Gene Review:
HPGD - hydroxyprostaglandin dehydrogenase 15-(NAD)
Homo sapiens
Synonyms:
15-PGDH, PGDH, PGDH1, PHOAR1, Prostaglandin dehydrogenase 1, ...
- 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. Yan, M., Rerko, R.M., Platzer, P., Dawson, D., Willis, J., Tong, M., Lawrence, E., Lutterbaugh, J., Lu, S., Willson, J.K., Luo, G., Hensold, J., Tai, H.H., Wilson, K., Markowitz, S.D. Proc. Natl. Acad. Sci. U.S.A. (2004)
- 15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer. Wolf, I., O'Kelly, J., Rubinek, T., Tong, M., Nguyen, A., Lin, B.T., Tai, H.H., Karlan, B.Y., Koeffler, H.P. Cancer Res. (2006)
- Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells. Tong, M., Ding, Y., Tai, H.H. Carcinogenesis (2006)
- 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. Myung, S.J., Rerko, R.M., Yan, M., Platzer, P., Guda, K., Dotson, A., Lawrence, E., Dannenberg, A.J., Lovgren, A.K., Luo, G., Pretlow, T.P., Newman, R.A., Willis, J., Dawson, D., Markowitz, S.D. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression. Mann, J.R., Backlund, M.G., Buchanan, F.G., Daikoku, T., Holla, V.R., Rosenberg, D.W., Dey, S.K., DuBois, R.N. Cancer Res. (2006)
- 15-Hydroxyprostaglandin dehydrogenase in the bovine endometrium during the oestrous cycle and early pregnancy. Parent, M., Madore, E., MacLaren, L.A., Fortier, M.A. Reproduction (2006)
- Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus. Coggins, K.G., Latour, A., Nguyen, M.S., Audoly, L., Coffman, T.M., Koller, B.H. Nat. Med. (2002)
- Site-directed mutagenesis of the conserved tyrosine 151 of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase yields a catalytically inactive enzyme. Ensor, C.M., Tai, H.H. Biochem. Biophys. Res. Commun. (1991)
- Regulation of synthesis and activity of NAD(+)-dependent 15-hydroxy-prostaglandin dehydrogenase (15-PGDH) by dexamethasone and phorbol ester in human erythroleukemia (HEL) cells. Xun, C.Q., Ensor, C.M., Tai, H.H. Biochem. Biophys. Res. Commun. (1991)
- Expression of the cDNA for NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase as a catalytically active enzyme in Escherichia coli. Ensor, C.M., Tai, H.H. Prostaglandins Leukot. Essent. Fatty Acids (1992)
- Regulation of 15-hydroxy prostaglandin dehydrogenase by corticotrophin-releasing hormone through a calcium-dependent pathway in human chorion trophoblast cells. McKeown, K.J., Challis, J.R. J. Clin. Endocrinol. Metab. (2003)
- Prostaglandin dehydrogenase and the initiation of labor. Challis, J.R., Patel, F.A., Pomini, F. Journal of perinatal medicine. (1999)
- 15-Hydroxyprostaglandin dehydrogenase can be induced by dexamethasone and other glucocorticoids at the therapeutic level in A549 human lung adenocarcinoma cells. Tong, M., Tai, H.H. Arch. Biochem. Biophys. (2005)
- IL-4 regulates COX-2 and PGE(2) production in human non-small cell lung cancer. Cui, X., Yang, S.C., Sharma, S., Heuze-Vourc'h, N., Dubinett, S.M. Biochem. Biophys. Res. Commun. (2006)
- Prostaglandin catabolizing enzymes. Tai, H.H., Ensor, C.M., Tong, M., Zhou, H., Yan, F. Prostaglandins Other Lipid Mediat. (2002)
- Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha. Otani, T., Yamaguchi, K., Scherl, E., Du, B., Tai, H.H., Greifer, M., Petrovic, L., Daikoku, T., Dey, S.K., Subbaramaiah, K., Dannenberg, A.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Regulation of prostaglandin availability in human fetal lung by differential localisation of prostaglandin H synthase-1 and prostaglandin dehydrogenase. Conner, C.E., Kelly, R.W., Hume, R. Histochem. Cell Biol. (2001)
- Synergistic induction of the nicotinamide adenine dinucleotide-linked 15-hydroxyprostaglandin dehydrogenase by an androgen and interleukin-6 or forskolin in human prostate cancer cells. Tong, M., Tai, H.H. Endocrinology (2004)
- Kinetics of IL-10-induced gene expression in human macrophages. Antoniv, T.T., Park-Min, K.H., Ivashkiv, L.B. Immunobiology (2005)
- Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells. Tong, M., Ding, Y., Tai, H.H. Biochem. Pharmacol. (2006)
- Cytokeratin 20, AN43, PGDH, and COX-2 expression in transitional and squamous cell carcinoma of the bladder. Gee, J.R., Montoya, R.G., Khaled, H.M., Sabichi, A.L., Grossman, H.B. Urol. Oncol. (2003)
- 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase 2 messenger ribonucleic acid expression and immunohistochemical localization in human cervical tissue during term and preterm labor. Törnblom, S.A., Patel, F.A., Byström, B., Giannoulias, D., Malmström, A., Sennström, M., Lye, S.J., Challis, J.R., Ekman, G. J. Clin. Endocrinol. Metab. (2004)
- Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts. Gao, L., He, P., Sha, J., Liu, C., Dai, L., Hui, N., Ni, X. Endocrinology (2007)
- Prostaglandin dehydrogenase and prostaglandin levels in periovulatory follicles: implications for control of primate ovulation by prostaglandin E2. Duffy, D.M., Dozier, B.L., Seachord, C.L. J. Clin. Endocrinol. Metab. (2005)
- Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term. Patel, F.A., Funder, J.W., Challis, J.R. J. Clin. Endocrinol. Metab. (2003)