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MeSH Review

Hypoxia, Brain

 
 
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Disease relevance of Hypoxia, Brain

 

Psychiatry related information on Hypoxia, Brain

 

High impact information on Hypoxia, Brain

  • The release of glutamate during brain anoxia or ischaemia triggers the death of neurons, causing mental or physical handicap [8].
  • This stoichiometry predicts a minimum [Glu]o of 0.6 microM normally (tonically activating presynaptic autoreceptors and post-synaptic NMDA receptors), and 370 microM during brain anoxia (high enough to kill neurons) [9].
  • This will facilitate a rise in the extracellular glutamate concentration to neurotoxic levels and contribute to the neuronal death occurring in brain anoxia and ischaemia [10].
  • ODC activity and polyamine concentrations appear to be useful enzymatic markers for fetal brain hypoxia [11].
  • Prion protein accumulation and neuroprotection in hypoxic brain damage [12].
 

Chemical compound and disease context of Hypoxia, Brain

 

Biological context of Hypoxia, Brain

 

Anatomical context of Hypoxia, Brain

 

Gene context of Hypoxia, Brain

  • These data demonstrate the activation of the proangiogenic VEGF signaling cascade in patients with CM, probably reflecting compensatory mechanisms of general and focal brain hypoxia observed in these patients [28].
  • These observations suggest that the elevation of serum S100B may mainly be caused by leakage following massive brain damage due to injury and cerebral hypoxia/ischemia, and in part by systemic hypoxic/traumatic tissue damage, depending on the survival time [29].
  • Previous studies have demonstrated that brain hypoxia and ischaemia lead to the production of proinflammatory cytokines, including tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) and IL-6 [30].
  • In previous studies, we have shown that cerebral hypoxia results in increased activation of MAPK-1 and MAPK-3 [31].
  • Protection of striatal neurons by joint blockade of D1 and D2 receptor subtypes in an in vitro model of cerebral hypoxia [32].
 

Analytical, diagnostic and therapeutic context of Hypoxia, Brain

References

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