The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1L1895     1-[4-[[(4S)-2-(2,4- dichlorophenyl)-2-(1,2...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of terconazole


High impact information on terconazole

  • However, these relationships were not always noted with other Candida spp.: in particular, the growth of C. glabrata and C. parapsilosis isolates tended to be greater at 37 degrees C than at 25 degrees C in the presence of the azole-derivative antifungal agents itraconazole and terconazole [6].
  • The inhibitory potency of terconazole on yeast cell viability varied with the strain and species of Candida tested [7].
  • This study further characterizes the effects of terconazole in vitro on yeast cell growth, viability, and morphology [7].
  • Therefore, the PASCO method is a suitable alternative procedure for the testing of the antifungal susceptibilities of the medically important Candida spp. and C. neoformans against a range of antifungal agents with the exceptions only of miconazole and clotrimazole and of terconazole against C. krusei isolates [8].
  • Selective inhibition of 14 alpha-desmethyl sterol synthesis in Candida albicans by terconazole, a new triazole antimycotic [9].

Chemical compound and disease context of terconazole


Biological context of terconazole


Anatomical context of terconazole


Associations of terconazole with other chemical compounds


Gene context of terconazole

  • The high affinity and selectivity of terconazole for fungal cytochrome P-450 and its potent in vitro and in vivo activity indicate that the drug may well become a significant agent for the treatment of fungal disease [16].

Analytical, diagnostic and therapeutic context of terconazole


  1. Antimycotic azoles. 6. Synthesis and antifungal properties of terconazole, a novel triazole ketal. Heeres, J., Hendrickx, R., Van Cutsem, J. J. Med. Chem. (1983) [Pubmed]
  2. Comparison of 0.8% and 1.6% terconazole cream in severe vulvovaginal candidiasis. Schmitt, C., Sobel, J., Meriwether, C. Obstetrics and gynecology. (1990) [Pubmed]
  3. The in vitro activity of terconazole against yeasts: its topical long-acting therapeutic efficacy in experimental vaginal candidiasis in rats. Van Cutsem, J. Am. J. Obstet. Gynecol. (1991) [Pubmed]
  4. Effects of terconazole and other azole antifungal agents on the sterol and carbohydrate composition of Candida albicans. Pfaller, M.A., Riley, J., Koerner, T. Diagn. Microbiol. Infect. Dis. (1990) [Pubmed]
  5. Prevention of recurrent vaginal candidiasis with weekly terconazole cream. Stein, G.E., Mummaw, N.L., Schooley, S.L. The Annals of pharmacotherapy. (1996) [Pubmed]
  6. Effects of temperature on anti-Candida activities of antifungal antibiotics. Odds, F.C. Antimicrob. Agents Chemother. (1993) [Pubmed]
  7. Anticandidal activities of terconazole, a broad-spectrum antimycotic. Tolman, E.L., Isaacson, D.M., Rosenthale, M.E., McGuire, J.L., Van Cutsem, J., Borgers, M., Van den Bossche, H. Antimicrob. Agents Chemother. (1986) [Pubmed]
  8. Comparative evaluation of PASCO and national committee for clinical laboratory standards M27-A broth microdilution methods for antifungal drug susceptibility testing of yeasts. Arthington-Skaggs, B.A., Motley, M., Warnock, D.W., Morrison, C.J. J. Clin. Microbiol. (2000) [Pubmed]
  9. Selective inhibition of 14 alpha-desmethyl sterol synthesis in Candida albicans by terconazole, a new triazole antimycotic. Isaacson, D.M., Tolman, E.L., Tobia, A.J., Rosenthale, M.E., McGuire, J.L., Vanden Bossche, H., Janssen, P.A. J. Antimicrob. Chemother. (1988) [Pubmed]
  10. Anti-inflammatory and anti-itch activity of sertaconazole nitrate. Liebel, F., Lyte, P., Garay, M., Babad, J., Southall, M.D. Arch. Dermatol. Res. (2006) [Pubmed]
  11. Single dose oral fluconazole vs intravaginal terconazole in treatment of Candida vaginitis. Comparison and pilot study. Slavin, M.B., Benrubi, G.I., Parker, R., Griffin, C.R., Magee, M.J. The Journal of the Florida Medical Association. (1992) [Pubmed]
  12. In vitro susceptibility of clinical yeast isolates to fluconazole and terconazole. Cooper, C.R., McGinnis, M.R. Am. J. Obstet. Gynecol. (1996) [Pubmed]
  13. Susceptibility of clinical isolates of Candida spp. to terconazole and other azole antifungal agents. Pfaller, M.A., Gerarden, T. Diagn. Microbiol. Infect. Dis. (1989) [Pubmed]
  14. Comparative in vitro activity of antimycotic agents against pathogenic vaginal yeast isolates. Lynch, M.E., Sobel, J.D. J. Med. Vet. Mycol. (1994) [Pubmed]
  15. Comparison of terconazole and clotrimazole vaginal tablets in the treatment of vulvovaginal candidosis. Kjaeldgaard, A. Pharmatherapeutica. (1986) [Pubmed]
  16. Terconazole. Pharmacology of a new antimycotic agent. Cauwenbergh, G., Vanden Bossche, H. The Journal of reproductive medicine. (1989) [Pubmed]
  17. Terconazole--a new antifungal agent for vulvovaginal candidiasis. Weisberg, M. Clinical therapeutics. (1989) [Pubmed]
WikiGenes - Universities