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Chemical Compound Review

Medemycin     [(2S,3S,4R,6S)-6- [(2R,3S,4S,5R,6S)-4...

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Disease relevance of Medemycin


High impact information on Medemycin


Chemical compound and disease context of Medemycin


Biological context of Medemycin


Anatomical context of Medemycin


Associations of Medemycin with other chemical compounds


Gene context of Medemycin

  • Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part VI-1. Acute toxicity in infant mice in comparison with young adult mice [24].

Analytical, diagnostic and therapeutic context of Medemycin

  • Western blots of terminal cisternae (TC), incubated for 15 min at 37 C with 40 microM ivermectin or midecamycin, showed normal amounts of FKBP12 [6].
  • Transformation of the cloned DNA into the S. mycarofaciens blocked mutant 68 and into Streptomyces lividans TK24 resulted in the production of midecamycin-like substances by TLC and HPLC analyses [25].
  • The promoter region of the midecamycin 4"-hydroxyl propionyltransferase gene (mpt) gene was reconstructed by PCR, and ligated with a fragment from the midecamycin producing strain (Streptomyces mycarofaciens var. 68) which contained fairly strong promoter activity (PLF) [26].


  1. In vitro activity of midecamycin, a new macrolide antibiotic. Neu, H.C. Antimicrob. Agents Chemother. (1983) [Pubmed]
  2. Inactivation of the macrolide antibiotics erythromycin, midecamycin, and rokitamycin by pathogenic Nocardia species. Yazawa, K., Mikami, Y., Sakamoto, T., Ueno, Y., Morisaki, N., Iwasaki, S., Furihata, K. Antimicrob. Agents Chemother. (1994) [Pubmed]
  3. A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens. Hara, O., Hutchinson, C.R. J. Bacteriol. (1992) [Pubmed]
  4. In vitro activity of midecamycin diacetate against Mycoplasma pneumoniae and Chlamydia pneumoniae. Pereyre, S., de Barbeyrac, B., Renaudin, H., Poutiers, F., Bébéar, C., Bébéar, C.M. J. Antimicrob. Chemother. (2001) [Pubmed]
  5. Effects of the macrolide antibiotic, midecamycin, on Staphylococcus aureus product-induced Th2 cytokine response in patients with atopic dermatitis. Matsui, K., Nishikawa, A. J. Interferon Cytokine Res. (2004) [Pubmed]
  6. Effects of ivermectin and midecamycin on ryanodine receptors and the Ca2+-ATPase in sarcoplasmic reticulum of rabbit and rat skeletal muscle. Ahern, G.P., Junankar, P.R., Pace, S.M., Curtis, S., Mould, J.A., Dulhunty, A.F. J. Physiol. (Lond.) (1999) [Pubmed]
  7. Formation of inactive cytochrome P-450 Fe(II)-metabolite complexes with several erythromycin derivatives but not with josamycin and midecamycin in rats. Larrey, D., Tinel, M., Pessayre, D. Biochem. Pharmacol. (1983) [Pubmed]
  8. Acute hepatitis during hypersensitivity syndrome due to midecamycin. Thevenot, T., Mathurin, P., Martinez, F., Moussalli, J., Poynard, T., Opolon, P., Chosidow, O. European journal of gastroenterology & hepatology. (1997) [Pubmed]
  9. Airborne allergic contact dermatitis from kitasamycin and midecamycin. Dooms-Goossens, A., Bedert, R., Degreef, H., Vandaele, M. Contact Derm. (1990) [Pubmed]
  10. In vitro and in vivo antibacterial activity of 9,3"-Di-o-acetyl midecamycin (Mom), a new macrolide antibiotic. Kawaharajo, K., Sekizawa, Y., Inoue, M. J. Antibiot. (1981) [Pubmed]
  11. Effects of macrolides on ultrastructure of Staphylococcus aureus during postantibiotic phase. Watanabe, T., Kanno, M., Tejima, E., Orikasa, Y. Drugs under experimental and clinical research. (1992) [Pubmed]
  12. Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part VI-2. Acute toxicity in infant rats in comparison with young adult rats. Yokota, M., Takeda, U., Odaki, M., Moriguchi, M., Watanabe, H., Ishiwatari, N., Hata, T., Shindo, Y., Ishii, H., Yamamoto, Y. The Japanese journal of antibiotics. (1984) [Pubmed]
  13. Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miokamycin). Part I-1. Acute toxicity in mice. Yokota, M., Takeda, U., Odaki, M., Sasaki, H., Kawaoto, H., Itoh, T., Koeda, T. The Japanese journal of antibiotics. (1984) [Pubmed]
  14. Combined action of semisynthetic penicillin and macrolide antibiotic on Pseudomonas aeruginosa in vitro and in vivo. Kawaharajo, K., Kasai, T., Homma, J.Y. Jpn. J. Exp. Med. (1979) [Pubmed]
  15. Modifications of a macrolide antibiotic midecamycin (SF-837). I. Synthesis and structure of 9,3''-diacetylmidecamycin. Omoto, S., Iwamatsu, K., Inouye, S., Niida, T. J. Antibiot. (1976) [Pubmed]
  16. Subcloning and expression of midecamycin polyketide synthase genes from Streptomyces mycarofaciens 1748. Zhu, X., Wang, Y., Jin, L., Xu, X. Chin. J. Biotechnol. (1991) [Pubmed]
  17. A study of esterase--its application to biotransformation of midecamycin derivatives. Morikawa, M., Inoue, M., Tsuboi, M., Shomura, T., Someya, S., Murata, S., Umemura, K., Sugiura, M. J. Pharmacobio-dyn. (1982) [Pubmed]
  18. Plasmid DNA in midecamycin-producing strain Streptomyces mycarofaciens 1748. Wang, Y.G., Gong, L.M. Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsüeh k'o hsüeh yüan, Chung-kuo hsieh ho i k'o ta hsüeh hsüeh pao. (1986) [Pubmed]
  19. Effect of midecamycin acetate on gastrointestinal motility in humans. Sifrim, D., Janssens, J., Vantrappen, G. International journal of clinical pharmacology research. (1992) [Pubmed]
  20. Influence of midecamycin acetate, a new macrolide antibiotic, on bactericidal action of human polymorphonuclear leukocytes. Nishimura, T., Tabuki, K. Journal of chemotherapy (Florence, Italy) (1989) [Pubmed]
  21. Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-8. Toxicity of metabolites of miocamycin: acute toxicity of Mb6 in rats. Yokota, M., Takeda, U., Odaki, M., Sasaki, H., Kawaoto, H., Watanabe, H., Ishiwatari, N., Koeda, T. The Japanese journal of antibiotics. (1984) [Pubmed]
  22. Influence of macrolides on guanosine diphospho-D-mannose dehydrogenase activity in Pseudomonas biofilm. Mitsuya, Y., Kawai, S., Kobayashi, H. J. Infect. Chemother. (2000) [Pubmed]
  23. Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans. Horikawa, M., Kato, Y., Tyson, C.A., Sugiyama, Y. Drug Metab. Pharmacokinet. (2003) [Pubmed]
  24. Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part VI-1. Acute toxicity in infant mice in comparison with young adult mice. Yokota, M., Takeda, U., Odaki, M., Moriguchi, M., Itoh, T., Hata, T., Shindo, Y., Yoshida, C. The Japanese journal of antibiotics. (1984) [Pubmed]
  25. Cloning of midecamycin biosynthetic genes from Streptomyces mycarofaciens 1748. Wang, Y.G., Hutchinson, C.R. Chin. J. Biotechnol. (1989) [Pubmed]
  26. Increase of the expression of midecamycin 4"-hydroxyl propionyltransferase gene (mpt) by a promoter-like fragment from the midecamycin producing strain. Gu, H., Wang, Y., Xu, X., Wei, X., Fong, M. Chin. J. Biotechnol. (1996) [Pubmed]
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