The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Selbelle     (5E,9E,13E)-6,10,14,18- tetramethylnonadeca...

Synonyms: teprenon, Teprenona, teprenone, Selbex, Teprenonum, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Geranylgeranyl acetone

 

Psychiatry related information on Geranylgeranyl acetone

 

High impact information on Geranylgeranyl acetone

 

Chemical compound and disease context of Geranylgeranyl acetone

 

Biological context of Geranylgeranyl acetone

 

Anatomical context of Geranylgeranyl acetone

 

Associations of Geranylgeranyl acetone with other chemical compounds

 

Gene context of Geranylgeranyl acetone

  • CONCLUSIONS: These results suggest HSP72 plays a novel role in antagonizing delayed cerebral vasospasm after SAH and that GGA provides protective effects against delayed cerebral vasospasm, at least partly via induction of HSP72 [24].
  • We recently demonstrated that oral administration of geranylgeranylacetone (GGA), an antiulcer agent, induces heat-shock protein 72 (HSP72) in the rat heart and renders cardioprotection against ischemia/reperfusion injury [25].
  • Pre-administration of teprenone (200 mg kg-1) prevented the decrease in gastric mucosal cNOS activity with attenuations of neutrophil infiltration into gastric mucosal tissues and decreased levels of gastric mucosal hexosamine, an index of gastric mucin, and adherent mucus in rats with 3 or 6 h of WIR stress [26].
  • We report here a new TRX inducer substance, geranylgeranylacetone (GGA), which is originally derived from a natural plant constituent and has been used in the clinical field as an anti-ulcer drug [27].
  • We will discuss a possible novel molecular mechanism of GGA, which is to protect cells via the induction of TRX and activation of transcription factors such as NF-kappa B and AP-1 [27].
 

Analytical, diagnostic and therapeutic context of Geranylgeranyl acetone

References

  1. Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70. Suzuki, S., Maruyama, S., Sato, W., Morita, Y., Sato, F., Miki, Y., Kato, S., Katsuno, M., Sobue, G., Yuzawa, Y., Matsuo, S. Kidney Int. (2005) [Pubmed]
  2. Antiviral effects of geranylgeranylacetone: enhancement of MxA expression and phosphorylation of PKR during influenza virus infection. Unoshima, M., Iwasaka, H., Eto, J., Takita-Sonoda, Y., Noguchi, T., Nishizono, A. Antimicrob. Agents Chemother. (2003) [Pubmed]
  3. Role of protein kinase C in neuroprotective effect of geranylgeranylacetone, a noninvasive inducing agent of heat shock protein, on delayed neuronal death caused by transient ischemia in rats. Fujiki, M., Hikawa, T., Abe, T., Uchida, S., Morishige, M., Sugita, K., Kobayashi, H. J. Neurotrauma (2006) [Pubmed]
  4. Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons. Kikuchi, S., Shinpo, K., Takeuchi, M., Tsuji, S., Yabe, I., Niino, M., Tashiro, K. J. Neurosci. Res. (2002) [Pubmed]
  5. Geranylgeranylacetone, an inducer of HSP 70, attenuates REM sleep rebound after sleep deprivation. Wada, T., Sei, H., Kusumoto, K., Kitaoka, K., Chikahisa, S., Rokutan, K., Morita, Y. Brain Res. Bull. (2006) [Pubmed]
  6. Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Hirakawa, T., Rokutan, K., Nikawa, T., Kishi, K. Gastroenterology (1996) [Pubmed]
  7. Geranylgeranylacetone protects membranes against nonsteroidal anti-inflammatory drugs. Ushijima, H., Tanaka, K., Takeda, M., Katsu, T., Mima, S., Mizushima, T. Mol. Pharmacol. (2005) [Pubmed]
  8. An anti-ulcer drug, geranylgeranylacetone, suppresses inducible nitric oxide synthase in cultured vascular smooth muscle cells. Yamamoto, K., Sarukawa, M., Ito, T., Aoki, H., Ichida, M., Shimada, K. J. Hypertens. (2005) [Pubmed]
  9. Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model. Ishii, Y., Kwong, J.M., Caprioli, J. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  10. A non-toxic heat shock protein 70 inducer, geranylgeranylacetone, suppresses apoptosis of cultured rat hepatocytes caused by hydrogen peroxide and ethanol. Ikeyama, S., Kusumoto, K., Miyake, H., Rokutan, K., Tashiro, S. J. Hepatol. (2001) [Pubmed]
  11. Teprenone, but not H2-receptor blocker or sucralfate, suppresses corpus Helicobacter pylori colonization and gastritis in humans: teprenone inhibition of H. pylori-induced interleukin-8 in MKN28 gastric epithelial cell lines. Miyake, K., Tsukui, T., Shinji, Y., Shinoki, K., Hiratsuka, T., Nishigaki, H., Futagami, S., Wada, K., Gudis, K., Iwakiri, K., Yamada, N., Sakamoto, C. Helicobacter (2004) [Pubmed]
  12. Protective effect of geranylgeranylacetone on trinitrobenzene sulfonic acid-induced colitis in mice. Ohkawara, T., Nishihira, J., Takeda, H., Katsurada, T., Kato, K., Yoshiki, T., Sugiyama, T., Asaka, M. Int. J. Mol. Med. (2006) [Pubmed]
  13. Proposed mechanism for induction of heat shock protein 70 by geranylgeranyl acetone by prenylation of Ras proteins. Bar-Or, D. Crit. Care Med. (2003) [Pubmed]
  14. Astroglial activation accompanies heat shock protein upregulation in rat brain following single oral dose of geranylgeranylacetone. Fujiki, M., Kobayashi, H., Abe, T., Ishii, K. Brain Res. (2003) [Pubmed]
  15. Preventive effect of teprenone on acute gastric mucosal lesion progression in compound 48/80-treated rats. Ohta, Y., Kobayashi, T., Inui, K., Yoshino, J., Kitagawa, A., Nakazawa, S. Eur. J. Pharmacol. (2004) [Pubmed]
  16. Geranylgeranylacetone induces antiviral gene expression in human hepatoma cells. Ichikawa, T., Nakao, K., Nakata, K., Hamasaki, K., Takeda, Y., Kajiya, Y., Higashi, S., Ohkubo, K., Kato, Y., Ishii, N., Eguchi, K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  17. Suppression of ethanol-induced apoptotic DNA fragmentation by geranylgeranylacetone in cultured guinea pig gastric mucosal cells. Mizushima, T., Tsutsumi, S., Rokutan, K., Tsuchiya, T. Dig. Dis. Sci. (1999) [Pubmed]
  18. Geranylgeranylacetone protects human monocytes from mitochondrial membrane depolarization independently of Hsp70 expression. Aron, Y., Vayssier-Taussat, M., Bachelet, M., Polla, B.S. Cell. Mol. Life Sci. (2001) [Pubmed]
  19. Effects of taurocholic acid/HCl alone or after pretreatment with geranylgeranylacetone on phospholipid metabolism in rat gastric mucosa. Nishizawa, Y., Sakurai, H., Oketani, K., Horie, T., Yamato, C., Moriga, M. Biochem. Pharmacol. (1987) [Pubmed]
  20. Geranylgeranylacetone, a novel anti-ulcer drug, stimulates mucus synthesis and secretion in rat gastric cultured cells. Terano, A., Hiraishi, H., Ota, S., Sugimoto, T. Digestion (1986) [Pubmed]
  21. Increase in hepatic tissue blood flow by teprenone. Kurihara, T., Kitamura, Y., Adachi, Y., Obuchi, M., Abe, K., Akimoto, M., Hashimoto, H., Ishiguro, H., Niimi, A., Maeda, A., Shigemoto, M., Yamashita, K., Yokoyama, I. J. Gastroenterol. Hepatol. (1996) [Pubmed]
  22. Effect of geranylgeranylacetone on gentamycin ototoxicity in rat cochlea culture. Sano, H., Yoneda, S., Iwase, H., Itoh, A., Hashimoto, D., Okamoto, M. Auris, nasus, larynx (2007) [Pubmed]
  23. Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues. Kobayashi, T., Ohta, Y., Yoshino, J., Nakazawa, S. Pharmacol. Res. (2001) [Pubmed]
  24. Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage. Nikaido, H., Tsunoda, H., Nishimura, Y., Kirino, T., Tanaka, T. Circulation (2004) [Pubmed]
  25. Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart. Yamanaka, K., Takahashi, N., Ooie, T., Kaneda, K., Yoshimatsu, H., Saikawa, T. J. Mol. Cell. Cardiol. (2003) [Pubmed]
  26. Preventive effect of teprenone on stress-induced gastric mucosal lesions and its relation to gastric mucosal constitutive nitric oxide synthase activity. Nishida, K., Ohta, Y., Ishiguro, I. Pharmacol. Res. (1999) [Pubmed]
  27. Thioredoxin superfamily and thioredoxin-inducing agents. Hirota, K., Nakamura, H., Masutani, H., Yodoi, J. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  28. Geranylgeranylacetone, a heat shock protein inducer, prevents primary graft nonfunction in rat liver transplantation. Fudaba, Y., Ohdan, H., Tashiro, H., Ito, H., Fukuda, Y., Dohi, K., Asahara, T. Transplantation (2001) [Pubmed]
  29. Clinical evaluation of teprenone, a mucosal protective agent, in the treatment of patients with gastric ulcers: a nationwide, multicenter clinical study. Shirakabe, H., Takemoto, T., Kobayashi, K., Ogoshi, K., Kimura, K., Nakamura, K., Watanabe, H. Clinical therapeutics. (1995) [Pubmed]
  30. Oral administration of geranylgeranylacetone blunts the endothelial dysfunction induced by ischemia and reperfusion in the rat heart. Zhu, Z., Takahashi, N., Ooie, T., Shinohara, T., Yamanaka, K., Saikawa, T. J. Cardiovasc. Pharmacol. (2005) [Pubmed]
  31. Geranylgeranylacetone suppresses inflammatory responses and improves survival after massive hepatectomy in rats. Oda, H., Miyake, H., Iwata, T., Kusumoto, K., Rokutan, K., Tashiro, S. J. Gastrointest. Surg. (2002) [Pubmed]
  32. Effect of teprenone on portal hypertensive gastric mucosa. Tanoue, K., Tarnawski, A.S., Kishihara, F., Ohta, M., Hashizume, M., Sugimachi, K., Sarfeh, I.J. Digestion (1996) [Pubmed]
 
WikiGenes - Universities