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Chemical Compound Review:

PGFM (Z)-7-[(1R,2R,3R,5S)-3,5- dihydroxy-2-(3...

Synonyms: Dhk-pgf2alpha, CHEBI:63976, D4143_SIGMA, HMDB04685, BML1-G01, ...

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Disease relevance of PGFM

Blood concentrations of progesterone, 13,14-dihydro-15-keto-prostaglandin F2alpha (PGFM) and endotoxin, and uterine fluid concentrations of prostaglandin E(2) (PGE(2)), PGFM and endotoxin were evaluated in 14 dairy cows with puerperal endometritis (mild (n=6) and heavy (n=8)) [1].
Before and after the provocation as in the three patients with exercise-induced asthma, peripheral venous blood sampled and analyzed for 15-keto-13,14-dihydro-PGF2alpha using combined gas--liquid chromatography-mass spectrometry [2].

High impact information on PGFM

The activity of PGDH was assessed by measurement of 13,14-dihydro-15-keto-PGF2alpha [3].
The basal output of 13,14-dihydro-15-keto-PGF2alpha was lower in placenta or chorion collected at spontaneous labor than in that obtained at elective cesarean section [3].
The effect of OTA on OT-induced increase in plasma concentration of 13,14-dihydro-15-keto-prostaglandin F2alpha metabolite (PGFM) was studied in 24 late-pregnant cows [4].
Measurements were made of plasma concentrations of arginine vasopressin, 15-keto-13,14-dihydroprostaglandin F2 alpha, oestradiol-17 beta, progesterone, ethynyloestradiol, levonorgestrel, FSH, LH and prolactin, and serum osmolality was measured [5].
Prostaglandin E (PGE), prostaglandin F (PGF) and 13,14-dihydro-15-ketoprostaglandin F (PGFM) have been measured in umbilical cord plasma obtained immediately after delivery by elective Caesarean section [6].

Biological context of PGFM

To elucidate the role of prostaglandins in initiating uterine contractions we studied the concentrations of 13,14-dihydro-15-keto-PGE2 (PGE2-M) and 13,14-dihydro-15-keto-PGF2alpha (PGF2alpha-M) in peripheral plasma of pregnant patients [7].
The concentrations of 15-keto-13,14-dihydroprostaglandin F2 alpha were lower during the postpartum period in heifers than gave birth to Limousin calves than in those that had Ayrshire calves [8].
This model was used to evaluate non-enzymatic [8-Iso-prostaglandin F2alpha (8-Iso-PGF2alpha)] and enzymatic [15-keto-13,14-dihydro-prostaglandin F2alpha (15-K-DH-PGF2alpha)] lipid peroxidation, respectively, in relation to survival [9].
Validation of a sensitive enzymeimmunoassay for 13,14-dihydro-15-keto-PGF2alpha in buffalo plasma and its application for reproductive health status monitoring [10].
The objective of this study was to determine if the primary circulating metabolite of PGF2alpha, 13,14-dihydro-15-keto-PGF2alpha (PGFM), is biologically active and would induce luteolysis in nonpregnant mares [11].

Anatomical context of PGFM

Highly sensitive second antibody format enzymeimmunoassay for determination of 13,14-dihydro-15-keto-PGF2alpha in blood plasma of mithun (Bos frontalis) [12].
Aqueous humor levels of PGF2alpha and its metabolite 13,14-dihydro-15-keto-PGF2alpha were measured using enzyme-immunoassay [13].

Associations of PGFM with other chemical compounds

Ewes then received an oxytocin challenge (1 microgram in 0.9% NaCl), and blood samples were taken just before and every 10 min for 1 h after the challenge; these were measured for 13,14-dihydro-15-ketoprostaglandin F 2 alpha (PGFM), the stable metabolite of prostaglandin F 2 alpha [14].
Multiparous beef cows (n = 7) were used to evaluate peripartum changes and interactions among body temperature (BT) and circulating progesterone (P4), estradiol-17beta (E2), triiodothyronine (T3), cortisol, thyroxine (T4), and 13,14-dihydro-15-keto-prostaglandin F2alpha (PGFM) concentrations [15].
Serum luteinizing hormone, 13,14-dihydro-15-keto-prostaglandin F2alpha and cortisol profiles during postpartum anestrus in Brahman and Angus cows [16].
However, oestradiol-treated ewes had lower plasma concentrations of 15-keto-13,14-dihydro-prostaglandin F2alpha (P<0.01), alpha1-acid glycoprotein (P<0.05) and ceruloplasmin (P<0.001); but, not haptoglobin [17].

Gene context of PGFM

Radioimmunoassay of 15-keto-13,14-dihydro-prostaglandin F2alpha: an index for inflammation via cyclooxygenase catalysed lipid peroxidation [18].
Retention of a functional corpus luteum and peripheral concentrations of 13,14-dihydro-15-keto-prostaglandin F2alpha following metestrus administration of Syncro-Mate-B [19].

Analytical, diagnostic and therapeutic context of PGFM

An antiserum to 13,14-dihydro-15-keto-prostaglandin F2alpha (PGF2alphaM) was prepared and a radioimmunoassay evaluated in various reproductive states [20].

References

Relationship between endotoxin and prostaglandin (PGE2 and PGFM) concentrations and ovarian function in dairy cows with puerperal endometritis. Mateus, L., Lopes da Costa, L., Diniz, P., Ziecik, A.J. Anim. Reprod. Sci. (2003) [Pubmed]
Aspects of prostaglandin action in asthma. Svanborg, N., Hedqvist, P., Gréen, K. Advances in prostaglandin and thromboxane research. (1976) [Pubmed]
Steroid regulation of prostaglandin dehydrogenase activity and expression in human term placenta and chorio-decidua in relation to labor. Patel, F.A., Clifton, V.L., Chwalisz, K., Challis, J.R. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
Oxytocin antagonist [1-D(CH2)5,Tyr(ME)2,Thr4,Tyr-NH2(9)]ornithine vasotocin inhibits oxytocin-induced prostaglandin F2alpha release in late-pregnant cows. Fuchs, A.R., Fields, M.J., Chang, S.M., Thatcher, W.W., Willard, C.C., Randel, R.D. Biol. Reprod. (1997) [Pubmed]
Plasma concentrations of vasopressin and a prostaglandin F2 alpha metabolite in women with primary dysmenorrhoea before and during treatment with a combined oral contraceptive. Hauksson, A., Akerlund, M., Forsling, M.L., Kindahl, H. J. Endocrinol. (1987) [Pubmed]
Prostaglandins in umbilical plasma at elective caesarean section. Bibby, J.G., Brunt, J.D., Hodgson, H., Mitchell, M.D., Anderson, A.B., Turnbull, A.C. British journal of obstetrics and gynaecology. (1979) [Pubmed]
Plasma prostaglandin metabolites in human labor. Lackritz, R., Tulchinsky, D., Ryan, K.J., Levine, L. Am. J. Obstet. Gynecol. (1978) [Pubmed]
Influence of breed of fetus on periparturient endocrine responses and subsequent milk production of Ayrshire dams. Guilbault, L.A., Roy, G.L., Beckers, J.F., Dufour, J.J. J. Dairy Sci. (1990) [Pubmed]
Lipid peroxidation induced by an early inflammatory response in endotoxaemia. Basu, S., Eriksson, M. Acta anaesthesiologica Scandinavica. (2000) [Pubmed]
Validation of a sensitive enzymeimmunoassay for 13,14-dihydro-15-keto-PGF2alpha in buffalo plasma and its application for reproductive health status monitoring. Mishra, D.P., Meyer, H.H., Prakash, B.S. Anim. Reprod. Sci. (2003) [Pubmed]
Effect of PGF2alpha and 13,14-dihydro-15-keto-PGF2alpha (PGFM) on corpora luteal function in nonpregnant mares. Vanderwall, D.K., Betschart, R.W., Squires, E.L. Theriogenology (2000) [Pubmed]
Highly sensitive second antibody format enzymeimmunoassay for determination of 13,14-dihydro-15-keto-PGF2alpha in blood plasma of mithun (Bos frontalis). Mondal, M., Meyer, H.H., Rajkhowa, C., Prakash, B.S. Prostaglandins Other Lipid Mediat. (2006) [Pubmed]
The effect of latanoprost on aqueous humor PGF2alpha levels in glaucoma patients. Güven, D., Karakurt, A., Saban, E., Hasiripi, H. International ophthalmology. (1999) [Pubmed]
Ovine conceptus secretory proteins and bovine recombinant interferon alpha (1)-1 decrease endometrial oxytocin receptor concentrations in cyclic and progesterone-treated ovariectomized ewes. Vallet, J.L., Lamming, G.E. J. Endocrinol. (1991) [Pubmed]
Body temperature and endocrine interactions before and after calving in beef cows. Lammoglia, M.A., Bellows, R.A., Short, R.E., Bellows, S.E., Bighorn, E.G., Stevenson, J.S., Randel, R.D. J. Anim. Sci. (1997) [Pubmed]
Serum luteinizing hormone, 13,14-dihydro-15-keto-prostaglandin F2alpha and cortisol profiles during postpartum anestrus in Brahman and Angus cows. Stahringer, R.C., Byerley, D.J., Kiser, T.E., Randel, R.D. Theriogenology (1994) [Pubmed]
The effect of oestradiol on postpartum uterine involution in sheep. Sheldon, I.M., Noakes, D.E., Bayliss, M., Dobson, H. Anim. Reprod. Sci. (2003) [Pubmed]
Radioimmunoassay of 15-keto-13,14-dihydro-prostaglandin F2alpha: an index for inflammation via cyclooxygenase catalysed lipid peroxidation. Basu, S. Prostaglandins Leukot. Essent. Fatty Acids (1998) [Pubmed]
Retention of a functional corpus luteum and peripheral concentrations of 13,14-dihydro-15-keto-prostaglandin F2alpha following metestrus administration of Syncro-Mate-B. Hampton, J.H., Spitzer, J.C., Henricks, D.M., Hix, B.S., Higdon, H.L. J. Anim. Sci. (1999) [Pubmed]
13, 14-dihydro-15-keto-prostaglandin F2alpha concentrations in human plasma and amniotic fluid. Ghodgaonkar, R.B., Dubin, N.H., Blake, D.A., King, T.M. Am. J. Obstet. Gynecol. (1979) [Pubmed]

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