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Chemical Compound Review

lyxo-Hexulose     (3S,4S,5R)-2- (hydroxymethyl)oxane- 2,3,4,5...

Synonyms: SureCN152959, CHEBI:4249, bmse000023, bmse000865, bmse000883, ...
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Disease relevance of lyxo-Hexulose


High impact information on lyxo-Hexulose


Chemical compound and disease context of lyxo-Hexulose


Biological context of lyxo-Hexulose

  • Gluconeogenesis from D-tagatose by isolated rat and hamster liver cells [12].
  • In a double-blind and balanced cross-over design, we measured 24-h energy expenditure in eight normal weight humans in a respiration chamber during the consumption of 30 g D-tagatose or 30 g sucrose/d. Metabolic measurements were performed before and after a 2-wk adaptation period with a 30-g daily intake of the test sugar [13].
  • All substrate-induced energy losses from D-tagatose, with sucrose as reference standard, were determined as a single value accounting for the sum of the energy losses to feces, urine, gaseous hydrogen and methane and substrate-induced thermogenesis [2].
  • To further explore the underlying mechanisms of cytoprotection, we investigated the effects of D-tagatose on both the generation of superoxide anion radicals and the consequences of oxidative stress driven by prooxidant compounds in intact cells [4].
  • D-tagatose was not found to increase the number of revertants per plate relative to vehicle controls in either the S. typhimurium tester strains or the WP2uvrA- tester strain with or without metabolic activation at doses up to 5000 microg/plate [14].

Anatomical context of lyxo-Hexulose


Associations of lyxo-Hexulose with other chemical compounds


Gene context of lyxo-Hexulose


Analytical, diagnostic and therapeutic context of lyxo-Hexulose


  1. Lactose and D-galactose metabolism in Staphylococcus aureus. IV. Isolation and properties of a class I D-ketohexose-1,6-diphosphate aldolase that catalyzes the cleavage of D-tagatose 1,6-diphosphate. Bissett, D.L., Anderson, R.L. J. Biol. Chem. (1980) [Pubmed]
  2. D-tagatose is a bulk sweetener with zero energy determined in rats. Livesey, G., Brown, J.C. J. Nutr. (1996) [Pubmed]
  3. Plasmid linkage of the D-tagatose 6-phosphate pathway in Streptococcus lactis: effect on lactose and galactose metabolism. Crow, V.L., Davey, G.P., Pearce, L.E., Thomas, T.D. J. Bacteriol. (1983) [Pubmed]
  4. Antioxidant and cytoprotective properties of D-tagatose in cultured murine hepatocytes. Paterna, J.C., Boess, F., Stäubli, A., Boelsterli, U.A. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
  5. 90-Day oral toxicity study of D-tagatose in rats. Kruger, C.L., Whittaker, M.H., Frankos, V.H., Trimmer, G.W. Regulatory toxicology and pharmacology : RTP. (1999) [Pubmed]
  6. Lactose and D-galactose metabolism in Staphylococcus aureus. II. Isomerization of D-galactose 6-phosphate to D-tagatose 6-phosphate by a specific D-galactose-6-phosphate isomerase. Bissett, D.L., Wenger, W.C., Anderson, R.L. J. Biol. Chem. (1980) [Pubmed]
  7. Lactose and D-galactose metabolism in Staphylococcus aureus. III. Purification and properties of D-tagatose-6-phosphate kinase. Bissett, D.L., Anderson, R.L. J. Biol. Chem. (1980) [Pubmed]
  8. In vitro fermentation pattern of D-tagatose is affected by adaptation of the microbiota from the gastrointestinal tract of pigs. Laerke, H.N., Jensen, B.B., Højsgaard, S. J. Nutr. (2000) [Pubmed]
  9. L-Sorbose but not D-tagatose induces hemolysis of dog erythrocytes in vitro. Bär, A., Leeman, W.R. Regulatory toxicology and pharmacology : RTP. (1999) [Pubmed]
  10. A novel enzymatic approach to the massproduction of L-galactose from L-sorbose. Leang, K., Maekawa, K., Menavuvu, B.T., Morimoto, K., Granström, T.B., Takada, G., Izumori, K. J. Biosci. Bioeng. (2004) [Pubmed]
  11. The genes and enzymes for the catabolism of galactitol, D-tagatose, and related carbohydrates in Klebsiella oxytoca M5a1 and other enteric bacteria display convergent evolution. Shakeri-Garakani, A., Brinkkötter, A., Schmid, K., Turgut, S., Lengeler, J.W. Mol. Genet. Genomics (2004) [Pubmed]
  12. Gluconeogenesis from D-tagatose by isolated rat and hamster liver cells. Rognstad, R. FEBS Lett. (1975) [Pubmed]
  13. D-Tagatose, a stereoisomer of D-fructose, increases hydrogen production in humans without affecting 24-hour energy expenditure or respiratory exchange ratio. Buemann, B., Toubro, S., Astrup, A. J. Nutr. (1998) [Pubmed]
  14. Genotoxicity tests on D-tagatose. Kruger, C.L., Whittaker, M.H., Frankos, V.H. Regulatory toxicology and pharmacology : RTP. (1999) [Pubmed]
  15. D-tagatose has low small intestinal digestibility but high large intestinal fermentability in pigs. Laerke, H.N., Jensen, B.B. J. Nutr. (1999) [Pubmed]
  16. Crystal structure of Escherichia coli L-arabinose isomerase (ECAI), the putative target of biological tagatose production. Manjasetty, B.A., Chance, M.R. J. Mol. Biol. (2006) [Pubmed]
  17. Effects of oral D-tagatose, a stereoisomer of D-fructose, on liver metabolism in man as examined by 31P-magnetic resonance spectroscopy. Buemann, B., Gesmar, H., Astrup, A., Quistorff, B. Metab. Clin. Exp. (2000) [Pubmed]
  18. Continuous D-tagatose production by immobilized thermostable L-arabinose isomerase in a packed-bed bioreactor. Ryu, S.A., Kim, C.S., Kim, H.J., Baek, D.H., Oh, D.K. Biotechnol. Prog. (2003) [Pubmed]
  19. Enzymatic conversion of D-galactose to D-tagatose: heterologous expression and characterisation of a thermostable L-arabinose isomerase from Thermoanaerobacter mathranii. Jørgensen, F., Hansen, O.C., Stougaard, P. Appl. Microbiol. Biotechnol. (2004) [Pubmed]
  20. High production of D-tagatose, a potential sugar substitute, using immobilized L-arabinose isomerase. Kim, P., Yoon, S.H., Roh, H.J., Choi, J.H. Biotechnol. Prog. (2001) [Pubmed]
  21. Characteristics and significance of D-tagatose-induced liver enlargement in rats: An interpretative review. Bär, A. Regulatory toxicology and pharmacology : RTP. (1999) [Pubmed]
  22. Small-bowel absorption of D-tagatose and related effects on carbohydrate digestibility: an ileostomy study. Normén, L., Laerke, H.N., Jensen, B.B., Langkilde, A.M., Andersson, H. Am. J. Clin. Nutr. (2001) [Pubmed]
  23. Increase in D: -tagatose Production Rate by Site-directed Mutagenesis of L: -arabinose Isomerase from Geobacillus thermodenitrificans. Oh, H.J., Kim, H.J., Oh, D.K. Biotechnol. Lett. (2006) [Pubmed]
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