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Chemical Compound Review

Dapriton     (3S)-3-(4-chlorophenyl)-N,N- dimethyl-3...

Synonyms: Destral, Fortamine, Isomerine, Polaramin, Trenelone, ...
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Disease relevance of Chlo-amine


Psychiatry related information on Chlo-amine


High impact information on Chlo-amine

  • Prednisolone, dexchlorpheniramine, and ranitidine were standard premedication [8].
  • The binding of 125I-iodobolpyramine to human T cells was reversible when using 1000-fold excess of the cold H1 antagonist, d-chlorpheniramine [9].
  • Two H1 antagonists, dexchlorpheniramine (10 mg, iv) and promethazine (50 mg, im), reduced PRL release in both sexes, stimulated LH release in men, and inhibited LH release in women [10].
  • In order to evaluate the possible role of endogenous histamine in the control of human growth hormone (hGH) secretion, we investigated the effect of two anti-histamine drugs, meclastine and dexchlorpheniramine, on the hGH response to arginine infusion and to insulin hypoglycemia in 30 normal subjects [1].
  • The results from activation study using visual discrimination tasks demonstrated that enhanced activity in the right prefrontal and anterior cingulate cortices as well as a decreased activity in the left temporal and frontal cortices and midbrain after the treatment of d-chlorpheniramine [11].

Chemical compound and disease context of Chlo-amine


Biological context of Chlo-amine

  • 3. DH in doses of 0.1, 1.0 and 10 mg kg(-1) and CP in doses of 0.01, 0.1 and 1.0 mg kg(-1) administered intravenously 15 min after the OA challenge partially reduced the UNDW-IB at 1 and 2 min after the UNDW inhalation in a dose-dependent manner [16].
  • Auditory event-related potentials (ERPs) were recorded in 20 healthy male humans, who received either a single 4 mg dose of d-chlorpheniramine or a placebo, according to a double-blind design [17].
  • Dexchlorpheniramine even enhanced the apomorphine-induced penile erections and induced penile erections in physostigmine-treated rats [18].
  • Amylin's inhibitory effect on food intake (i.e. 50% reduction in cumulative food intake 30 min after ingestion) was markedly reduced by CPA and PYR (e.g. amylin and CPA: 5% reduction versus control) [19].
  • The results showed that the amination at position 4 in fortamine occurred after formation of the pseudodisaccharide [20].

Anatomical context of Chlo-amine


Associations of Chlo-amine with other chemical compounds


Gene context of Chlo-amine

  • Promethazine, given concomitantly to an iv bolus injection of TRH (200 micrograms) (6 women) and d-chlorpheniramine, given at the onset of suckling (6 women), did not alter stimulation of PRL release induced by these challenges [30].
  • There were no changes in global CBF for the subjects treated with 2 mg d-chlorpheniramine (pre; 44.8+/-3.3 ml dl(-1) min(-1) vs post; 44.4+/-4.7 ml dl(-1) min(-1)) [11].
  • The regional blockade of H1R was observed mainly in the frontal, temporal and anterior cingulate cortices, and the intravenous administration of d-chlorpheniramine as a therapeutic dose (2 mg) blocked over 60% of H1R in the frontal cortices [11].
  • The safety and efficacy of loratadine was compared with that of dexchlorpheniramine in children with allergic rhinitis [4].
  • Addition of the H1-receptor antagonist, d-chlorpheniramine, to the perfusate completely inhibited basal histamine release from the IPL of both air- and O2-exposed rats, while addition of the H2-receptor antagonist, metamide, potentiated the release process [31].

Analytical, diagnostic and therapeutic context of Chlo-amine


  1. Effect of the antihistaminic agents meclastine and dexchlorpheniramine on the response of human growth hormone to arginine infusion and insulin hypoglycemia. Pontiroli, A.E., Viberti, G., Vicari, A., Pozza, G. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  2. Budesonide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in asthma and rhinitis. Clissold, S.P., Heel, R.C. Drugs (1984) [Pubmed]
  3. In vitro and in vivo antibacterial activity of KW1070, a new aminoglycoside antibiotic. Ohashi, Y., Kawabe, H., Sato, K., Nakamura, N., Kurashige, S., Mitsuhashi, S. Antimicrob. Agents Chemother. (1980) [Pubmed]
  4. Efficacy and safety of loratadine suspension in the treatment of children with allergic rhinitis. Boner, A.L., Miglioranzi, P., Richelli, C., Marchesi, E., Andreoli, A. Allergy (1989) [Pubmed]
  5. Modification of formalin-induced nociception by different histamine receptor agonists and antagonists. Farzin, D., Nosrati, F. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (2007) [Pubmed]
  6. Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance. Theunissen, E.L., Vermeeren, A., Ramaekers, J.G. British journal of clinical pharmacology. (2006) [Pubmed]
  7. Rodent antinociception following acute treatment with different histamine receptor agonists and antagonists. Farzin, D., Asghari, L., Nowrouzi, M. Pharmacol. Biochem. Behav. (2002) [Pubmed]
  8. Phase II trial of paclitaxel and carboplatin in metastatic small-cell lung cancer: a Groupe Français de Pneumo-Cancérologie study. Thomas, P., Castelnau, O., Paillotin, D., Léna, H., Robinet, G., Muir, J.F., Delaval, P., Gouva, S., Balmes, P., Blanchon, F., Perdu, D., Poirier, R., Pommier De Santi, P., Penot-Ragon, C., Kleisbauer, J.P. J. Clin. Oncol. (2001) [Pubmed]
  9. Characterization of histamine H1 binding sites on human T lymphocytes by means of 125I-iodobolpyramine. Preferential expression of H1 receptors on CD8 T lymphocytes. Villemain, F.M., Bach, J.F., Chatenoud, L.M. J. Immunol. (1990) [Pubmed]
  10. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. Pontiroli, A.E., De Castro e Silva, E., Mazzoleni, F., Alberetto, M., Baio, G., Pellicciotta, G., De Pasqua, A., Stella, L., Girardi, A.M., Pozza, G. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  11. Functional neuroimaging of cognition impaired by a classical antihistamine, d-chlorpheniramine. Okamura, N., Yanai, K., Higuchi, M., Sakai, J., Iwata, R., Ido, T., Sasaki, H., Watanabe, T., Itoh, M. Br. J. Pharmacol. (2000) [Pubmed]
  12. Comparative study of the efficacy, tolerance and side-effects of dexchlorpheniramine maleate 6 mg b.i.d. with terfenadine 60 mg b.i.d. Gutkowski, A., Del Carpio, J., Gelinas, B., Schulz, J., Turenne, Y. J. Int. Med. Res. (1985) [Pubmed]
  13. Two cases of cross-sensitivity in subjects allergic to paraphenylenediamine following ingestion of Polaronil. Sornin de Leysat, C., Boone, M., Blondeel, A., Song, M. Dermatology (Basel) (2003) [Pubmed]
  14. Mequitazine and dexchlorpheniramine in perennial rhinitis. A double-blind cross-over placebo-controlled study. Pukander, J.S., Karma, P.H., Penttilä, M.A., Perälä, M.E., Ylitalo, P., Kataja, M.J. Rhinology. (1990) [Pubmed]
  15. A slow release combined preparation (dexchlorpheniramine + pseudoephedrine) for symptomatic treatment of the common cold. Virtanen, H. The Journal of laryngology and otology. (1983) [Pubmed]
  16. A partial involvement of histamine in ultrasonically nebulized distilled water-induced bronchoconstriction in guinea-pigs. Fujimura, M., Amemiya, T., Myou, S., Ishiura, Y., Sasaki, S., Matsuda, T. Br. J. Pharmacol. (1998) [Pubmed]
  17. The H1-receptor antagonist chlorpheniramine decreases the ending phase of the mismatch negativity of the human auditory event-related potentials. Serra, J.M., Escera, C., Sánchez-Turet, M., Sánchez-Sastre, J., Grau, C. Neurosci. Lett. (1996) [Pubmed]
  18. Antagonism of drug-induced yawning and penile erections in rats. Gower, A.J., Berendsen, H.H., Broekkamp, C.L. Eur. J. Pharmacol. (1986) [Pubmed]
  19. Histamine H1 receptors in the ventromedial hypothalamus mediate the anorectic action of the pancreatic hormone amylin. Mollet, A., Meier, S., Riediger, T., Lutz, T.A. Peptides (2003) [Pubmed]
  20. Biosynthesis of astromicin and related antibiotics. II. Biosynthetic studies with blocked mutants of Micromonospora olivasterospora. Odakura, Y., Kase, H., Itoh, S., Satoh, S., Takasawa, S., Takahashi, K., Shirahata, K., Nakayama, K. J. Antibiot. (1984) [Pubmed]
  21. Receptor-independent G protein activation may account for the stimulatory effects of first-generation H1-receptor antagonists in HL-60 cells, basophils, and mast cells. Burde, R., Dippel, E., Seifert, R. Biochem. Pharmacol. (1996) [Pubmed]
  22. Comparison of intra-accumbens injection of histamine with histamine H1-receptor antagonist chlorpheniramine in effects on reinforcement and memory parameters. Hasenöhrl, R.U., Kuhlen, A., Frisch, C., Galosi, R., Brãndao, M.L., Huston, J.P. Behav. Brain Res. (2001) [Pubmed]
  23. Effects of 5HT uptake inhibitors on the pressor response to 5HT in the pithed rat. The significance of the 5HT blocking property. Petersen, E.N., Olsson, S.O., Squires, R.F. Eur. J. Pharmacol. (1977) [Pubmed]
  24. Attenuation of cutaneous reactivity to histamine by cetirizine and dexchlorpheniramine. Müller, F.O., Botha, J.J., van Dyk, M., Luus, H.G., Groenewoud, G. Eur. J. Clin. Pharmacol. (1988) [Pubmed]
  25. Receptor effects of cetirizine. Snyder, S.H., Snowman, A.M. Annals of allergy. (1987) [Pubmed]
  26. Development of a validated capillary electrophoresis method for enantiomeric purity testing of dexchlorpheniramine maleate. Van Eeckhaut, A., Detaevernier, M.R., Michotte, Y. Journal of chromatography. A. (2002) [Pubmed]
  27. Histamine H1 receptors in human brain visualized in vivo by [11C]doxepin and positron emission tomography. Yanai, K., Watanabe, T., Yokoyama, H., Meguro, K., Hatazawa, J., Itoh, M., Iwata, R., Ishiwata, K., Takahashi, T., Ido, T. Neurosci. Lett. (1992) [Pubmed]
  28. Localized expression of histamine h(1) receptors in syncytiotrophoblast cells of human placenta. Matsuyama, K., Ichikawa, T., Nitta, Y., Ikoma, Y., Ishimura, K., Horio, S., Fukui, H. J. Pharmacol. Sci. (2006) [Pubmed]
  29. Treatment of seasonal allergic rhinitis--a double blind, group comparative study of terfenadine and dexchlorpheniramine. Johansen, L.V., Bjerrum, P., Illum, P. Rhinology. (1987) [Pubmed]
  30. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. Messinis, I.E., Souvatzoglou, A., Fais, N., Lolis, D. J. Endocrinol. Invest. (1985) [Pubmed]
  31. The effect of in vivo hyperoxic exposure on the release of endogenous histamine from the rat isolated perfused lung. Januszkiewicz, A.J., Faiman, M.D. Toxicol. Appl. Pharmacol. (1984) [Pubmed]
  32. A dose-ranging study of the effects of mequitazine on actual driving, memory and psychomotor performance as compared to dexchlorpheniramine, cetirizine and placebo. Theunissen, E.L., Vermeeren, A., van Oers, A.C., van Maris, I., Ramaekers, J.G. Clin. Exp. Allergy (2004) [Pubmed]
  33. Effect of the H1 blocker d-chlorpheniramine on cerebral blood flow in the conscious dog during normocapnic hypoxia. Audibert, G., Siat, J., Müller, C., Hartemann, D., Naja, G., Saunier, C.G., Laxenaire, M.C. Clinical physiology (Oxford, England) (1998) [Pubmed]
  34. The effects of a sedative antihistamine, d-chlorpheniramine, on visuomotor spatial discrimination and regional brain activity as measured by positron emission tomography (PET). Mochizuki, H., Tashiro, M., Tagawa, M., Kano, M., Itoh, M., Okamura, N., Watanabe, T., Yanai, K. Human psychopharmacology. (2002) [Pubmed]
  35. Postoperative intramuscular dextromethorphan injection provides postoperative pain relief and decreases opioid requirement after hemorrhoidectomy. Chang, F.L., Wu, C.T., Yeh, C.C., Lin, T.C., Ho, S.T., Wong, C.S. Acta Anaesthesiol. Sin. (1999) [Pubmed]
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