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Chemical Compound Review

Delursan     (4R)-4-[ (3R,5S,7S,8S,9S,10S,13R,14S,17 R)-3...

Synonyms: Destolit, Ursochol, Ursofalk, Ursolvan, ursodiol, ...
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Disease relevance of Ursolvan


High impact information on Ursolvan


Chemical compound and disease context of Ursolvan


Biological context of Ursolvan


Anatomical context of Ursolvan


Associations of Ursolvan with other chemical compounds

  • While there is effective treatment for AIH (steroids with or without azathioprine) and PBC (Ursodesoxycholic acid) no such treatment is currently established for PSC [19].
  • In conclusion, administration for 2 wk of TUDCA, compared with an equimolar amount of unconjugated UDCA plus taurine, produced in the bile of hamsters a higher percentage of UDCA, a lower glycine-to-taurine ratio of UDCA conjugates, and a lower saturation index before and after adjustment for UDCA-rich bile [20].

Gene context of Ursolvan


Analytical, diagnostic and therapeutic context of Ursolvan


  1. Effect of beta-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J mice. Wang, D.Q., Tazuma, S. J. Lipid Res. (2002) [Pubmed]
  2. Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver. Kurz, A.K., Block, C., Graf, D., Dahl, S.V., Schliess, F., Häussinger, D. Biochem. J. (2000) [Pubmed]
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  4. Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration. Del Puppo, M., Galli Kienle, M., Crosignani, A., Petroni, M.L., Amati, B., Zuin, M., Podda, M. J. Lipid Res. (2001) [Pubmed]
  5. Ursodesoxycholic acid: effect on xanthomas in Alagille-Watson syndrome. Krawinkel, M.B., Santer, R., Oldigs, H.D. J. Pediatr. Gastroenterol. Nutr. (1994) [Pubmed]
  6. Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: a population-based cohort study. Jackson, H., Solaymani-Dodaran, M., Card, T.R., Aithal, G.P., Logan, R., West, J. Hepatology (2007) [Pubmed]
  7. Bioequivalence of a new liquid formulation of ursodeoxycholic acid (Ursofalk suspension) and Ursofalk capsules measured by plasma pharmacokinetics and biliary enrichment. Setchell, K.D., Galzigna, L., O'Connell, N., Brunetti, G., Tauschel, H.D. Aliment. Pharmacol. Ther. (2005) [Pubmed]
  8. Bioavailability of four ursodeoxycholic acid preparations. Williams, C.N., Al-Knawy, B., Blanchard, W. Aliment. Pharmacol. Ther. (2000) [Pubmed]
  9. Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy. Reyes, H., Sjövall, J. Ann. Med. (2000) [Pubmed]
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  11. Studies on N-nitroso bile acid amides in relation to their possible role in gastrointestinal cancer. Dayal, B., Ertel, N.H. Lipids (1997) [Pubmed]
  12. Survival of patient with late onset hepatic failure by living-related liver transplantation from maternal donor with incompatible blood type. Kojima, A., Takagi, H., Abe, T., Sakurai, S., Sohara, N., Kakizaki, S., Nagamine, T., Mori, M., Matsunami, H., Ikegami, T., Hashikura, Y., Kawasaki, S., Makuuchi, M., Matsunami, M. J. Gastroenterol. (1998) [Pubmed]
  13. Effect of intraduodenal administration of 23-methyl-UDCA diastereoisomers on bile flow in hamsters. Clerici, C., Dozzini, G., Distrutti, E., Gentili, G., Sadeghpour, B.M., Natalini, B., Pellicciari, R., Rizzoli, R., Roda, A., Pelli, M.A. Dig. Dis. Sci. (1992) [Pubmed]
  14. Liver regeneration enhanced by orally administered ursodesoxycholic acid is mediated by immunosuppression in partially hepatectomized rats. Liu, L., Sakaguchi, T., Cui, X., Shirai, Y., Nishimaki, T., Hatakeyama, K. Am. J. Chin. Med. (2002) [Pubmed]
  15. Tamoxifen: a novel treatment for primary biliary cirrhosis? Reddy, A., Prince, M., James, O.F., Jain, S., Bassendine, M.F. Liver Int. (2004) [Pubmed]
  16. Hepatic branch vagotomy can block liver regeneration enhanced by ursodesoxycholic acid in 66% hepatectomized rats. Sakaguchi, T., Liu, L. Autonomic neuroscience : basic & clinical. (2002) [Pubmed]
  17. Regulation of taurocholate and ursodeoxycholate uptake in hamster hepatocytes by Ca(2+)-mobilizing agents. Bouscarel, B., Reza, S., Dougherty, L.A., Fromm, H., Nussbaum, R. Am. J. Physiol. (1996) [Pubmed]
  18. Orally administered gallbladder therapeutic agents, Part II: Actigall (ursodeoxycholic Acid, UDCA). Claussen, D.W. Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates. (1993) [Pubmed]
  19. Liver transplantation in autoimmune liver disease--selection of patients. Tillmann, H.L., Jäckel, E., Manns, M.P. Hepatogastroenterology (1999) [Pubmed]
  20. Enrichment of bile with tauroursodeoxycholic acid and biliary cholesterol saturation in hamsters. Handelsman, B., Bonorris, G., Marks, J.W., Schoenfield, L.J. Am. J. Physiol. (1982) [Pubmed]
  21. Effect of glutathione depletion and hydrophilic bile acids on hepatic acute phase reaction in rats with extrahepatic cholestasis. Roeb, E., Purucker, E., Gartung, C., Geier, A., Jansen, B., Winograd, R., Matern, S. Scand. J. Gastroenterol. (2003) [Pubmed]
  22. Hepatitis C virus infection with peripheral neuropathy is not always associated with cryoglobulinaemia. Lidove, O., Cacoub, P., Maisonobe, T., Servan, J., Thibault, V., Piette, J.C., Léger, J.M. Ann. Rheum. Dis. (2001) [Pubmed]
  23. Long-term evaluation of extracorporeal shock-wave lithotripsy for cholesterol gallstones. Tsumita, R., Sugiura, N., Abe, A., Ebara, M., Saisho, H., Tsuchiya, Y. J. Gastroenterol. Hepatol. (2001) [Pubmed]
  24. Improvement of ursodeoxycholic acid bioavailability by 2-hydroxypropyl-beta-cyclodextrin complexation in healthy volunteers. Panini, R., Vandelli, M.A., Forni, F., Pradelli, J.M., Salvioli, G. Pharmacol. Res. (1995) [Pubmed]
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