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Chemical Compound Review

Noriclan     (1S,2R,4R,5R,6R,7S,8R,11R,12S, 13R,15R,17S)...

Synonyms: Divitross, Valodin, Dirithromycin, Diritromicina, Dirithromycine, ...
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Disease relevance of AIDS007805


Psychiatry related information on AIDS007805


High impact information on AIDS007805

  • Therefore, on the limited basis of single-dose administration, no modifications of dirithromycin dosage seem to be required even for patients with class B liver cirrhosis [5].
  • The number of bacteria adherent to the mucosa was reduced, although the tissue that had been incubated with dirithromycin (0.125 and 0.5 microg/ml) did not inhibit bacterial growth [2].
  • Dirithromycin did not affect the ciliary beat frequency of the nasal epithelium or the transport of mucus on bovine trachea, but dirithromycin (1 microg/ml) did reduce the slowing of the ciliary beat frequency and the damage to the nasal epithelium caused by H. influenzae broth culture filtrate [2].
  • By contrast, incubation of adenoid tissue with dirithromycin (0.125 to 1.0 microg/ml) for 4 h prior to assembling the organ culture reduced the mucosal damage caused by subsequent H. influenzae infection by as much as 50% [2].
  • Incubation of H. influenzae with dirithromycin at sub-MICs (0.125 and 0.5 microg/ml) prior to infection of the organ cultures did not reduce the mucosal damage caused by bacterial infection [2].

Chemical compound and disease context of AIDS007805


Biological context of AIDS007805


Anatomical context of AIDS007805


Associations of AIDS007805 with other chemical compounds


Gene context of AIDS007805


Analytical, diagnostic and therapeutic context of AIDS007805


  1. Comparison of dirithromycin and penicillin for treatment of streptococcal pharyngitis. Watkins, V.S., Smietana, M., Conforti, P.M., Sides, G.D., Huck, W. Antimicrob. Agents Chemother. (1997) [Pubmed]
  2. Effect of dirithromycin on Haemophilus influenzae infection of the respiratory mucosa. Rutman, A., Dowling, R., Wills, P., Feldman, C., Cole, P.J., Wilson, R. Antimicrob. Agents Chemother. (1998) [Pubmed]
  3. In vitro activity of dirithromycin against Chlamydia trachomatis. Segreti, J., Kapell, K.S. Antimicrob. Agents Chemother. (1994) [Pubmed]
  4. Interactions of dirithromycin with human polymorphonuclear leukocytes. Hand, W.L., Hand, D.L. Antimicrob. Agents Chemother. (1993) [Pubmed]
  5. Pharmacokinetics of dirithromycin in patients with mild or moderate cirrhosis. Mazzei, T., Surrenti, C., Novelli, A., Biagini, M.R., Fallani, S., Cassetta, M.I., Conti, S., Surrenti, E. Antimicrob. Agents Chemother. (1999) [Pubmed]
  6. Safety profile of dirithromycin. Sides, G.D., Conforti, P.M. J. Antimicrob. Chemother. (1993) [Pubmed]
  7. Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides. Hardy, D.J., Hensey, D.M., Beyer, J.M., Vojtko, C., McDonald, E.J., Fernandes, P.B. Antimicrob. Agents Chemother. (1988) [Pubmed]
  8. A comparison of 5 days of dirithromycin and 7 days of clarithromycin in acute bacterial exacerbation of chronic bronchitis. Hosie, J., Quinn, P., Smits, P., Sides, G. J. Antimicrob. Chemother. (1995) [Pubmed]
  9. Clinical efficacy of dirithromycin versus miocamycin in the treatment of acute bronchitis or acute exacerbations of chronic bronchitis. Pozzi, E. J. Antimicrob. Chemother. (1993) [Pubmed]
  10. Development of interpretive criteria and quality control limits for macrolide and clindamycin susceptibility testing of Streptococcus pneumoniae. Jorgensen, J.H., Swenson, J.M., Tenover, F.C., Barry, A., Ferraro, M.J., Murray, P.R., Reller, L.B. J. Clin. Microbiol. (1996) [Pubmed]
  11. Antimicrobial characterization and interrelationships of dirithromycin and epidirithromycin. Kirst, H.A., Creemer, L.C., Paschal, J.W., Preston, D.A., Alborn, W.E., Counter, F.T., Amos, J.G., Clemens, R.L., Sullivan, K.A., Greene, J.M. Antimicrob. Agents Chemother. (1995) [Pubmed]
  12. Tissue distribution of dirithromycin: comparison with erythromycin. Bergogne-Bérézin, E. J. Antimicrob. Chemother. (1993) [Pubmed]
  13. Investigation of the in-vitro uptake, intraphagocytic biological activity and effects on neutrophil superoxide generation of dirithromycin compared with erythromycin. Jooné, G.K., Van Rensburg, C.E., Anderson, R. J. Antimicrob. Chemother. (1992) [Pubmed]
  14. Investigation of dirithromycin and erythromycylamine uptake by human neutrophils in vitro. Mtairag, E.M., Abdelghaffar, H., Labro, M.T. J. Antimicrob. Chemother. (1994) [Pubmed]
  15. The penetration of dirithromycin into bronchoalveolar lavage fluid and alveolar macrophages. Baughman, R.P., DeSante, K.A., Lanier, T.L., Conforti, P.M., Sides, G.D. J. Antimicrob. Chemother. (1994) [Pubmed]
  16. Dirithromycin: a new macrolide. Wintermeyer, S.M., Abdel-Rahman, S.M., Nahata, M.C. The Annals of pharmacotherapy. (1996) [Pubmed]
  17. Dirithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy. Brogden, R.N., Peters, D.H. Drugs (1994) [Pubmed]
  18. Effects of dirithromycin and erythromycylamine on human neutrophil degranulation. Abdelghaffar, H., Mtairag, E.M., Labro, M.T. Antimicrob. Agents Chemother. (1994) [Pubmed]
  19. In-vitro activities of 14-, 15- and 16-membered macrolides against gram-positive cocci. Hamilton-Miller, J.M. J. Antimicrob. Chemother. (1992) [Pubmed]
  20. Lack of effect of dirithromycin on theophylline pharmacokinetics in healthy volunteers. McConnell, S.A., Nafziger, A.N., Amsden, G.W. J. Antimicrob. Chemother. (1999) [Pubmed]
  21. Comparative in vitro evaluation of dirithromycin tested against recent clinical isolates of Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae, including effects of medium supplements and test conditions on MIC results. Biedenbach, D.J., Jones, R.N., Lewis, M.T., Croco, M.A., Barrett, M.S. Diagn. Microbiol. Infect. Dis. (1999) [Pubmed]
  22. In vitro effects of spiramycin and dirithromycin on IL1 beta production by human LPS-stimulated mononuclear cells. Moutard, I., Gressier, B., Bonte, F., Dine, T., Brunet, C., Luyckx, M., Ballester, L., Cazin, M., Cazin, J.C. Thérapie. (1999) [Pubmed]
  23. Cytochrome P-450 complex formation by dirithromycin and other macrolides in rat and human livers. Lindstrom, T.D., Hanssen, B.R., Wrighton, S.A. Antimicrob. Agents Chemother. (1993) [Pubmed]
  24. Pharmacokinetics of dirithromycin. Sides, G.D., Cerimele, B.J., Black, H.R., Busch, U., DeSante, K.A. J. Antimicrob. Chemother. (1993) [Pubmed]
  25. A comparison of 5-day courses of dirithromycin and azithromycin in the treatment of acute exacerbations of chronic obstructive pulmonary disease. Castaldo, R.S., Celli, B.R., Gomez, F., LaVallee, N., Souhrada, J., Hanrahan, J.P. Clinical therapeutics. (2003) [Pubmed]
  26. A study of the interaction between dirithromycin and astemizole in healthy adults. Bachmann, K., Sullivan, T.J., Reese, J.H., Jauregui, L., Miller, K., Scott, M., Stotka, J., Harris, J. American journal of therapeutics. (1997) [Pubmed]
  27. A multicentre study comparing the safety and efficacy of dirithromycin with erythromycin in the treatment of bronchitis. Gaillat, J. J. Antimicrob. Chemother. (1993) [Pubmed]
  28. Clinical efficacy of dirithromycin in pharyngitis and tonsillitis. Müller, O., Wettich, K. J. Antimicrob. Chemother. (1993) [Pubmed]
  29. Five-day dirithromycin therapy is as effective as seven-day erythromycin therapy for acute exacerbations of chronic bronchitis. Wasilewski, M.M., Johns, D., Sides, G.D. J. Antimicrob. Chemother. (1999) [Pubmed]
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