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Chemical Compound Review

norvalin     (2S)-2-aminopentanoic acid

Synonyms: norvaline, NVAL, L-norvaline, L-NVA-OH, h-nva-oh, ...
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Disease relevance of alpha-L-Aminopentanoic acid


High impact information on alpha-L-Aminopentanoic acid


Chemical compound and disease context of alpha-L-Aminopentanoic acid

  • The effects of these amino acids singly or in combinations and the amino acids norleucine and norvaline on the growth of porcine E. coli were studied [9].

Biological context of alpha-L-Aminopentanoic acid


Anatomical context of alpha-L-Aminopentanoic acid


Associations of alpha-L-Aminopentanoic acid with other chemical compounds


Gene context of alpha-L-Aminopentanoic acid


Analytical, diagnostic and therapeutic context of alpha-L-Aminopentanoic acid

  • The presence of the norvaline was confirmed by several analytical methods such as amino acid analysis, peptide mapping, electrospray mass spectrometry, and Edman protein sequencing [1].
  • Behavioral and electrophysiological (EOG) experiments indicated that the difference in relative stimulatory effectiveness levels between NVAL and PRO is > 30,000 times [25].


  1. Incorporation of norvaline at leucine positions in recombinant human hemoglobin expressed in Escherichia coli. Apostol, I., Levine, J., Lippincott, J., Leach, J., Hess, E., Glascock, C.B., Weickert, M.J., Blackmore, R. J. Biol. Chem. (1997) [Pubmed]
  2. Determination of biocatalyst consumption in an aminopeptidase process using automated sample preparation and high-performance liquid chromatography. Duchateau, A.L., Hillemans, M.G., Schepers, C.H., Ketelaar, P.E., Hermes, H.F., Kamphuis, J. J. Chromatogr. (1991) [Pubmed]
  3. Crystallization of Arthrobacter sp. strain 1C N-(1-D-carboxyethyl)-L- norvaline dehydrogenase and its complex with NAD+. Britton, K.L., Rogers, H.F., Asano, Y., Dairi, T., Kato, Y., Stillman, T.J. Acta Crystallogr. D Biol. Crystallogr. (1998) [Pubmed]
  4. Norvaline accumulation by regulatory mutants of Serratia marcescens. Kisumi, M., Sugiura, M., Takagi, T., Chibata, I. J. Antibiot. (1977) [Pubmed]
  5. Properties of some norvaline-resistant mutants of Bacillus subtilis. Holtzclaw, W.D., Chapman, L.F. J. Gen. Microbiol. (1975) [Pubmed]
  6. Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity. Chang, C.I., Liao, J.C., Kuo, L. Cancer Res. (2001) [Pubmed]
  7. The involvement of tyrosine kinases, cyclic AMP/protein kinase A, and p38 mitogen-activated protein kinase in IL-13-mediated arginase I induction in macrophages: its implications in IL-13-inhibited nitric oxide production. Chang, C.I., Zoghi, B., Liao, J.C., Kuo, L. J. Immunol. (2000) [Pubmed]
  8. Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3). Nagase, H., Fields, C.G., Fields, G.B. J. Biol. Chem. (1994) [Pubmed]
  9. Effects of exogenous amino acids on the multiplication of porcine Escherichia coli. Aning, K.G., Thomlinson, J.R. Vet. Microbiol. (1989) [Pubmed]
  10. Properties of crystalline leucine dehydrogenase from Bacillus sphaericus. Ohshima, T., Misono, H., Soda, K. J. Biol. Chem. (1978) [Pubmed]
  11. Purification and catalytic properties of L-valine dehydrogenase from Streptomyces cinnamonensis. Priestley, N.D., Robinson, J.A. Biochem. J. (1989) [Pubmed]
  12. A steady-state random-order mechanism for the oxidative deamination of norvaline by glutamate dehydrogenase. LiMuti, C., Bell, J.E. Biochem. J. (1983) [Pubmed]
  13. Pepstatin analogues as novel renin inhibitors. Guégan, R., Diaz, J., Cazaubon, C., Beaumont, M., Carlet, C., Clément, J., Demarne, H., Mellet, M., Richaud, J.P., Segondy, D. J. Med. Chem. (1986) [Pubmed]
  14. Structure and conformation on linear peptides. VI. Structure of D,L-alanyl-L,D-norvaline. Murali, R., Lalitha, V., Subramanian, E., Parthasarathy, R. Int. J. Pept. Protein Res. (1986) [Pubmed]
  15. Resistance and susceptibility to Marek's disease: nitric oxide synthase/arginase activity balance. Djeraba, A., Musset, E., van Rooijen, N., Quéré, P. Vet. Microbiol. (2002) [Pubmed]
  16. Two novel thioamide analogues of TRH with selective activity on CNS. Alexandrová, M., Strbák, V., Kruszynski, M., Zboinska, J., Kupryszewski, G. Gen. Physiol. Biophys. (1991) [Pubmed]
  17. Substrate specificity and protonation state of ornithine transcarbamoylase as determined by pH studies. Kuo, L.C., Herzberg, W., Lipscomb, W.N. Biochemistry (1985) [Pubmed]
  18. Thymic selection is influenced by subtle structural variation involving the p4 residue of an MHC class I-bound peptide. Sasada, T., Ghendler, Y., Wang, J.H., Reinherz, E.L. Eur. J. Immunol. (2000) [Pubmed]
  19. Changes in the ornithine cycle following ionising radiation cause a cytotoxic conditioning of the culture medium of H35 hepatoma cells. van Rijn, J., van den Berg, J., Teerlink, T., Kruyt, F.A., Schor, D.S., Renardel de Lavalette, A.C., van den Berg, T.K., Jakobs, C., Slotman, B.J. Br. J. Cancer (2003) [Pubmed]
  20. Persistent excitability changes in the piriform cortex of the isolated guinea-pig brain after transient exposure to bicuculline. Forti, M., Biella, G., Caccia, S., de Curtis, M. Eur. J. Neurosci. (1997) [Pubmed]
  21. Crystal structure of human ornithine transcarbamylase complexed with carbamoyl phosphate and L-norvaline at 1.9 A resolution. Shi, D., Morizono, H., Aoyagi, M., Tuchman, M., Allewell, N.M. Proteins (2000) [Pubmed]
  22. The effects of various inhibitors on the regulation of orotic acid excretion in sparse-fur mutant mice (spf/Y) deficient in ornithine transcarbamylase. Nelson, J., Qureshi, I.A., Vasudevan, S., Sarma, D.S. Chem. Biol. Interact. (1993) [Pubmed]
  23. DL-2-amino-5-phosphonopentanoic acid, a specific N-methyl-D-aspartic acid receptor antagonist, suppresses pulsatile LH release in the rat. Arslan, M., Pohl, C.R., Plant, T.M. Neuroendocrinology (1988) [Pubmed]
  24. Arginine deprivation and tumour cell death: arginase and its inhibition. Wheatley, D.N., Philip, R., Campbell, E. Mol. Cell. Biochem. (2003) [Pubmed]
  25. Learned olfactory discrimination of amino acids and their binary mixtures in bullhead catfish (Ameiurus nebulosus). Valentincic, T., Kralj, J., Stenovec, M., Koce, A. Pflugers Arch. (1996) [Pubmed]
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