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Chemical Compound Review

Fenistil     N,N-dimethyl-2-[3-(1-pyridin- 2-ylethyl)-1H...

Synonyms: Foristal, Forhistal, Pecofenil, Fengel, Triten, ...
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Disease relevance of Dimetindene


Psychiatry related information on Dimetindene


High impact information on Dimetindene


Chemical compound and disease context of Dimetindene


Biological context of Dimetindene


Anatomical context of Dimetindene


Associations of Dimetindene with other chemical compounds

  • We conclude that dimethindene maleate is a moderately potent H1-receptor antagonist, and that the inhibition of the 48/80 and house dust mite induced weals is accounted for by the antihistaminic effect of dimethindene maleate [19].
  • The treated group of 20 patients was premedicated with the H1 antagonist dimetindene (0.2 mg/kg) and the H2 antagonist ranitidine (1.25 mg/kg); the control group of 20 patients received saline [20].
  • The concentration-response curve of histamine was shifted to the right by the H3 receptor antagonists thioperamide, impromidine and burimamide (apparent pA2 8.37, 6.86 and 7.05, respectively), by the H2 receptor antagonist ranitidine (apparent pA2 4.27) and was not affected by the H1 receptor antagonist dimetindene (32 mumols/l) [21].
  • Tissue oxygenation was ameliorated by the H1-antagonist treatment, as demonstrated by plasma lactate levels and base excess values (p < .05, control group versus dimethindene group) [22].
  • 12 h before a 4-h-lasting continuous challenge with permanent 1000 dactylis grass pollen in the VCC, administration of dimetindene (Fenistil R Pellets) in doses of 4 mg, 8 mg or identically appearing placebo was scheduled in three sessions [23].

Gene context of Dimetindene


Analytical, diagnostic and therapeutic context of Dimetindene


  1. Cutaneous responses to substance P and calcitonin gene-related peptide in chronic urticaria: the effect of cetirizine and dimethindene. Borici-Mazi, R., Kouridakis, S., Kontou-Fili, K. Allergy (1999) [Pubmed]
  2. Contact dermatitis from a gel containing dimethindene maleate. Valsecchi, R., di Landro, A., Pansera, B., Cainelli, T. Contact Derm. (1994) [Pubmed]
  3. Efficacy of topical dimetindene in experimentally induced pruritus and weal and flare reactions. Lever, L.R., Hill, S., Dykes, P.J., Marks, R. Skin Pharmacol. (1991) [Pubmed]
  4. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Uhl, W., Nolting, A., Golor, G., Rost, K.L., Kovar, A. Clinical toxicology (Philadelphia, Pa.) (2006) [Pubmed]
  5. Influence of H1- and H2-receptor antagonists on the circulatory system and on the endogenous plasma histamine concentrations in dogs. Thermann, M., Lorenz, W., Schmal, A., Schingale, F., Dormann, P., Hamelmann, H. Agents Actions (1977) [Pubmed]
  6. Effects of dimethindene maleate on psychomotor performance in the oculodynamic test compared with placebo and loratadine. Englisch, W., Rehn, D., Schaffler, K., Wauschkuhn, C.H. Arzneimittel-Forschung. (1996) [Pubmed]
  7. Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists. Böhme, T.M., Keim, C., Kreutzmann, K., Linder, M., Dingermann, T., Dannhardt, G., Mutschler, E., Lambrecht, G. J. Med. Chem. (2003) [Pubmed]
  8. Sedation and histamine H1-receptor antagonism: studies in man with the enantiomers of chlorpheniramine and dimethindene. Nicholson, A.N., Pascoe, P.A., Turner, C., Ganellin, C.R., Greengrass, P.M., Casy, A.F., Mercer, A.D. Br. J. Pharmacol. (1991) [Pubmed]
  9. Influence of the histaminergic system on opiate-induced neurosecretion and behaviour. Duka, T., Hoehe, M., Doenicke, A., Stephan, U., Matussek, N. Psychoneuroendocrinology (1987) [Pubmed]
  10. Novel histaprodifen analogues as potent histamine H1-receptor agonists in the pithed and in the anaesthetized rat. Schlicker, E., Kozłowska, H., Kwolek, G., Malinowska, B., Kramer, K., Pertz, H.H., Elz, S., Schunack, W. Naunyn Schmiedebergs Arch. Pharmacol. (2001) [Pubmed]
  11. Evaluation of the local anaesthetic activity of dimetindene maleate by means of laser algesimetry in healthy volunteers. Schaffler, K., Wauschkuhn, C.H., Brunnauer, H., Rehn, D. Arzneimittel-Forschung. (1992) [Pubmed]
  12. Evaluation of the local antihistaminic activity of dimetindene maleate by a quantitative method. Rampini, E., Oberhauser, V., Nunzi, E. Dermatologica (1978) [Pubmed]
  13. Action of dimethindene on the electrophysiological and mechanical properties of atrial and ventricular myocardium of guinea-pig. Mészáros, J., Szegi, J. Eur. J. Pharmacol. (1983) [Pubmed]
  14. Enantioselective biotransformation of the chiral antihistaminic drug dimethindene in humans and rats. Prien, D., Rehn, D., Blaschke, G. Arzneimittel-Forschung. (1997) [Pubmed]
  15. Pharmacokinetics of dimetindene after intravenous and oral administration to healthy volunteers. Arnera, V., Wermeille, M., Wellman, M., Llull, J.B., Althaus, M.A., Balant, L.P. Arzneimittel-Forschung. (1990) [Pubmed]
  16. Identification of the molecular structure of the phenolic primary metabolite of dimetindene in animals and man. De Graeve, J., Van Cantfort, J., Gilard, P., Wermeille, M.M. Arzneimittel-Forschung. (1989) [Pubmed]
  17. The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking. Noguchi, S., Inukai, T., Kuno, T., Tanaka, C. Physiol. Behav. (1992) [Pubmed]
  18. Effects of chloropyramine, dimethindene and diphenhydramine on transepithelial ion transport: studies in bovine tracheal epithelium and frog skin. Durand-Arczynska, W., Schoenenweid, F., Durand, J. J. Physiol. (Paris) (1986) [Pubmed]
  19. The effect of topical dimethindene maleate on weal reactions. Humphreys, F., Shuster, S. British journal of clinical pharmacology. (1987) [Pubmed]
  20. Are hypotension and rash after atracurium really caused by histamine release? Doenicke, A., Moss, J., Lorenz, W., Hoernecke, R., Gottardis, M. Anesth. Analg. (1994) [Pubmed]
  21. Inhibition of noradrenaline release in the rat brain cortex via presynaptic H3 receptors. Schlicker, E., Fink, K., Hinterthaner, M., Göthert, M. Naunyn Schmiedebergs Arch. Pharmacol. (1989) [Pubmed]
  22. Effect of H1-antagonism on cardiovascular, pulmonary, and immunological dysfunction in porcine endotoxic shock. Dimmeler, S., Lechleuthner, A., Auweiler, M., Troost, C., Nagelschmidt, M., Neugebauer, E. Shock (1995) [Pubmed]
  23. Pharmacodynamic dose finding of dimetindene in a sustained release formulation. Horak, F., Jäger, S., Nirnberger, G., Berger, U., Andresen, L., Vix, J.M., Rehn, D. Arzneimittel-Forschung. (1993) [Pubmed]
  24. The role of histamine H1 receptors in the thermoregulatory effect of morphine in mice. Ulugöl, A., Karadağ, H.C., Dökmeci, D., Baldik, Y., Dökmeci, I. Eur. J. Pharmacol. (1996) [Pubmed]
  25. Identification of endothelial H1, vascular H2 and cardiac presynaptic H3 receptors in the pithed rat. Malinowska, B., Schlicker, E. Naunyn Schmiedebergs Arch. Pharmacol. (1993) [Pubmed]
  26. Efficacy and safety of intranasally applied dimetindene maleate solution. Multicenter study in children under 14 years suffering from seasonal allergic rhinitis. Bauer, C.P., Unkauf, M. Arzneimittel-Forschung. (2001) [Pubmed]
  27. Enantioselective determination of dimethindene in urine after oral administration of racemic dimethindene. Radler, S., Blaschke, G. J. Chromatogr. (1991) [Pubmed]
  28. Mechanistic study of opposite migration order of dimethindene enantiomers in capillary electrophoresis in the presence of native beta-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin. Chankvetadze, B., Pintore, G., Burjanadze, N., Bergenthal, D., Bergander, K., Breitkreuz, J., Mühlenbrock, C., Blaschke, G. Journal of chromatography. A. (2000) [Pubmed]
  29. Dose-related control of allergic rhinitis symptoms by a H1-receptor antagonist. Finding the proper doses [correction of dosis] of dimethindene maleate in patients with allergic rhinitis. Horak, F.F., Jäger, S., Nirnberger, G., Berger, U., Andresen, I., Vix, J.M., Rehn, D. Int. Arch. Allergy Immunol. (1994) [Pubmed]
  30. Time course of the effect of intravenous dimetindene maleate. Rehn, D., Geissler, H., Schönbrunn, U., Lukas, H., Hennings, G. Eur. J. Clin. Pharmacol. (1990) [Pubmed]
  31. The determination of dimethindene in human serum by enzyme-linked immunosorbent assay (EIA). Wermeille, M., Moret, E., Siest, J.P., Ghribi, S., Petit, A.M., Wellman, M. Journal of pharmaceutical and biomedical analysis. (1993) [Pubmed]
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