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Chemical Compound Review

Pentetreotide     2-[2-[[1-[[10-(4-aminobutyl)- 16-benzyl-4...

Synonyms: AC1LCS5N, LS-187384, D01859, 138661-02-6, UNII-G083B71P98, ...
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Disease relevance of DTPA-SMS


High impact information on DTPA-SMS

  • The SSTR2-infected cells bound 111In-pentetreotide sixfold more efficiently than control virus-infected cells and this binding was specifically blocked by nonradiolabeled pentetreotide [6].
  • At the time of diagnosis, none of the patients had radiological evidence of the ectopic source of ACTH, whereas pentetreotide scintigraphy identified the lesion in two of four patients [3].
  • The detection of radioiodine (I-131)-negative metastases of differentiated thyroid carcinoma (DTC) has been hitherto successfully tried by the well-known synthetic somatostatin analogue indium-111-labeled DTPA-octreotide (In-111 pentetreotide) [7].
  • CONCLUSION: Pentetreotide scans may be regarded as a semiobjective tool in the evaluation of Graves' disease, both at initial stages as well as during treatment [8].
  • Pentetreotide seems to have a high affinity for this MIBG-negative neuroblastoma cell line, which exhibited a clearly higher tumour uptake than the 2 other lines [9].

Chemical compound and disease context of DTPA-SMS


Biological context of DTPA-SMS

  • In-111 pentetreotide scintigraphy in patients with neuroblastoma. Comparison with I-131 MIBG, N-Myc oncogene amplification, and patient outcome [15].
  • The clinical experience and the literature confirm that, among the wide variety of tracers and nuclear medicine modalities available today, metaiodobenzylguanidine (MIBG) and DTPA-D-Phe-octreotide (pentetreotide) are the radiopharmaceuticals of current clinical use [16].

Anatomical context of DTPA-SMS


Associations of DTPA-SMS with other chemical compounds


Gene context of DTPA-SMS


Analytical, diagnostic and therapeutic context of DTPA-SMS


  1. Localisation of mesenchymal tumours by somatostatin receptor imaging. Jan de Beur, S.M., Streeten, E.A., Civelek, A.C., McCarthy, E.F., Uribe, L., Marx, S.J., Onobrakpeya, O., Raisz, L.G., Watts, N.B., Sharon, M., Levine, M.A. Lancet (2002) [Pubmed]
  2. Ocular metastases secondary to carcinoid tumors: the utility of imaging with [(123)I]meta-iodobenzylguanidine and [(111)In]DTPA pentetreotide. Isidori, A.M., Kaltsas, G., Frajese, V., Kola, B., Whitelocke, R.A., Plowman, P.N., Britton, K.E., Monson, J.P., Grossman, A.B., Besser, G.M. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  3. Management of occult adrenocorticotropin-secreting bronchial carcinoids: limits of endocrine testing and imaging techniques. Loli, P., Vignati, F., Grossrubatscher, E., Dalino, P., Possa, M., Zurleni, F., Lomuscio, G., Rossetti, O., Ravini, M., Vanzulli, A., Bacchetta, C., Galli, C., Valente, D. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  4. Remission of acromegaly caused by pituitary carcinoma after surgical excision of growth hormone-secreting metastasis detected by 111-indium pentetreotide scan. Greenman, Y., Woolf, P., Coniglio, J., O'Mara, R., Pei, L., Said, J.W., Melmed, S. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  5. Dynamic indium-111-pentetreotide scintigraphy in breast cancer. Bajc, M., Ingvar, C., Palmer, J. J. Nucl. Med. (1996) [Pubmed]
  6. Oncolytic vaccinia virus expressing the human somatostatin receptor SSTR2: molecular imaging after systemic delivery using 111In-pentetreotide. McCart, J.A., Mehta, N., Scollard, D., Reilly, R.M., Carrasquillo, J.A., Tang, N., Deng, H., Miller, M., Xu, H., Libutti, S.K., Alexander, H.R., Bartlett, D.L. Mol. Ther. (2004) [Pubmed]
  7. Tc-99m depreotide imaging of I-131-negative recurrent metastatic papillary thyroid carcinoma. Valsamaki, P., Gotzamani-Psarrakou, A., Tsiouris, S., Molyvda-Athanasopoulou, E., Psarrakos, K., Papantoniou, V., Gerali, S., Zerva, C. Int. J. Cancer (2006) [Pubmed]
  8. Indium-111-pentetreotide in Graves' disease. Kahaly, G., Görges, R., Diaz, M., Hommel, G., Bockisch, A. J. Nucl. Med. (1998) [Pubmed]
  9. Strong uptake of 111In-pentetreotide by an MIBG-negative, xenografted neuroblastoma. Manil, L., Perdereau, B., Barbaroux, C., Brixy, F. Int. J. Cancer (1994) [Pubmed]
  10. Indium In-111 pentetreotide scintigraphy: application to carotid body tumors. Hammond, S.L., Greco, D.L., Lambert, A.T., McBiles, M., Patton, G.M. J. Vasc. Surg. (1997) [Pubmed]
  11. Breast cancer staging using technetium-99m sestamibi and indium-111 pentetreotide single-photon emission tomography. Chiti, A., Agresti, R., Maffioli, L.S., Tomasic, G., Savelli, G., Crippa, F., Pilotti, S., Greco, M., Bombardieri, E. European journal of nuclear medicine. (1997) [Pubmed]
  12. Sensitivity versus specificity in melanoma imaging using iodine-123 iodobenzamide and indium-111 pentetreotide. Hoefnagel, C.A., Rankin, E.M., Valdés Olmos, R.A., Israëls, S.P., Pavel, S., Janssen, A.G. European journal of nuclear medicine. (1994) [Pubmed]
  13. Comparison of In-111 pentetreotide, Tc-99m (V)DMSA and I-123 mlBG scintimaging in neural crest tumors. Limouris, G.S., Giannakopoulos, V., Stavraka, A., Toubanakis, N., Vlahos, L. Anticancer Res. (1997) [Pubmed]
  14. Diagnostic usefulness of radiolabeled pentetreotide scintigraphy and therapeutic efficiency of octreotide in a case of insulinoma. Cuvelier, C., Pochet, J.M., Col, V., Jonard, P., Pauwels, S., Cuvelier, A. Acta clinica Belgica. (1994) [Pubmed]
  15. In-111 pentetreotide scintigraphy in patients with neuroblastoma. Comparison with I-131 MIBG, N-Myc oncogene amplification, and patient outcome. Shalaby-Rana, E., Majd, M., Andrich, M.P., Movassaghi, N. Clinical nuclear medicine. (1997) [Pubmed]
  16. Position of nuclear medicine techniques in the diagnostic work-up of neuroendocrine tumors. Bombardieri, E., Seregni, E., Villano, C., Chiti, A., Bajetta, E. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceu... (2004) [Pubmed]
  17. Effective treatment of bone metastases from a neuroendocrine tumour of the pancreas with high activities of Indium-111-pentetreotide. van der Hiel, B., Stokkel, M.P., Chiti, A., Lucignani, G., Bajetta, E., Pauwels, E.K., Bombardieri, E. Eur. J. Endocrinol. (2003) [Pubmed]
  18. Use of radioguided surgery with [111In]-pentetreotide in the management of an ACTH-secreting bronchial carcinoid causing ectopic Cushing's syndrome. Grossrubatscher, E., Vignati, F., Dalino, P., Possa, M., Belloni, P.A., Vanzulli, A., Bramerio, M., Marocchi, A., Rossetti, O., Zurleni, F., Loli, P. J. Endocrinol. Invest. (2005) [Pubmed]
  19. Radiolabeled somatostatin analog scintigraphy in differentiated thyroid carcinoma. Tenenbaum, F., Lumbroso, J., Schlumberger, M., Caillou, B., Fragu, P., Parmentier, C. J. Nucl. Med. (1995) [Pubmed]
  20. Use of indium-111 pentetreotide somatostatin receptor scintigraphy to detect recurrent thyroid carcinoma in patients without detectable iodine uptake. Garin, E., Devillers, A., Le Cloirec, J., Bernard, A.M., Lescouarc'h, J., Herry, J.Y., Reubi, J.C., Bourguet, P. European journal of nuclear medicine. (1998) [Pubmed]
  21. Whole body and tomographic scan with 111In-pentetreotide: preliminary data. Gregianin, M., Macrì, C., Bui, F., Varotto, L., Zucchetta, P. The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR). (1995) [Pubmed]
  22. Intertumoural Variability in Functional Imaging within Patients Suffering from Neuroendocrine Tumours. An Observational, Cross-Sectional Study. Quigley, A.M., Buscombe, J.R., Shah, T., Gnanasegaran, G., Roberts, D., Caplin, M.E., Hilson, A.J. Neuroendocrinology (2005) [Pubmed]
  23. Somatostatin analogues for somatostatin-receptor-mediated radiotherapy of cancer. Stolz, B., Smith-Jones, P., Albert, R., Tolcsvai, L., Briner, U., Ruser, G., Mäcke, H., Weckbecker, G., Bruns, C. Digestion (1996) [Pubmed]
  24. Somatostatin receptor scintigraphy predicts impending cardiac allograft rejection before endomyocardial biopsy. Aparici, C.M., Narula, J., Puig, M., Camprecios, M., Martín, J.C., Tembl, A., Flotats, A., Estorch, M., Catafau, A.M., Bernà, L., Ballester, M., Carrió, I. European journal of nuclear medicine. (2000) [Pubmed]
  25. OctreoScan 111 for imaging of a somatostatin receptor-positive islet cell tumor in rat. Bruns, C., Stolz, B., Albert, R., Marbach, P., Pless, J. Horm. Metab. Res. Suppl. (1993) [Pubmed]
  26. The incidental discovery of follicular thyroid cancer with in-111 pentetreotide scintigraphy in a patient with carcinoid tumor of the lung. Villa, G., Ratto, G.B., Carletto, M., Rouhanifar, H., Piccardo, A., Tommasi, L., Altrinetti, V., Mereu, C., Mariani, G. Clinical nuclear medicine. (2003) [Pubmed]
  27. Differentiation between carcinoid and sarcoid with F-18 FDG PET and In-111 pentetreotide. Avram, A.M., Mackie, G.C., Schneider, B.J., Kalemkerian, G.P., Shulkin, B.L. Clinical nuclear medicine. (2006) [Pubmed]
  28. Increased uptake of indium-111 pentetreotide up to 10 years after external thoracic irradiation: report of two cases. Stoffel, M., Jamar, F., Donckier, J., Hainaut, P., Decoster, P., Beckers, C., Pauwels, S. European journal of nuclear medicine. (1996) [Pubmed]
  29. Somatostatin receptor scintigraphy in thyroid eye disease. Kahaly, G.J., Förster, G.J. Thyroid (1998) [Pubmed]
  30. The role of octreoscan in thyroid eye disease. Krassas, G.E., Kahaly, G.J. Eur. J. Endocrinol. (1999) [Pubmed]
  31. 111Indium pentetreotide scan detection of familial paragangliomas. Myssiorek, D., Palestro, C.J. Laryngoscope (1998) [Pubmed]
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