Chemical Compound Review:
TEPA 1-[bis(aziridin-1- yl)phosphoryl]aziridine
Synonyms:
Aphoxide, TAPO, CHEMBL670, NSC-9717, HSDB 1011, ...
- Phase I/pharmacokinetic reevaluation of thioTEPA. O'Dwyer, P.J., LaCreta, F., Engstrom, P.F., Peter, R., Tartaglia, L., Cole, D., Litwin, S., DeVito, J., Poplack, D., DeLap, R.J. Cancer Res. (1991)
- In the search for new anticancer drugs. 17. Linear and cyclic polyether analogues of N,N:N',N':N'',N''-tri-1,2-ethanediylphosphoric triamide and N,N:N',N':N'',N''-tri-1,2-ethanediylphosphorothioic triamide. Sosnovsky, G., Lukszo, J., Rao, N.U. J. Med. Chem. (1986)
- Effects of alkylating agents on lymphocytes from controls and from patients with Fanconi's anemia. Studies of sister chromatid exchanges, chromosome aberrations, and kinetics of cell division. Novotná, B., Goetz, P., Surkova, N.I. Hum. Genet. (1979)
- Mutagenic effect of epichlorohydrin. I. Testing on human lymphocytes in vitro in comparison with TEPA. Kucerová, M., Polívková, Z., Srám, R., Matousek, V. Mutat. Res. (1976)
- Long-term pharmacokinetics of thio-TEPA, TEPA and total alkylating activity following i.v. bolus administration of thio-TEPA in ovarian cancer patients. Hagen, B., Neverdal, G., Walstad, R.A., Nilsen, O.G. Cancer Chemother. Pharmacol. (1990)
- A search for new metabolites of N,N',N''-triethylenethiophosphoramide. van Maanen, M.J., Tijhof, I.M., Damen, J.M., Versluis, C., van den Bosch, J.J., Heck, A.J., Rodenhuis, S., Beijnen, J.H. Cancer Res. (1999)
- Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid. O'Dwyer, P.J., LaCreta, F., Nash, S., Tinsley, P.W., Schilder, R., Clapper, M.L., Tew, K.D., Panting, L., Litwin, S., Comis, R.L. Cancer Res. (1991)
- N,N',N''-triethylenethiophosphoramide (thio-TEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents. Ng, S.F., Waxman, D.J. Cancer Res. (1991)
- Interaction of N,N',N''-triethylenethiophosphoramide and N,N',N''-triethylenephosphoramide with cellular DNA. Cohen, N.A., Egorin, M.J., Snyder, S.W., Ashar, B., Wietharn, B.E., Pan, S.S., Ross, D.D., Hilton, J. Cancer Res. (1991)
- Banding technique used for the detection of chromosomal aberrations induced by radiation and alkylating agents TEPA and epichlorohydrin. Kucerová, M., Polívková, Z. Mutat. Res. (1976)
- Mutagenicity studies with nitrofurans. I. Mutagenicity of nitrofurylacrylic acid for mammals. Srám, R.J., Rössner, P., Zhurkov, V.S., Kodýtková, I. Mutat. Res. (1979)
- Influence of the tissue distribution of ThioTEPA and its metabolite, TEPA, on the response of murine colon tumours. Bibby, M.C., McDermott, B.J., Double, J.A., Phillips, R.M., Loadman, P.M., Burgess, L. Cancer Chemother. Pharmacol. (1987)
- Cellular pharmacology of N,N',N''-triethylene thiophosphoramide. Miller, B., Tenenholz, T., Egorin, M.J., Sosnovsky, G., Rao, N.U., Gutierrez, P.L. Cancer Lett. (1988)
- In vivo depletion of pancreatic acinar tissue simplifies islet preparation for transplantation. Al-Abdullah, I.H., Vulin, C.L., Kumar, M.S. Transplantation (1996)
- Fertilization following mixed insemination with 'cervix-selected' and 'unselected' spermatozoa in the rabbit. Fischer, B., Adams, C.E. J. Reprod. Fertil. (1981)
- Dosing of thioTEPA for myeloablative therapy. Przepiorka, D., Madden, T., Ippoliti, C., Estrov, Z., Dimopoulos, M. Cancer Chemother. Pharmacol. (1995)
- Simultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. de Jonge, M.E., van Dam, S.M., Hillebrand, M.J., Rosing, H., Huitema, A.D., Rodenhuis, S., Beijnen, J.H. Journal of mass spectrometry : JMS. (2004)
- Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy. Huitema, A.D., Mathôt, R.A., Tibben, M.M., Schellens, J.H., Rodenhuis, S., Beijnen, J.H. British journal of clinical pharmacology. (2001)
- High-performance liquid chromatography of the anti-tumour agent triethylenethiophosphoramide and its metabolite triethylenephosphoramide with sodium sulphide, taurine and o-phthalaldehyde as pre-column fluorescent derivatization reagents. Sano, A., Matsutani, S., Takitani, S. J. Chromatogr. (1988)
- Up-regulation of mucin secretion in HT29-MTX cells by the pro-inflammatory cytokines tumor necrosis factor-alpha and interleukin-6. Smirnova, M.G., Kiselev, S.L., Birchall, J.P., Pearson, J.P. Eur. Cytokine Netw. (2001)
- Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA. Jacobson, P.A., Green, K., Birnbaum, A., Remmel, R.P. Cancer Chemother. Pharmacol. (2002)
- Biotransformation of N,N',N''-triethylenethiophosphoramide: oxidative desulfuration to yield N,N',N''-triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic P-450 monooxygenase. Ng, S.F., Waxman, D.J. Cancer Res. (1990)
- Gas chromatographic analysis of triethylenethiophosphoramide and triethylenephosphoramide in biological specimens. McDermott, B.J., Double, J.A., Bibby, M.C., Wilman, D.E., Loadman, P.M., Turner, R.L. J. Chromatogr. (1985)
- Laparoscopic transperitoneal versus extraperitoneal inguinal hernia repair: a prospective clinical trial. Van Hee, R., Goverde, P., Hendrickx, L., Van der Schelling, G., Totté, E. Acta chirurgica Belgica. (1998)