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MeSH Review

Bundle-Branch Block

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Disease relevance of Bundle-Branch Block


High impact information on Bundle-Branch Block


Chemical compound and disease context of Bundle-Branch Block


Biological context of Bundle-Branch Block


Anatomical context of Bundle-Branch Block


Gene context of Bundle-Branch Block

  • Brugada syndrome, an autosomal dominantly inherited form of ventricular fibrillation characterized by ST-segment elevation in leads V1-V3 and right bundle-branch block on surface electrocardiogram, is caused by mutations in the cardiac sodium channel gene SCN5A [25].
  • METHODS: The North American population with acute MI and bundle branch block enrolled in the Global Utilization of Streptokinase and t-PA [tissue-type plasminogen activator] for Occluded Coronary Arteries (GUSTO-I) trial was matched by age and Killip class with an equal number of GUSTO-I patients without conduction defects [2].
  • CONCLUSIONS: Our data show that (1) in mice, a continuity exists between the common bundle and the septum, and (2) Cx40 deficiency results in right bundle-branch block and impaired left bundle-branch conduction [26].
  • The RPEP/RVET could not be used to assess PA pressure in six patients with congestive cardiomyopathy nor in 18 patients with complete right bundle branch block (CRBBB) [27].
  • Magnetic measurement of S-T and T-Q segment shifts in humans. Part I: Early repolarization and left bundle branch block [28].

Analytical, diagnostic and therapeutic context of Bundle-Branch Block


  1. Radiofrequency catheter ablation of idiopathic left ventricular tachycardia guided by a Purkinje potential. Nakagawa, H., Beckman, K.J., McClelland, J.H., Wang, X., Arruda, M., Santoro, I., Hazlitt, H.A., Abdalla, I., Singh, A., Gossinger, H. Circulation (1993) [Pubmed]
  2. Acute myocardial infarction and complete bundle branch block at hospital admission: clinical characteristics and outcome in the thrombolytic era. GUSTO-I Investigators. Global Utilization of Streptokinase and t-PA [tissue-type plasminogen activator] for Occluded Coronary Arteries. Sgarbossa, E.B., Pinski, S.L., Topol, E.J., Califf, R.M., Barbagelata, A., Goodman, S.G., Gates, K.B., Granger, C.B., Miller, D.P., Underwood, D.A., Wagner, G.S. J. Am. Coll. Cardiol. (1998) [Pubmed]
  3. Cardiac conduction abnormalities in Reiter's syndrome. Ruppert, G.B., Lindsay, J., Barth, W.F. Am. J. Med. (1982) [Pubmed]
  4. Lower diagnostic accuracy of thallium-201 SPECT myocardial perfusion imaging in women: an effect of smaller chamber size. Hansen, C.L., Crabbe, D., Rubin, S. J. Am. Coll. Cardiol. (1996) [Pubmed]
  5. Gender differences in advanced heart failure: insights from the BEST study. Ghali, J.K., Krause-Steinrauf, H.J., Adams, K.F., Khan, S.S., Rosenberg, Y.D., Yancy, C.W., Young, J.B., Goldman, S., Peberdy, M.A., Lindenfeld, J. J. Am. Coll. Cardiol. (2003) [Pubmed]
  6. Disopyramide and bundle-branch block. Timins, B.I. Ann. Intern. Med. (1982) [Pubmed]
  7. Prognostic value of vasodilator myocardial perfusion imaging in patients with left bundle-branch block. Wagdy, H.M., Hodge, D., Christian, T.F., Miller, T.D., Gibbons, R.J. Circulation (1998) [Pubmed]
  8. Incidence and clinical relevance of the occurrence of bundle-branch block in patients treated with thrombolytic therapy. Newby, K.H., Pisanó, E., Krucoff, M.W., Green, C., Natale, A. Circulation (1996) [Pubmed]
  9. Long-term results of dual-chamber (DDD) pacing in obstructive hypertrophic cardiomyopathy. Evidence for progressive symptomatic and hemodynamic improvement and reduction of left ventricular hypertrophy. Fananapazir, L., Epstein, N.D., Curiel, R.V., Panza, J.A., Tripodi, D., McAreavey, D. Circulation (1994) [Pubmed]
  10. Regional myocardial perfusion and glucose metabolism in experimental left bundle branch block. Ono, S., Nohara, R., Kambara, H., Okuda, K., Kawai, C. Circulation (1992) [Pubmed]
  11. Effects of isoproterenol on bradycardia-dependent intra-His and left bundle branch blocks. Suárez, L.D., Kretz, A., Alvarez, J.A., Martinez, J.M., Perosio, A.M. Circulation (1981) [Pubmed]
  12. A clinical and follow-up study of right and left bundle branch block. Rotman, M., Triebwasser, J.H. Circulation (1975) [Pubmed]
  13. A new approach to the assessment of tomographic thallium-201 scintigraphy in patients with left bundle branch block. Matzer, L., Kiat, H., Friedman, J.D., Van Train, K., Maddahi, J., Berman, D.S. J. Am. Coll. Cardiol. (1991) [Pubmed]
  14. Adenosine-sensitive ventricular tachycardia from the anterobasal left ventricle. Yeh, S.J., Wen, M.S., Wang, C.C., Lin, F.C., Wu, D. J. Am. Coll. Cardiol. (1997) [Pubmed]
  15. Contrasting effects of verapamil and procainamide on rate-dependent bundle branch block: pharmacologic evidence for the role of depressed sodium channel responses. Chiale, P.A., Pastori, J.D., Sánchez, R.A., Elizari, M.V., Rosenbaum, M.B. J. Am. Coll. Cardiol. (1990) [Pubmed]
  16. Biventricular pacing with coronary bypass and Dor's ventriculoplasty. Mizuno, T., Tanaka, H., Makita, S., Tabuchi, N., Arai, H., Sunamori, M. Ann. Thorac. Surg. (2003) [Pubmed]
  17. Global and regional myocardial oxygen consumption and blood flow in severe cardiomyopathy with left bundle branch block. Lindner, O., Vogt, J., Baller, D., Kammeier, A., Wielepp, P., Holzinger, J., Lamp, B., Horstkotte, D., Burchert, W. Eur. J. Heart Fail. (2005) [Pubmed]
  18. Effects of cardiac resynchronization therapy on myocardial blood flow measured by oxygen-15 water positron emission tomography in idiopathic-dilated cardiomyopathy and left bundle branch block. Nowak, B., Stellbrink, C., Sinha, A.M., Kaiser, H.J., Reinartz, P., Koos, R., Markus, K., Hanrath, P., Buell, U., Schaefer, W.M. Am. J. Cardiol. (2004) [Pubmed]
  19. Right bundle branch block: a source of error in the Doppler assessment of right ventricular pressure in patients with a ventricular septal defect. Warren, A.E., Sharratt, G.P. The Canadian journal of cardiology. (1998) [Pubmed]
  20. Clinical and molecular heterogeneity in the Brugada syndrome: a novel gene locus on chromosome 3. Weiss, R., Barmada, M.M., Nguyen, T., Seibel, J.S., Cavlovich, D., Kornblit, C.A., Angelilli, A., Villanueva, F., McNamara, D.M., London, B. Circulation (2002) [Pubmed]
  21. VACTERL manifestations in two generations of a family. Nezarati, M.M., McLeod, D.R. Am. J. Med. Genet. (1999) [Pubmed]
  22. Electrical instability in patients undergoing surgery for atrioventricular septal defect. Daliento, L., Rizzoli, G., Marchiori, M.C., Buja, G., Milanesi, O., Valente, S., Stellin, G., Mazzucco, A. International journal of cardiology. (1991) [Pubmed]
  23. Congenital tricuspid valve stenosis with atrial septal defect and left anterior fascicular block. Cohen, M.L., Spray, T., Gutierrez, F., Barzilai, B., Bauwens, D. Clinical cardiology. (1990) [Pubmed]
  24. Partial dehiscence of a porcine prosthesis in association with aortic annular separation producing a false aneurysm of the ascending aorta. Come, P.C., Carl, L.V., Leeman, D., Abelmann, W.H., Weintraub, R.M. Catheterization and cardiovascular diagnosis. (1987) [Pubmed]
  25. Novel mutations in domain I of SCN5A cause Brugada syndrome. Vatta, M., Dumaine, R., Antzelevitch, C., Brugada, R., Li, H., Bowles, N.E., Nademanee, K., Brugada, J., Brugada, P., Towbin, J.A. Mol. Genet. Metab. (2002) [Pubmed]
  26. Impaired conduction in the bundle branches of mouse hearts lacking the gap junction protein connexin40. van Rijen, H.V., van Veen, T.A., van Kempen, M.J., Wilms-Schopman, F.J., Potse, M., Krueger, O., Willecke, K., Opthof, T., Jongsma, H.J., de Bakker, J.M. Circulation (2001) [Pubmed]
  27. Assessment of the pulmonary vascular bed by echocardiographic right ventricular systolic time intervals. Riggs, T., Hirschfeld, S., Borkat, G., Knoke, J., Liebman, J. Circulation (1978) [Pubmed]
  28. Magnetic measurement of S-T and T-Q segment shifts in humans. Part I: Early repolarization and left bundle branch block. Savard, P., Cohen, D., Lepeschkin, E., Cuffin, B.N., Madias, J.E. Circ. Res. (1983) [Pubmed]
  29. Adenosine thallium-201 is superior to exercise thallium-201 for detecting coronary artery disease in patients with left bundle branch block. O'Keefe, J.H., Bateman, T.M., Barnhart, C.S. J. Am. Coll. Cardiol. (1993) [Pubmed]
  30. Prognostic value of pharmacologic stress echocardiography in patients with left bundle branch block. Cortigiani, L., Picano, E., Vigna, C., Lattanzi, F., Coletta, C., Mariotti, E., Bigi, R. Am. J. Med. (2001) [Pubmed]
  31. New bundle branch block after coronary artery bypass grafting--evaluation by CK-MB isoenzyme analysis and transoesophageal echocardiography. Hake, U., Iversen, S., Erbel, R., Drexler, M., Neufang, A., Meyer, J., Oelert, H. Eur. Heart J. (1990) [Pubmed]
  32. Relation between exercise-induced myocardial ischemia as assessed by nitrogen-13 ammonia positron emission tomography and QT interval behavior in patients with right bundle branch block. Watanabe, T., Harumi, K., Akutsu, Y., Yamanaka, H., Michihata, T., Okazaki, O., Katagiri, T. Am. J. Cardiol. (1998) [Pubmed]
  33. Prediction of the effectiveness of long-term beta blocker treatment for dilated cardiomyopathy by signal averaged electrocardiography. Yamada, T., Fukunami, M., Shimonagata, T., Kumagai, K., Kim, J., Sanada, S., Ogita, H., Hori, M., Hoki, N. Heart (1998) [Pubmed]
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