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Chemical Compound Review

Xylenol orange     2-[[5-[9-[3- [(bis(carboxymethyl)amino) meth...

Synonyms: BIX1004, NSC-324982, AC1Q5WIQ, NSC324982, FT-0633703, ...
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Disease relevance of o-Cresolphthalexon S


High impact information on o-Cresolphthalexon S

  • Three fluorescent markers were used: (1) pOBCol3.6GFP, which is activated in preosteoblastic cells; (2) pOBCol2.3GFP, which is restricted to differentiated osteoblasts; and (3) xylenol orange (XO), which stains the mineralized nodules [2].
  • Quantitative analysis showed that transient PTH first decreased then later increased areas of GFP expression and XO staining, which correlated with results of Northern blot and alkaline phosphatase activity [2].
  • A significant correlation (r = 0.88, p < 0.005) existed between the xylenol orange method of estimating lipid peroxidation and the conventional TBARS assay in a series of animal tissues tested [3].
  • The potential usefulness of the xylenol orange assay for comparative biochemical and toxicological studies of oxidative stress is discussed [3].
  • Total antioxidant capacity (TAC) was determined by enhanced chemiluminescence and lipid hydroperoxides by the ferrous oxidation of Xylenol Orange method [4].

Biological context of o-Cresolphthalexon S


Anatomical context of o-Cresolphthalexon S

  • A sensitive spectrometric assay for assessing iron oxidation and complex formation with xylenol orange (FOX assay) also was used to document in vitro-enhanced H2O2-mediated oxidations by hemolymph from immune-competent larvae [8].
  • In the absence of data on the dynamics of cementum apposition, one female Macaca fascicularis monkey, born July 1984 and sacrificed July 1985, was sequentially injected with calcein and xylenol orange 10 times, about every 33 days [9].

Associations of o-Cresolphthalexon S with other chemical compounds


Gene context of o-Cresolphthalexon S

  • Fasting plasma vWF and LOOH were measured by an inhouse enzyme-linked immunoassay and ferrous oxidation with xylenol orange (FOX) assay, respectively [15].
  • The imaging system, with white light illumination and CCD camera detection, was designed for measurement of the radiation-induced optical density changes in iron- and xylenol orange dye-doped agarose gels [16].
  • The linear concentrations were 0.09-12.00 mE/L for DMPDA, ABTS, APC, and HBSA and 0.09-6.00 mE/L for XO and HIQSA [17].
  • Hydroperoxides were determined by the FOX II assay (ferrous oxidation in xylenol orange, Pierce Rockford, IL) [18].
  • Binding of xylenol orange to transferrin. Demonstration of metal-anion linkage [19].

Analytical, diagnostic and therapeutic context of o-Cresolphthalexon S


  1. Estrogen induces bone formation on non-resorptive surfaces in the rat. Lean, J.M., Chow, J.W., Chambers, T.J. Bone (1993) [Pubmed]
  2. Comparison of the action of transient and continuous PTH on primary osteoblast cultures expressing differentiation stage-specific GFP. Wang, Y.H., Liu, Y., Buhl, K., Rowe, D.W. J. Bone Miner. Res. (2005) [Pubmed]
  3. Quantification of lipid peroxidation in tissue extracts based on Fe(III)xylenol orange complex formation. Hermes-Lima, M., Willmore, W.G., Storey, K.B. Free Radic. Biol. Med. (1995) [Pubmed]
  4. Changes in plasma lipids and markers of oxidative stress in normal pregnancy and pregnancies complicated by diabetes. Toescu, V., Nuttall, S.L., Martin, U., Nightingale, P., Kendall, M.J., Brydon, P., Dunne, F. Clin. Sci. (2004) [Pubmed]
  5. Two distinct cell sources of H2O2 in the lignifying Zinnia elegans cell culture system. Gómez Ros, L.V., Paradiso, A., Gabaldón, C., Pedreño, M.A., de Gara, L., Ros Barceló, A. Protoplasma (2006) [Pubmed]
  6. Tendon healing in a bone tunnel. Part II: Histologic analysis after biodegradable interference fit fixation in a model of anterior cruciate ligament reconstruction in sheep. Weiler, A., Hoffmann, R.F., Bail, H.J., Rehm, O., Südkamp, N.P. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. (2002) [Pubmed]
  7. The use of decalcified granulated homologous cortical bone matrix in the correction of diaphyseal bone defect. An experimental study in rabbits. Volpon, J.B., Xavier, C.A., Conçalves, R.P. Archives of orthopaedic and traumatic surgery. Archiv für orthopädische und Unfall-Chirurgie. (1982) [Pubmed]
  8. Hydrogen peroxide production in immune-reactive Drosophila melanogaster. Nappi, A.J., Vass, E. J. Parasitol. (1998) [Pubmed]
  9. Rate and growth pattern of cementum apposition as compared to dentine and root formation in a fluorochrome-labelled monkey (Macaca fascicularis). Bosshardt, D., Luder, H.U., Schroeder, H.E. Journal de biologie buccale. (1989) [Pubmed]
  10. Sequential labelling of microdamage in bone using chelating agents. Lee, T.C., Arthur, T.L., Gibson, L.J., Hayes, W.C. J. Orthop. Res. (2000) [Pubmed]
  11. Ovariectomy-induced changes in aged beagles: histomorphometry of rib cortical bone. Wilson, A.K., Bhattacharyya, M.H., Miller, S., Mani, A., Sacco-Gibson, N. Calcif. Tissue Int. (1998) [Pubmed]
  12. In the presence of ferritin, visible light induces lipid peroxidation of the porcine photoreceptor outer segment. Ohishi, K., Zhang, X.M., Moriwaki, S., Hiramitsu, T., Matsugo, S. Free Radic. Res. (2006) [Pubmed]
  13. Determination of iron in solutions with the ferric-xylenol orange complex. Gay, C., Collins, J., Gebicki, J.M. Anal. Biochem. (1999) [Pubmed]
  14. Specificity of the ferrous oxidation of xylenol orange assay: analysis of autoxidation products of cholesteryl arachidonate. Yin, H., Porter, N.A. Anal. Biochem. (2003) [Pubmed]
  15. Lipid hydroperoxide and markers of renal disease susceptibility in African-Caribbean and Caucasian patients with Type 2 diabetes mellitus. Mehrotra, S., Ling, K.L., Bekele, Y., Gerbino, E., Earle, K.A. Diabet. Med. (2001) [Pubmed]
  16. Development of a CCD array imaging system for measurement of dose distributions in doped agarose gels. Tarte, B.J., Jardine, P.A., van Doorn, T., Nitschke, K.N., Poulsen, M.G. Medical physics. (1997) [Pubmed]
  17. Six spectroscopic methods for detection of oxidants in urine: implication in differentiation of normal and adulterated urine. Paul, B.D. Journal of analytical toxicology. (2004) [Pubmed]
  18. Prospective evaluation of hydroperoxide plasma levels and stable nitric oxide end products in patients subjected to angioplasty for coronary artery disease. Wykretowicz, A., Dziarmaga, M., Szczepanik, A., Guzik, P., Wysocki, H. International journal of cardiology. (2003) [Pubmed]
  19. Binding of xylenol orange to transferrin. Demonstration of metal-anion linkage. Harris, D.C., Gelb, M.H. Biochim. Biophys. Acta (1980) [Pubmed]
  20. High pressure pulsatile lavage irrigation of intraarticular fractures: effects on fracture healing. Dirschl, D.R., Duff, G.P., Dahners, L.E., Edin, M., Rahn, B.A., Miclau, T. Journal of orthopaedic trauma. (1998) [Pubmed]
  21. Analysis of selected diphosphonic acid derivatives used in treatment of osteoporosis. Part I. Complexometric determination of diphosphonic acid derivatives. Podolska, M., Białecka, W., Kwiatkowska-Puchniarz, B., Tuszyńska, E. Acta poloniae pharmaceutica. (1997) [Pubmed]
  22. Experimental determination of the diffusion coefficient in two-dimensions in ferrous sulphate gels using the finite element method. Baldock, C., Harris, P.J., Piercy, A.R., Healy, B. Australasian physical & engineering sciences in medicine / supported by the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine. (2001) [Pubmed]
  23. Additive effects of prostaglandin E2 and pulsed electromagnetic fields on fracture healing. Tsai, C.L., Chang, W.H., Liu, T.K., Wu, K.H. The Chinese journal of physiology. (1991) [Pubmed]
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