Disease relevance of Sertaconazole nitrate

• It is concluded that once-daily topical sertaconazole is an effective and well-tolerated treatment for pediatric patients with dermatophytosis [1].
• This article reviews the antifungal activity of sertaconazole nitrate against major fungal pathogens that cause and complicate tinea pedis [2].
• In addition, sertaconazole nitrate inhibited contact hypersensitivity and scratching responses in a murine model of pruritus [3].
• The anti-inflammatory activities of eight anti-fungal agents (butoconazole, ciclopirox olamine, fluconazole, miconazole nitrate, sertaconazole nitrate, terconazole, tioconazole and ketoconazole) were compared in a number of preclinical models of dermal inflammation and pruritus [3].
• In vivo activity of sertaconazole in experimental candidiasis in the mouse [4].

High impact information on Sertaconazole nitrate

• In-vitro antifungal activity of sertaconazole, bifonazole, ketoconazole, and miconazole against yeasts of the Candida genus [5].
• Review of in vitro activity of sertaconazole nitrate in the treatment of superficial fungal infections [2].
• Single-dose sertaconazole vaginal tablet treatment of vulvovaginal candidiasis [6].
• In this study, the concentrations of sertaconazole in the nails were shown to be well above the MIC values for pathogenic fungi relevant to onychomycosis [7].
• In the present study, the pharmacokinetics of sertaconazole nail patches, developed for treatment of onychodystrophy and onychomycosis, were investigated in healthy volunteers [7].

Chemical compound and disease context of Sertaconazole nitrate

• Multi-centre double-blind trial on the efficacy and safety of sertaconazole 2% cream in comparison with miconazole 2% cream on patients suffering from cutaneous mycoses [8].
• Six-month chronic oral toxicity studies of 7-chloro-3-[1-(2, 4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy-methyl] benzo[b]thiophene (sertaconazole, FI-7045, CAS 99592-32-2) were carried out in rats and ferrets [9].

Biological context of Sertaconazole nitrate

• Sertaconazole in the treatment of mycoses: from dermatology to gynecology [10].
• Various studies carried out in animal models, clinical and toxicologic trials have confirmed the value of sertaconazole in the topical treatment of superficial mycoses in dermatology and gynecology [11].
• Reproduction toxicity of sertaconazole. Segment II (teratology) and Segment III (peri-postnatal toxicity) [12].

Anatomical context of Sertaconazole nitrate

• While butoconazole, ciclopirox olamine, fluconazole, and miconazole nitrate were all found to have anti-inflammatory activity, only sertaconazole nitrate reduced the release of cytokines from activated lymphocytes and mitigated inflammation in animal models of irritant contact dermatitis and neurogenic inflammation [3].
• Consequently, the negligible irritant effect of sertaconazole gel on a type of epithelium that is extremely sensitive, i.e. the cornea, confirms the good tolerance of this new antifungal gel on other structures such as the skin and mucous membranes [13].
• The dermal administration of 2% sertaconazole to rats, in which edema was induced by application of croton oil in the external ear, induced a 39.8% reduction of edema [14].

Associations of Sertaconazole nitrate with other chemical compounds

• In-vitro antifungal activity of sertaconazole, econazole, and bifonazole against Candida spp [15].
• In vitro activity of sertaconazole against dermatophyte isolates with reduced fluconazole susceptibility [16].
• Determination of sertaconazole nitrate, a new imidazole antifungal, by high-performance liquid chromatography [17].
• Against dermatophytes, MIC for terbinafine (0.05 mg/l) was lower than sertaconazole (MIC 0.41 mg/l) and bifonazole (MIC 1.04 mg/l) [18].
• Comparative study of the in vitro antifungal activity of bifonazole, naftifine and sertaconazole against yeasts [19].

Gene context of Sertaconazole nitrate

• The activity of 7-chloro-3-[1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl) ethoxy-methyl]benzo[b]thiophene (sertaconazole, FI-7045, CAS 99592-32,2) was studied in a randomized parallel double-blind clinical trial on 21 patients suffering from Pityriasis versicolor (confirmed by KOH microscopic examination and exploration with Wood's light) [20].
• The acute toxicity of 7-chloro-3-[1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy- methyl]benzo[b]thiophene (sertaconazole, FI-7045, CAS 99592-32-2) was evaluated in mice and rats after single administration by oral, subcutaneous and intraperitoneal routes [21].

Analytical, diagnostic and therapeutic context of Sertaconazole nitrate

• Sertaconazole/hydroxypropyl-beta-cyclodextrin complexation: isothermal titration calorimetry and solubility approaches [22].
• An open-label, multicenter study was conducted to assess the efficacy and tolerability of sertaconazole in children in primary care [1].
• Complexation of sertaconazole (SN) with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was characterized by phase-solubility diagram measurements and isothermal calorimetry (ITC) in aqueous medium, and by differential scanning calorimetry (DSC), Raman spectroscopy and X-ray diffractometry in solid state [22].
• These studies demonstrate that topical administration of clinically relevant concentrations of sertaconazole nitrate resulted in an efficacious anti-inflammatory activity against a broad spectrum of dermal inflammation models and itch [3].
• According to these results, and having furthermore proved the absorption of the test substance after oral administration, sertaconazole was concluded to be very safe in the event of overdose or accidental ingestion [21].

References