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Chemical Compound Review

SureCN22363     2,6-dimethyl-4-[2-methyl-3- (4-tert...

Synonyms: AGN-PC-00H3Q3, AG-H-74395, AG-L-65650, CHEBI:50148, AC1L3MLV, ...
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Disease relevance of Mistral

  • Although Coxiella burnetii transmission is multifactorial, we may speculate that the high endemicity in the study area is related to a contamination by aerosols because the Mistral blows through the local steppe where 70,000 sheep are bred [1].
  • Sequential high dose chemotherapy as initial treatment for aggressive sub-types of Non-Hodgkin Lymphoma: results of the international randomized phase III trial (MISTRAL) [2].
  • The toxicity of fenpropimorph and seven newly synthesized analogues against Saccharomyces cerevisiae has been determined in liquid media [3].
  • The mistral valve thus was insufficient (a "flail valve''); this markedly reduced the ejection fraction of the left ventricle, increased its end-diastolic volume and pressure, produced a damming of blood in the pulmonary circulation, and this resulted in the pulmonary edema seen on the chest x-ray.(ABSTRACT TRUNCATED AT 250 WORDS)[4]
  • Routine use of open mitral commissurotomy in all cases of rheumatic mistral stenosis is the recommended treatment of choice in recent years [5].

High impact information on Mistral


Biological context of Mistral

  • The resistance to fenpropimorph involves two recessive genes, each of which allows a semiresistance, when they are isolated apart from one another [10].
  • Together with an absence of gene dosage effect for ERG2 on fenpropimorph sensitivity, this supports the hypothesis that sterol delta 8-->7-isomerase inhibition does not contribute to the fungicidal activity of fenpropimorph [11].
  • The most significant advances in the field of Brucella classification since the last meeting have been in the field of Brucella phages reviewed by Corbel & Morgan (1980) Handbuch der Bakteriellen Infektionen bei Tieren, 4, Ed Blobel & Schliesser) and Corbel & Morgan (Bergey's Manual of Determinative Bacteriology [12].

Anatomical context of Mistral


Associations of Mistral with other chemical compounds


Gene context of Mistral

  • Strain JR4 (erg3 erg11), which produces 14-methylfecosterol [14 alpha-methyl-ergosta-8,24(28)-dien- 3-beta-ol) as the major sterol in the presence or absence of fenpropimorph, was also found to be resistant to the drug [10].

Analytical, diagnostic and therapeutic context of Mistral


  1. Hyperendemic focus of Q fever related to sheep and wind. Tissot-Dupont, H., Torres, S., Nezri, M., Raoult, D. Am. J. Epidemiol. (1999) [Pubmed]
  2. Sequential high dose chemotherapy as initial treatment for aggressive sub-types of Non-Hodgkin Lymphoma: results of the international randomized phase III trial (MISTRAL). Betticher, D., Martinelli, G., Radford, J., Kaufmann, M., Dyer, M., Kaiser, U., Aulitzky, W., Beck, J., von Rohr, A., Kovascovics, T., Cogliatti, S., Cina, S., Maibach, R., Cerny, T., Linch, D. Ann. Oncol. (2006) [Pubmed]
  3. Influence of new fenpropimorph fungicides on the growth and sterol composition in Saccharomyces cerevisiae: relationship between structure and activity. Sajbidor, J., Lamacka, M., Baláz, S., Huong, L.M., Ciesarova, Z. J. Pharm. Pharmacol. (1998) [Pubmed]
  4. Acute myocardial infarction with papillary muscle rupture. Hackel, D.B., Wagner, G.S. Clinical cardiology. (1993) [Pubmed]
  5. Open mitral commissurotomies. Analysis of 100 cases. Aytaç, A., Saylam, A., Yurdakul, Y., Ikizler, C., Olga, R. The Journal of cardiovascular surgery. (1978) [Pubmed]
  6. The fenpropimorph resistance gene FEN2 from Saccharomyces cerevisiae encodes a plasma membrane H+-pantothenate symporter. Stolz, J., Sauer, N. J. Biol. Chem. (1999) [Pubmed]
  7. A link between sterol biosynthesis, the cell wall, and cellulose in Arabidopsis. Schrick, K., Fujioka, S., Takatsuto, S., Stierhof, Y.D., Stransky, H., Yoshida, S., Jürgens, G. Plant J. (2004) [Pubmed]
  8. Sterols regulate development and gene expression in Arabidopsis. He, J.X., Fujioka, S., Li, T.C., Kang, S.G., Seto, H., Takatsuto, S., Yoshida, S., Jang, J.C. Plant Physiol. (2003) [Pubmed]
  9. Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors. Henry, K.W., Nickels, J.T., Edlind, T.D. Antimicrob. Agents Chemother. (2000) [Pubmed]
  10. Physiological effects of fenpropimorph on wild-type Saccharomyces cerevisiae and fenpropimorph-resistant mutants. Lorenz, R.T., Parks, L.W. Antimicrob. Agents Chemother. (1991) [Pubmed]
  11. Investigation of the role of sterol delta 8-->7-isomerase in the sensitivity of Saccharomyces cerevisiae to fenpropimorph. Kelly, D.E., Rose, M.E., Kelly, S.L. FEMS Microbiol. Lett. (1994) [Pubmed]
  12. Brucella classification and regional distribution. Morgan, W.J. Dev. Biol. Stand. (1984) [Pubmed]
  13. Inhibition by the fungicide fenpropimorph of cholesterol biosynthesis in 3T3 fibroblasts. Corio-Costet, M.F., Gerst, N., Benveniste, P., Schuber, F. Biochem. J. (1988) [Pubmed]
  14. Fenpropimorph affects uptake of uracil and cytosine in Saccharomyces cerevisiae. Crowley, J.H., Lorenz, R.T., Parks, L.W. Antimicrob. Agents Chemother. (1994) [Pubmed]
  15. Specific patterns of changes in wheat gene expression after treatment with three antifungal compounds. Pasquer, F., Isidore, E., Zarn, J., Keller, B. Plant Mol. Biol. (2005) [Pubmed]
  16. The action of the systemic fungicides tridemorph and fenpropimorph on sterol biosynthesis by the soil amoeba Acanthamoeba polyphaga. Raederstorff, D., Rohmer, M. Eur. J. Biochem. (1987) [Pubmed]
  17. Comparison of wind tunnel and field experiments to measure potential deposition of fenpropimorph following volatilisation from treated crops. Hassink, J., Platz, K., Stadler, R., Zangmeister, W., Fent, G., M??ndel, M., Kubiak, R. Pest Manag. Sci. (2007) [Pubmed]
  18. Human lamin B receptor exhibits sterol C14-reductase activity in Saccharomyces cerevisiae. Silve, S., Dupuy, P.H., Ferrara, P., Loison, G. Biochim. Biophys. Acta (1998) [Pubmed]
  19. Determination of fenpropimorph in citrus fruit by reversed-phase high-performance liquid chromatography. Tadeo, J.L., Lafuente, M.T. J. Chromatogr. (1987) [Pubmed]
  20. The influence of newly synthesised fenporpimorph derivatives on some pathogen yeasts. Breierová, E., Sajbidor, J., Lamacka, M. Z. Naturforsch., C, J. Biosci. (2001) [Pubmed]
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