Disease relevance of C06468

• Urticaria induced by D-psicose [1].
• Characterization of an Agrobacterium tumefaciens D-psicose 3-epimerase that converts D-fructose to D-psicose [2].
• Body weight gain and food intake were more extensively suppressed by the higher D-psicose diets [3].
• Cecal hypertrophy was observed in rats fed 10-40% D-psicose diets [4].
• Hence, D-psicose might be useful in preventing postprandial hyperglycemia in diabetic patients [5].

High impact information on C06468

• The turnover number (k(cat)) and catalytic efficiency (k(cat)/Km) of the enzyme for D-psicose were markedly higher than those for d-tagatose, suggesting that the enzyme is not D-tagatose 3-epimerase but D-psicose 3-epimerase [2].
• Therefore, we firstly examined the effect of rare sugars including D-psicose, D-allose, D-altrose and D-talitol on cell proliferation using certain cell lines in vitro [6].
• Efficient biosynthesis of D-allose from D-psicose by cross-linked recombinant L-rhamnose isomerase: separation of product by ethanol crystallization [7].
• These results suggest that supplemental D-psicose can lower plasma glucose levels and reduce body fat accumulation [5].
• D-allose, one of the rare sugars produced from D-psicose, has been shown to be effective against reperfusion injury after ischemia and partial hepatectomy in cirrhotic rat liver by improving remnant liver blood flow and survival rates, and decreasing liver enzyme levels and liver tissue injury levels [8].

Chemical compound and disease context of C06468

• Therefore, these results suggest that D-psicose may play a potential role as a neuroprotective agent in the treatment of neurodegenerative diseases by inducing an up-regulation of intracellular glutathione [9].
• Neuroprotective effect of D-psicose on 6-hydroxydopamine-induced apoptosis in rat pheochromocytoma (PC12) cells [9].

Biological context of C06468

• Metabolic effects of D-psicose in rats: studies on faecal and urinary excretion and caecal fermentation [10].
• We have previously reported that D-psicose supplements in diets suppressed hepatic lipogenic enzyme activity The lower fat accumulation in rats fed D-psicose may be due to lower lipogenesis in the liver [11].
• The results showed that D-psicose at a concentration of 50 mM, exerted significant protective effects against the 6-OHDA (200 muM)-induced PC12 cell apoptosis, while other sugars had little or no protective effects [9].

Anatomical context of C06468

• The weights of heart, spleen and abdominal adipose tissue were smaller in the order of dietary D-psicose concentration [4].
• These results suggest that D-psicose is partly absorbable in the digestive tract and is excreted into urine and faeces [10].
• Serum D-psicose concentration and D-psicose in the contents of stomach and small intestines decreased progressively after administration [10].

Associations of C06468 with other chemical compounds

• Abdominal adipose tissue weight was significantly lower (P < 0.05) in rats fed the D-psicose diet than in rats fed a D-fructose and D-glucose diets, even though the four dietary groups were offered the same amount throughout the experimental period [12].
• The effect of the rare sugar D-psicose on chitosan production by Rhizopus oryzae was studied [13].

Gene context of C06468

• Fatty acid synthase and glucose 6-phosphate dehydrogenase activities in the liver were significantly lower (P < 0.05) in rats fed the D-psicose diet than in rats fed the D-fructose and D-glucose diets [12].

Analytical, diagnostic and therapeutic context of C06468

• Urinary and faecal excretions of D-psicose over the 24 h, following a single oral administration, were 11-15% of dosage for the former and 8-13% of dosage for the latter [10].
• Empirically, approximately 338 g, that is, 90% of a theoretical overall yield for the purification of pure D-allose crystals was produced from 1.5 kg of D-psicose within 30 d using a constructed bioreactor [7].
• Each group except for the control group was fed a diet of 5% D-fructose, D-psicose, or psico-rare sugar (3:1 mixture of D-fructose and D-psicose) for 8 weeks [5].

References