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Chemical Compound Review

Perflexane     1,1,1,2,2,3,3,4,4,5,5,6,6,6...

Synonyms: Imagent?, Imavist?, FlutecR PP1, Flutec PP1, FC-72, ...
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Disease relevance of Perflexane


Psychiatry related information on Perflexane


High impact information on Perflexane


Biological context of Perflexane


Anatomical context of Perflexane

  • RESULTS: Using both video-enhanced contrast and electron microscopy, the authors observed that perfluorohexane droplets were phagocytosed by activated monocytes as well as by in vitro--cultured AMs within 1--3 h [7].
  • After establishment of lung injury (PaO(2)/F(IO(2)) ratio, <200; pulmonary artery occlusion pressure, <19 torr), seven animals were treated with 18% perfluorohexane vapor for 30 mins whereas seven animals served as controls [8].
  • Rough and haemocompatible films of poly(hydroxybutyrate) and smoother, but more thrombogenic, polysulphone films were treated by perfluorohexane and perfluorohexane + H2 plasmas to study the relative influence of surface roughness and surface energy on polymer thrombogenicity [9].
  • The deposition of thin fluorocarbon coatings from an argon plasma containing perfluorohexane gave very smooth and hydrophobic surfaces without affecting the filtering properties of the treated membranes [9].
  • MATERIALS AND METHODS: Atherosclerotic lesions were created in 14 rabbit aortas and imaged with color Doppler and B-mode US before and after the intravenous administration of 0.3 mL of AF0150, a US contrast agent [10].

Associations of Perflexane with other chemical compounds


Gene context of Perflexane

  • CONCLUSION: Taken together, our results demonstrate an interference of perfluorohexane with the expression of the procoagulant protein TF on monocytes and AMs as well as with the release of proinflammatory cytokines by MBCs [7].
  • In this paper, information from the self-diffusion coefficients of oil (PFH), surfactant counterion (TEA+), surfactant ion (FOS-), and water (HDO) during the transition is presented [14].

Analytical, diagnostic and therapeutic context of Perflexane


  1. Comparative effects of vaporized perfluorohexane and partial liquid ventilation in oleic acid-induced lung injury. de Abreu, M.G., Quelhas, A.D., Spieth, P., Bräuer, G., Knels, L., Kasper, M., Pino, A.V., Bleyl, J.U., Hübler, M., Bozza, F., Salluh, J., Kuhlisch, E., Giannella-Neto, A., Koch, T. Anesthesiology (2006) [Pubmed]
  2. Assessment of coronary stenoses of graded severity by myocardial contrast echocardiography. Galiuto, L., May-Newman, K., Del Balzo, U., Flaim, S.F., Iliceto, S., Demaria, A.N. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. (2002) [Pubmed]
  3. Imagent improves endocardial border delineation, inter-reader agreement, and the accuracy of segmental wall motion assessment. Nanda, N.C., Kitzman, D.W., Dittrich, H.C., Hall, G. Echocardiography (Mount Kisco, N.Y.) (2003) [Pubmed]
  4. Vaporized perfluorohexane attenuates ventilator-induced lung injury in isolated, perfused rabbit lungs. Gama de Abreu, M., Wilmink, B., Hübler, M., Koch, T. Anesthesiology (2005) [Pubmed]
  5. Carbomethoxychlorocarbene: spectroscopy, theory, chemistry and kinetics. Likhotvorik, I., Zhu, Z., Tae, E.L., Tippmann, E., Hill, B.T., Platz, M.S. J. Am. Chem. Soc. (2001) [Pubmed]
  6. Perfluorocarbon attenuates response of concanavalin A-stimulated mononuclear blood cells without altering ligand-receptor interaction. Haufe, D., Luther, T., Kotzsch, M., Knels, L., Koch, T. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  7. Perfluorohexane attenuates proinflammatory and procoagulatory response of activated monocytes and alveolar macrophages. Koch, T., Ragaller, M., Haufe , D., Hofer, A., Grosser, M., Albrecht, D.M., Kotzsch, M., Luther, T. Anesthesiology (2001) [Pubmed]
  8. Changes in pulmonary function and oxygenation during application of perfluorocarbon vapor in healthy and oleic acid-injured animals. Bleyl, J.U., Ragaller, M., Tschö, U., Regner, M., Hübler, M., Kanzow, M., Vincent, O., Albrecht, M. Crit. Care Med. (2002) [Pubmed]
  9. Modification of the biocompatible and haemocompatible properties of polymer substrates by plasma-deposited fluorocarbon coatings. Clarotti, G., Schue, F., Sledz, J., Ait Ben Aoumar, A., Geckeler, K.E., Orsetti, A., Paleirac, G. Biomaterials (1992) [Pubmed]
  10. Contrast-enhanced B-mode US angiography in the assessment of experimental in vivo and in vitro atherosclerotic disease. Sirlin, C.B., Lee, Y.Z., Girard, M.S., Peterson, T.M., Steinbach, G.C., Baker, K.G., Mattrey, R.F. Academic radiology. (2001) [Pubmed]
  11. Influence of plasma modification on biological properties of poly(ethylene terephthalate). Pigłowski, J., Gancarz, I., Staniszewska-Kuś, J., Paluch, D., Szymonowicz, M., Konieczny, A. Biomaterials (1994) [Pubmed]
  12. Fluorochemical mass flows in a municipal wastewater treatment facility. Schultz, M.M., Higgins, C.P., Huset, C.A., Luthy, R.G., Barofsky, D.F., Field, J.A. Environ. Sci. Technol. (2006) [Pubmed]
  13. Oxidase and oxygenase function of the microsomal cytochrome P450 monooxygenase system. Kuthan, H., Ullrich, V. Eur. J. Biochem. (1982) [Pubmed]
  14. Aqueous microemulsions of a fluorinated surfactant and oil studied by PFG-NMR: transformation from threadlike to spherical micelles. Johannessen, E., Walderhaug, H., Balinov, B. Langmuir : the ACS journal of surfaces and colloids. (2004) [Pubmed]
  15. Evaluation of dynamic changes in microvascular flow during ischemia-reperfusion by myocardial contrast echocardiography. Galiuto, L., DeMaria, A.N., May-Newman, K., Del Balzo, U., Ohmori, K., Bhargava, V., Flaim, S.F., Iliceto, S. J. Am. Coll. Cardiol. (1998) [Pubmed]
  16. Mechanism of parenchymal enhancement of the liver with a microbubble-based US contrast medium: an intravital microscopy study in rats. Kono, Y., Steinbach, G.C., Peterson, T., Schmid-Schönbein, G.W., Mattrey, R.F. Radiology. (2002) [Pubmed]
  17. Renal cortical perfusion in rabbits: visualization with color amplitude imaging and an experimental microbubble-based US contrast agent. Taylor, G.A., Ecklund, K., Dunning, P.S. Radiology. (1996) [Pubmed]
  18. Vaporized perfluorocarbon improves oxygenation and pulmonary function in an ovine model of acute respiratory distress syndrome. Bleyl, J.U., Ragaller, M., Tschö, U., Regner, M., Kanzow, M., Hübler, M., Rasche, S., Albrecht, M. Anesthesiology (1999) [Pubmed]
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