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Chemical Compound Review

Terranas     1-[bis(4- fluorophenyl)methyl]-4- [(2,3,4...

Synonyms: Migsis, Lomerizine HCl, Terranas (TN), DE-090, AG-A-17849, ...
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Disease relevance of lomerizine

  • These results suggest that calcium influx into neurons participates in the pathogenesis of DND, and also that KB-2796 might prevent both morphological and functional cell damage in CA1 neurons induced by transient ischemia [1].
  • This study demonstrates that although MK-801 or KB-2796 does not prevent paraplegia due to spinal cord ischemia in the rabbit, both drugs can influence the rate of recovery after ischemic injury [2].
  • The protective effect of KB-2796 exceeds the effect of calcium blockers previously used in experimental spinal cord ischemia [3].
  • These results suggest that the protective effect of KB-2796 in cerebral hypoxia and ischemia is due in part to a mechanism independent of its effects as a cerebral vasodilator [4].
  • KB-2796 showed an apparent protective potency against complete ischemia induced by decapitation, normobaric hypoxia and KCN-induced death in mice [4].

High impact information on lomerizine


Biological context of lomerizine


Anatomical context of lomerizine


Associations of lomerizine with other chemical compounds

  • Intrarenal infusion of KB-2796 at 30 micrograms/kg/min and nicardipine at 0.3 microgram/kg/min produced a significant increase in GFR, RBF, UF, urinary excretion of electrolytes, and renin secretion rate [7].
  • According to the hypothesis that calcium antagonists can potentiate the analgesic effect of opioids, we designed a study to investigate the effects of KB-2796, a new calcium channel blocker, on the antinociception of fentanyl at the level of the spinal cord in rats [11].

Gene context of lomerizine


Analytical, diagnostic and therapeutic context of lomerizine


  1. Effects of a new calcium channel blocker, KB-2796, on protein synthesis of the CA1 pyramidal cell and delayed neuronal death following transient forebrain ischemia. Yoshidomi, M., Hayashi, T., Abe, K., Kogure, K. J. Neurochem. (1989) [Pubmed]
  2. Comparative effects of the N-methyl-D-aspartate antagonist MK-801 and the calcium channel blocker KB-2796 on neurologic and metabolic recovery after spinal cord ischemia. Danielisová, V., Chavko, M. Exp. Neurol. (1998) [Pubmed]
  3. KB-2796, a calcium channel blocker, ameliorates ischemic spinal cord damage in rabbits. Danielisova, V., Chavko, M. Neurochem. Res. (1994) [Pubmed]
  4. Protective effect of KB-2796, a new calcium antagonist, in cerebral hypoxia and ischemia. Hara, H., Ozaki, A., Yoshidomi, M., Sukamoto, T. Archives internationales de pharmacodynamie et de thérapie. (1990) [Pubmed]
  5. Differential vasorelaxant effects of K(+)-channel openers and Ca(2+)-channel blockers on canine isolated arteries. Iwamoto, T., Nishimura, N., Morita, T., Sukamoto, T. J. Pharm. Pharmacol. (1993) [Pubmed]
  6. Effects of KB-2796, a new calcium antagonist, and other diphenylpiperazines on [3H]nitrendipine binding. Iwamoto, T., Morita, T., Kanazawa, T., Ohtaka, H., Ito, K. Jpn. J. Pharmacol. (1988) [Pubmed]
  7. Effects of KB-2796, a new diphenylpiperazine calcium antagonist, on renal hemodynamics and urine formation in anesthetized dogs. Iwamoto, T., Morita, T., Sukamoto, T., Ito, K. Jpn. J. Pharmacol. (1992) [Pubmed]
  8. Effects of a new diphenylpiperazine calcium antagonist, KB-2796, on cerebral ischemic neuronal damage in rats. Yamashita, A., Ozaki, A., Ikegami, A., Hayashi, A., Hara, H., Sukamoto, T., Ito, K. Gen. Pharmacol. (1993) [Pubmed]
  9. Effects of a new Ca2+ antagonist, KB-2796, on the regional cerebral blood flow and somatosensory evoked potentials in the ischemic brain in cats. Harada, K., Nakasu, Y., Matsuda, M., Handa, J. Surgical neurology. (1988) [Pubmed]
  10. Calcium antagonism by KB-2796, a new diphenylpiperazine analogue, in dog vascular smooth muscle. Iwamoto, T., Morita, T., Sukamoto, T. J. Pharm. Pharmacol. (1991) [Pubmed]
  11. Enhancement of antinociceptive effect of fentanyl by KB-2796 at spinal level. Wong, J.O., Chang, C.L., Cheng, J.T. Acta Anaesthesiol. Sin. (1994) [Pubmed]
  12. The effects of KB-2796 and BAY K 8644 on fentanyl-induced analgesia in rats. Wong, J.O., Chang, C.L., Cheng, J.T. Acta Anaesthesiol. Sin. (1994) [Pubmed]
  13. Isolation and identification of the new metabolites of 1-[bis(4-fluorophenyl)-methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (KB-2796) from rat bile, urine and feces. Kawashima, T., Satomi, O., Awata, N. J. Pharmacobio-dyn. (1991) [Pubmed]
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