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Chemical Compound Review

Epontol     propyl2-[4- (diethylcarbamoylmethoxy)- 3...

Synonyms: Fabantol, Fabontal, Propantan, Sombrevin, Propanidid, ...
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Disease relevance of Propanidid

  • An adverse reaction to the intravenous anaesthetic agent propanidid is described in which the main features were hypotension, facial erythema, and abdominal pain [1].
  • Contact dermatitis due to propanidid in an anesthetist [2].
  • The depression of arterial pressure caused by propanidid is moderated by two compensatory mechanisms: normal barostatic reflexes causing an increased sympathetic tone in response to hypotension and a vagolytic action of propanidid [3].
  • A further dose of propanidid (1 mg/kg body weight) was administered 3 minutes after the initial injection of this drug, as a means of preventing maternal awareness during equilibration with the anaesthetic gas mixture [4].

High impact information on Propanidid

  • Unlike barbiturates, propanidid did not stimulate the binding of [3H]flunitrazepam to membranes [5].
  • Enhancement of [3H]muscimol binding was observed only in the presence of Cl- ions, half-maximal activation being achieved at approx. 40 mM-Cl-. Picrotoxinin inhibited the stimulation of [3H]muscimol binding by propanidid with an IC50 (concentration causing 50% inhibition) value of approx. 25 microM [5].
  • Propanidid (1 mM) exerted little effect on the affinity of muscimol binding (KD approx. 10 nM), but increased the apparent number of high-affinity binding sites in the membrane by 2-fold [5].
  • On the other hand, the general lipophilic anaesthetics, propanidid and althesin, led to an increase, by 70 and 32%, respectively, while the local anaesthetic, procaine, led to a decrease by 20%, in the fluidity of the erythrocyte membrane [6].
  • The two closely related enzymes that are responsible for the microsomal hydrolysis of palmitoyl-CoA and long chain monoacylglycerides exhibit the highest propanidid-and aspirin-cleaving rates [7].

Biological context of Propanidid


Anatomical context of Propanidid


Associations of Propanidid with other chemical compounds


Gene context of Propanidid


Analytical, diagnostic and therapeutic context of Propanidid


  1. Immune reaction to propanidid. Christmas, D. Anaesthesia. (1984) [Pubmed]
  2. Contact dermatitis due to propanidid in an anesthetist. Gastelain, P.Y., Piriou, A. Contact Derm. (1980) [Pubmed]
  3. The effects of propanidid on arterial pressure, pulse rate, preganglionic sympathetic activity and barostatic reflexes in the cat. Wisborg, K., Sapthavichaikul, S., Skovsted, P. Canadian Anaesthetists' Society journal. (1977) [Pubmed]
  4. Propanidid for anaesthetic induction at Caesarean section. Mahomedy, M.C., Downing, J.W., Jeal, D.E., Coleman, A.J. S. Afr. Med. J. (1975) [Pubmed]
  5. The gamma-aminobutyrate/benzodiazepine receptor from pig brain. Enhancement of gamma-aminobutyrate-receptor binding by the anaesthetic propanidid. Kirkness, E.F., Turner, A.J. Biochem. J. (1986) [Pubmed]
  6. Perturbation of the fluidity of the erythrocyte membrane with ionophoric antibiotics and lipophilic anaesthetics. Abu-Salah, K.M. Biochem. Pharmacol. (1991) [Pubmed]
  7. Hydrolysis of ester- and amide-type drugs by the purified isoenzymes of nonspecific carboxylesterase from rat liver. Mentlein, R., Heymann, E. Biochem. Pharmacol. (1984) [Pubmed]
  8. Prolongation of anesthetic action by BNPP (bis-[p-nitrophenyl] phosphate). Boyce, J.R., Wright, F.J., Cervenko, F.W., Pietak, S.P., Faulkner, S. Anesthesiology (1976) [Pubmed]
  9. Effect of the general anaesthetic propanidid on oxidative phosphorylation and calcium transport in rt liver mitochondria. Sweetman, A.J., Lovett, G.S., Markham, A., Cameron, I. Biochem. Pharmacol. (1981) [Pubmed]
  10. Reliability of the vestibulo-ocular reflex as an index of the effects of hypnotic drugs on the central nervous system. Cerchiari, E.L., Carugo, D., Della Puppa, T., Ravizza, A. British journal of anaesthesia. (1984) [Pubmed]
  11. Comparison of the immediate effects of etomidate, propanidid and thiopentone on haemodynamics, coronary bloodflow and myocardial oxygen consumption. Patschke, D., Brückner, J.B., Gethmann, J.W., Tarnow, J., Weymar, A. Acta anaesthesiologica Belgica. (1975) [Pubmed]
  12. The negative inotropic action of propanidid. influence on calcium movements in atrial tissue. Porsius, A.J., Van Zwieten, P.A. Eur. J. Pharmacol. (1975) [Pubmed]
  13. A method of anaesthesia for fractional coagulation of the Gasserian ganglion. Intermittent anaesthesia with propanidid. Fletcher, R. Anaesthesia. (1976) [Pubmed]
  14. Anaesthetic induction for Caesarean section with propanidid. Mahomedy, M.C., Downing, J.W., Jeal, D.E., Coleman, A.J. Anaesthesia. (1976) [Pubmed]
  15. Metabolic degradation of propanidid by various tissues. Short communication. Porsius, A.J., van Zwieten, P.A. Arzneimittel-Forschung. (1976) [Pubmed]
  16. Isolation of mast cells from rabbit lung and liver: comparison of histamine release induced by the hypnotics Althesin and propanidid. Ennis, M., Lorenz, W., Gerland, W., Heise, J. Agents Actions (1987) [Pubmed]
  17. In vitro interaction of propanidid and suxamethonium with pooled human plasma cholinesterase. A kinetic study. Taussig, P.E., Stojak, H.E., Bennett, N.R. British journal of anaesthesia. (1979) [Pubmed]
  18. Presynaptic effect of I.V. anaesthetic agents at the neuromuscular junction. Torda, T.A., Murphy, E.C. British journal of anaesthesia. (1979) [Pubmed]
  19. Plasma viscosity and cremophor-containing anaesthetics. Gramstad, L., Stovner, J. British journal of anaesthesia. (1979) [Pubmed]
  20. On the mechanism of the negative inotropic action of halothane and propanidide. Porsius, A.J., Van Zwieten, P.A. Recent advances in studies on cardiac structure and metabolism. (1975) [Pubmed]
  21. Effects of phenobarbital and p,p'-DDT on carboxylesterase activity and hydrolysis of propanidid in rat liver. Nousiainen, U. Gen. Pharmacol. (1985) [Pubmed]
  22. High-performance liquid chromatography of propanidid in rat plasma. Nousiainen, U., Raatikainen, O. J. Chromatogr. (1984) [Pubmed]
  23. Anaesthesia for cardioversion: a comparison of diazepam, thiopentone and propanidid. Orko, R. British journal of anaesthesia. (1976) [Pubmed]
  24. Treatment of malignant external otitis in its initial stage. Segal, S., Man, A. The American journal of otology. (1981) [Pubmed]
  25. Negative chronotropic effect of propanidid on the SA node of the dog heart in vivo. Nakajima, T., Yatabe, Y., Yagata, H. Archives internationales de pharmacodynamie et de thérapie. (1977) [Pubmed]
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