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Chemical Compound Review

Alfadolone     (3R,5S,9S,14S)-3-hydroxy-17- (2...

Synonyms: Alphadolone, LS-118542, FT-0661527, AC1L2GM0, GR 2/1574, ...
 
 
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Disease relevance of Alfadolone

 

High impact information on Alfadolone

 

Biological context of Alfadolone

 

Anatomical context of Alfadolone

 

Associations of Alfadolone with other chemical compounds

 

Gene context of Alfadolone

  • Both Alfx and Alfd bind to TeBG and CBG with a relatively high affinity (10(6)M-1) [19].

References

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  2. Neurones in the medullary raphe nuclei attenuate the cardiovascular responses evoked from the dorsolateral periaqueductal grey matter. Schenberg, L.C., Lovick, T.A. Brain Res. (1994) [Pubmed]
  3. Antinociceptive properties of neurosteroids IV: pilot study demonstrating the analgesic effects of alphadolone administered orally to humans. Goodchild, C.S., Robinson, A., Nadeson, R. British journal of anaesthesia. (2001) [Pubmed]
  4. Althesin and pancuronium in chronic liver disease. Ward, M.E., Adu-Gyamfi, Y., Strunin, L. British journal of anaesthesia. (1975) [Pubmed]
  5. Seizure duration in unilateral electroconvulsive therapy. A comparison of the anaesthetic agents etomidate and Althesin with methohexitone. Gran, L., Bergsholm, P., Bleie, H. Acta psychiatrica Scandinavica. (1984) [Pubmed]
  6. Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA(A) receptors. Nadeson, R., Goodchild, C.S. Pain (2000) [Pubmed]
  7. Facilitation of synaptic transmission by general anaesthetics. Morris, M.E. J. Physiol. (Lond.) (1978) [Pubmed]
  8. Involvement of nitric oxide and serotonin in modulation of antinociception and pressor responses evoked by stimulation in the dorsolateral region of the periaqueductal gray matter in the rat. Hämäläinen, M.M., Lovick, T.A. Neuroscience (1997) [Pubmed]
  9. Pressure reversal of alphaxalone/alphadolone and methohexitone in tadpoles: evidence for different molecular sites for general anaesthesia. Halsey, M.J., Wardley-Smith, B., Wood, S. Br. J. Pharmacol. (1986) [Pubmed]
  10. Porphyrin-inducing activity of alfaxolone and alfadolone acetate in chick embryo liver cells. Fischer, P.W., Ferizovic, A., Neilson, I.R., Marks, G.S. Anesthesiology (1979) [Pubmed]
  11. Modulation of the cardiovascular defence response by low frequency stimulation of a deep somatic nerve in rats. Lovick, T.A., Li, P., Schenberg, L.C. J. Auton. Nerv. Syst. (1995) [Pubmed]
  12. Inhibitory effects evoked from both the lateral and ventrolateral periaqueductal grey are selective for the nociceptive responses of rat dorsal horn neurones. Waters, A.J., Lumb, B.M. Brain Res. (1997) [Pubmed]
  13. Intra-patient comparison of the kinetics of alphaxalone and alphadolone in man. Sear, J.W., Sanders, R.S. European journal of anaesthesiology. (1984) [Pubmed]
  14. Inhibitory modulation of the cardiovascular defence response by the ventrolateral periaqueductal grey matter in rats. Lovick, T.A. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1992) [Pubmed]
  15. Comparison of the effects of Althesin and sodium pentobarbitone on the regional uptake of 2-deoxyglucose by the brain and pituitary gland of the rat: selective effects on pars intermedia. McQueen, J.K., Martin, M.J., Fink, G. Neuroendocrinology (1984) [Pubmed]
  16. Role of nitric oxide and serotonin in modulation of the cardiovascular defence response evoked by stimulation in the periaqueductal grey matter in rats. Hamalainen, M.M., Lovick, T.A. Neurosci. Lett. (1997) [Pubmed]
  17. Inhibitory effects of steroidal anesthetics on histamine release from rat mast cells stimulated by concanavalin A, compound 48/80 and A23187. Suzuki, T., Tomioka, M., Uchida, M.K. Gen. Pharmacol. (1988) [Pubmed]
  18. Ostrich anaesthesia: xylazine premedication followed by alphaxalone/alphadolone and isoflurane. Cullen, L.K., Goerke, M.A., Swan, R.A., Clark, W.T., Nandapi, D., Colbourne, C. Aust. Vet. J. (1995) [Pubmed]
  19. Althesin interaction with human plasma steroid binding globulins. Perrot, D., Pugeat, M., Bonneton, A., Mounier-Kuhn, A., Motin, J., Forest, M.G. Eur. J. Clin. Pharmacol. (1985) [Pubmed]
 
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