Lamarche, J., Herman, P.S. Gastroenterology (1988) [Pubmed]
  30. Computerized detection of colonic polyps at CT colonography on the basis of volumetric features: pilot study. Yoshida, H., Masutani, Y., MacEneaney, P., Rubin, D.T., Dachman, A.H. Radiology. (2002) [Pubmed]
  31. Localization by immunoperoxidase and estimation by radioimmunoassay of carcinoembryonic antigen in colonic polyps. Sharkey, R.M., Hagihara, P.F., Goldenberg, D.M. Br. J. Cancer (1977) [Pubmed]
  32. Surface normal overlap: a computer-aided detection algorithm with application to colonic polyps and lung nodules in helical CT. Paik, D.S., Beaulieu, C.F., Rubin, G.D., Acar, B., Jeffrey, R.B., Yee, J., Dey, J., Napel, S. IEEE transactions on medical imaging. (2004) [Pubmed]
  33. Knowledge of the adenomatous polyposis coli gene and its clinical application. Petersen, G.M. Ann. Med. (1994) [Pubmed]
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