Disease relevance of deuterium

• Protein-lipid interactions in biological and model membrane systems. Deuterium NMR of Acholeplasma laidlawii B, Escherichia coli, and cytochrome oxidase systems containing specifically deuterated lipids [1].
• This study compared the measurements of total body water (TBW) by 58% body weight (TBW58%), the Watson equation (TBWWV) and bioelectric impedance (TBWBIA) with the gold standard, Deuterium oxide (TBWD2O) dilution method in twenty continuous ambulatory peritoneal dialysis (CAPD) patients [2].
• Effect of cholesterol and lanosterol on the structure and dynamics of the cell membrane of Mycoplasma capricolum. Deuterium nuclear magnetic resonance study [3].
• Dynamics of the three methionyl side chains of Streptomyces subtilisin inhibitor. Deuterium NMR studies in solution and in the solid state [4].
• Local Stability of Rhodobacter capsulatus Cytochrome c(2) Probed by Solution Phase Hydrogen/Deuterium Exchange and Mass Spectrometry [5].

Psychiatry related information on deuterium

• Physical studies of cell surface and cell membrane structure. Deuterium nuclear magnetic resonance studies of N-palmitoylglucosylceramide (cerebroside) head group structure [6].

High impact information on deuterium

• This consistent with predictions derived from an external coincidence model for photoperiodic time measurement: Deuterium oxide changes phase relationships between the light-dark cycle and the circadian system, the hamster's daily photosensitive phase is stimulated with light during short days, and the testes remain large [7].
• Mapping ERK2-MKP3 Binding Interfaces by Hydrogen/Deuterium Exchange Mass Spectrometry [8].
• METHODS: Deuterium labelled sitosterol and campesterol, and unlabelled sitostanol were constantly infused together with a liquid formula using a duodenal perfusion technique [9].
• PAS Domain Allostery and Light-induced Conformational Changes in Photoactive Yellow Protein upon I(2) Intermediate Formation, Probed with Enhanced Hydrogen/Deuterium Exchange Mass Spectrometry [10].
• On average, DXA resulted in higher FFM values than did Deu in COPD patients (3.4 kg; P < 0.001) and in healthy volunteers (2.1 kg; P < 0.001) [11].

Chemical compound and disease context of deuterium

• Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli. 2. Deuterium solvent isotope effects [12].

Biological context of deuterium

• CONCLUSIONS: DXA appears to be a suitable alternative method to Deu for assessing body composition and is also of value in identifying bone mineral loss in COPD patients, and is therefore applicable in the clinical evaluation of these patients [11].
• Hydrogen/Deuterium Scrambling during Quadrupole Time-of-Flight MS/MS Analysis of a Zinc-Binding Protein Domain [13].
• Gas-phase kinetics and activation parameters for thermal 1,5-hydrogen shifts interconverting monodeuterium-labeled 1,3-cyclohexadienes [14].

Anatomical context of deuterium

• RESULTS: Deuterium oxide was rapidly absorbed from the gastrointestinal tract of all horses, and reached peak (mean +/- SD) plasma concentration (1,454.4 +/- 163 delta D/ml or parts/thousand) 1 hour after administration [15].

Associations of deuterium with other chemical compounds

• Lipid solvation of cytochrome c oxidase. Deuterium, nitrogen-14, and phosphorus-31 nuclear magnetic resonance studies on the phosphocholine head group and on cis-unsaturated fatty acyl chains [16].
• Investigation of Ligand Interactions with Human RXRalpha by Hydrogen/Deuterium Exchange and Mass Spectrometry [17].
• By neutron diffraction experiments, we have succeeded in determining most of the hydrogen (H) and deuterium (D) atomic positions in the decameric d(CCATTAATGG)2 duplex [18].
• Three of these fields have been shown previously to resemble ones found in CANDU (Canadian Deuterium Uranium is a registered trademark of the Atomic Energy of Canada Limited) power plant workplaces [19].

Gene context of deuterium

• The kinetics of thermal equilibrations among monodeuterium-labeled 1,3-cycloheptadienes in the gas phase followed from 154 to 190 degrees C provide activation parameters for the [1,5] shift of a single hydrogen: E(a) = (27.5 +/- 0.9) kcal/mol and log A = 9.7 [corrected] +/- 0 [20].
• On day 2 (08:00 h) of each diet period, 0.7 g deuterium (D) oxide/kg body water was administered and blood was collected every 4 hours over 48 hours for measurement of plasma insulin and glucose-dependent insulinotropic polypeptide (GIP) levels [21].

Analytical, diagnostic and therapeutic context of deuterium

• DESIGN: In a cross-sectional study in 79 COPD patients participating in a pulmonary inpatient program and in 23 healthy volunteers, DXA was compared with deuterium dilution (Deu) in the estimation of FFM [11].
• METHODS: Body composition was measured with dual-energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA) and DEU in 22 stable patients from our heart failure outpatient clinic and 24 healthy age matched controls [22].

References