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Chemical Compound Review

KST-1B0030     [[[5-(2,4-dioxopyrimidin-1- yl)-3-hydroxy...

Synonyms: AR-1B9079, AC1L19ST, AC1Q6S3U
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Disease relevance of deoxy-UTP


High impact information on deoxy-UTP

  • Furthermore, sigma1 protein in the SED was associated with fragmented DNA by terminal deoxy-UTP nick-end labeling staining, activated caspase-3, and the epithelial cell protein cytokeratin, suggesting that DCs capture T1L antigen from infected apoptotic epithelial cells [2].
  • A 2-fold increase in the number of terminal deoxynucleotidyl transferase-mediated deoxy-UTP nick end labeling-positive nuclei was detected in h-IAPP-treated human islets (P < 0.001) [3].
  • An in situ terminal-deoxynucleotidyl transferase-mediated deoxy-UTP nick end-labeling (TUNEL) assay characterized germ cell apoptosis [4].
  • Apoptosis was assessed by the terminal deoxynucleotidyl transferase-mediated deoxy-UTP nick endlabeling method, using a monoclonal antibody recognizing areas of DNA fragmentation [5].
  • The apoptotic index (percentage of terminal deoxynucleotidyl transferase deoxy-UTP-nick end labeling-positive nuclei of the total nuclei) ranged from 8-29% in amnion epithelial, chorionic trophoblast, and decidual cell layers from women at 23-30, 31-36, and 37-42 weeks gestation [6].

Biological context of deoxy-UTP


Anatomical context of deoxy-UTP

  • Using the terminal deoxynucleotidyl transferase deoxy-UTP-nick end labeling immunohistochemical technique, apoptotic nuclei were identified in amnion epithelial, chorionic trophoblast, and decidua parietalis cell layers of human fetal membranes at term [6].
  • In situ terminal deoxynucleotidyltransferase-mediated deoxy-UTP nick end labeling revealed that spermatocytes represented the predominant apoptotic cell type [9].
  • Terminal deoxynucleotidyl transferase- mediated deoxyuridine triphosphate (dUTP) labeling of apoptotic nuclei showed that apoptotic inflammatory cells increase in concentration within necrotic fibers and in the connective tissue at 2 days following muscle injury caused by increased loading [10].
  • Terminal deoxynucleotidyl transferase-mediated deoxy-UTP nick end-labeling assays showed a high frequency of apoptosis in the ric1 embryos immediately after gamma-irradiation at the pre-early gastrula stage but apoptotic cells were not observed before midblastula transition (MBT) [11].
  • Terminal deoxy-UTP nick end labeling and PRL-immunostaining revealed an abundance of apoptotic nuclei in both cephalic and caudal lobes of the anterior pituitary gland, suggestive of programmed cellular death of lactotrophs in the pituitary gland of hens nest-deprived for 2 or more days [12].

Associations of deoxy-UTP with other chemical compounds


Gene context of deoxy-UTP


Analytical, diagnostic and therapeutic context of deoxy-UTP


  1. Apoptosis as an independent prognostic indicator in squamous cell carcinoma of the esophagus. Shibata, H., Matsubara, O. Pathol. Int. (2001) [Pubmed]
  2. Peyer's patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice. Fleeton, M.N., Contractor, N., Leon, F., Wetzel, J.D., Dermody, T.S., Kelsall, B.L. J. Exp. Med. (2004) [Pubmed]
  3. Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway. Lin, C.Y., Gurlo, T., Haataja, L., Hsueh, W.A., Butler, P.C. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  4. HST-1/FGF-4 protects male germ cells from apoptosis under heat-stress condition. Hirai, K., Sasaki, H., Yamamoto, H., Sakamoto, H., Kubota, Y., Kakizoe, T., Terada, M., Ochiya, T. Exp. Cell Res. (2004) [Pubmed]
  5. Effects of octreotide treatment on the proliferation and apoptotic index of GH-secreting pituitary adenomas. Losa, M., Ciccarelli, E., Mortini, P., Barzaghi, R., Gaia, D., Faccani, G., Papotti, M., Mangili, F., Terreni, M.R., Camanni, F., Giovanelli, M. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  6. Apoptosis and Fas expression in human fetal membranes. Runić, R., Lockwood, C.J., LaChapelle, L., Dipasquale, B., Demopoulos, R.I., Kumar, A., Guller, S. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  7. Targeted disruption of the IGF-I receptor gene decreases cellular proliferation in mammary terminal end buds. Bonnette, S.G., Hadsell, D.L. Endocrinology (2001) [Pubmed]
  8. Macrophage and myofibroblast involvement in ischemic acute renal failure is attenuated by endothelin receptor antagonists. Forbes, J.M., Leaker, B., Hewitson, T.D., Becker, G.J., Jones, C.L. Kidney Int. (1999) [Pubmed]
  9. Caspase-3 and caspase-activated deoxyribonuclease are associated with testicular germ cell apoptosis resulting from reduced intratesticular testosterone. Kim, J.M., Ghosh, S.R., Weil, A.C., Zirkin, B.R. Endocrinology (2001) [Pubmed]
  10. Apoptosis of macrophages during the resulution of muscle inflammation. Tidball, J.G., St Pierre, B.A. J. Leukoc. Biol. (1996) [Pubmed]
  11. Identification of radiation-sensitive mutants in the Medaka, Oryzias latipes. Aizawa, K., Mitani, H., Kogure, N., Shimada, A., Hirose, Y., Sasado, T., Morinaga, C., Yasuoka, A., Yoda, H., Watanabe, T., Iwanami, N., Kunimatsu, S., Osakada, M., Suwa, H., Niwa, K., Deguchi, T., Hennrich, T., Todo, T., Shima, A., Kondoh, H., Furutani-Seiki, M. Mech. Dev. (2004) [Pubmed]
  12. Increased proliferative activity and programmed cellular death in the turkey hen pituitary gland following interruption of incubation behavior. Ramesh, R., Kuenzel, W.J., Proudman, J.A. Biol. Reprod. (2001) [Pubmed]
  13. Thyrotropin prevents apoptosis by promoting cell adhesion and cell cycle progression in FRTL-5 cells. Li, X., Lu, S., Miyagi, E., Katoh, R., Kawaoi, A. Endocrinology (1999) [Pubmed]
  14. Evidence for apoptosis correlated with mortality in the giant black tiger shrimp Penaeus monodon infected with yellow head virus. Khanobdee, K., Soowannayan, C., Flegel, T.W., Ubol, S., Withyachumnarnkul, B. Dis. Aquat. Org. (2002) [Pubmed]
  15. Nonradioactive in situ hybridization with digoxigenin labeled DNA probes. Arnold, N., Seibl, R., Kessler, C., Wienberg, J. Biotechnic & histochemistry : official publication of the Biological Stain Commission. (1992) [Pubmed]
  16. Cell proliferation, apoptosis, angiogenesis and growth rate of incidentally found renal cell carcinoma. Oda, T., Takahashi, A., Miyao, N., Yanase, M., Masumori, N., Itoh, N., Sato, M.A., Kon, S., Tsukamoto, T. International journal of urology : official journal of the Japanese Urological Association. (2003) [Pubmed]
  17. Sensitivity of testicular germ cells to toxicant-induced apoptosis in gld mice that express a nonfunctional form of Fas ligand. Richburg, J.H., Nañez, A., Williams, L.R., Embree, M.E., Boekelheide, K. Endocrinology (2000) [Pubmed]
  18. Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis. Cooksey, R.C., Jouihan, H.A., Ajioka, R.S., Hazel, M.W., Jones, D.L., Kushner, J.P., McClain, D.A. Endocrinology (2004) [Pubmed]
  19. Apoptosis in congestive heart failure induced by viral myocarditis in mice. Yamada, T., Matsumori, A., Wang, W.Z., Ohashi, N., Shiota, K., Sasayama, S. Heart and vessels. (1999) [Pubmed]
  20. Diabetes alters the response to bacteria by enhancing fibroblast apoptosis. Liu, R., Desta, T., He, H., Graves, D.T. Endocrinology (2004) [Pubmed]
  21. Increased and persistent circulating insulin-like growth factor II in neonatal transgenic mice suppresses developmental apoptosis in the pancreatic islets. Hill, D.J., Strutt, B., Arany, E., Zaina, S., Coukell, S., Graham, C.F. Endocrinology (2000) [Pubmed]
  22. Effect of early fetal splenectomy on prenatal B-cell development in sheep. Press, C.M., McCullagh, P., Landsverk, T. Immunology (2001) [Pubmed]
  23. Involvement of Fas system and active caspases in apoptotic signalling in testicular germ cells of ethanol-treated rats. Eid, N.A., Shibata, M.A., Ito, Y., Kusakabe, K., Hammad, H., Otsuki, Y. Int. J. Androl. (2002) [Pubmed]
  24. Prevention of carryover contamination in the detection of beta S and beta C genes by polymerase chain reaction. Wang, X., Chen, T., Kim, D., Piomelli, S. Am. J. Hematol. (1992) [Pubmed]
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