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Gene Review

WASF2  -  WAS protein family, member 2

Homo sapiens

Synonyms: IMD2, Protein WAVE-2, SCAR2, Verprolin homology domain-containing protein 2, WASF4, ...
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Disease relevance of WASF2


Psychiatry related information on WASF2

  • Mothers' Wave 2 psychological functioning was associated with involved-supportive parenting of the YS at Wave 3 [3].
  • MAIN OUTCOME MEASURE: Mammogram and clinical breast examination during the past year and performance of monthly breast self examination, with the screening rates in wave 2 directly standardized to the income and education distribution of wave 1 in each area [4].
  • In the present study, the temporal stability of wave 1 obsessive-compulsive disorder diagnoses at wave 2 was examined, as well as relationships with comorbid diagnoses [5].
  • METHODS: After an initial (wave 1) multistage assessment (1995 through 1997) to identify prevalent cases of dementia, we used similar methods 3 years later (wave 2) to identify 104 incident cases of AD among the 3308 survivors [6].
  • At wave 2, mothers completed a survey of mental health services their child had received [7].

High impact information on WASF2

  • Abi1 interacts directly with the WHD domain of WAVE2, increases WAVE2 actin polymerization activity and mediates the assembly of a WAVE2-Abi1-Nap1-PIR121 complex [8].
  • WAVE2 belongs to a family of proteins that mediates actin reorganization by relaying signals from Rac to the Arp2/3 complex, resulting in lamellipodia protrusion [8].
  • Purified WAVE2 and purified WAVE2 complex were activated by IRSp53 in a Rac-dependent manner with PIP(3)-containing liposomes [9].
  • IRSp53 binds to both Rac and Cdc42 and is proposed to link Rac to WAVE2 [9].
  • We found that the knockdown of IRSp53 by RNA interference decreased lamellipodium formation without a decrease in the amount of WAVE2 complex [9].

Biological context of WASF2


Anatomical context of WASF2


Associations of WASF2 with chemical compounds


Physical interactions of WASF2


Regulatory relationships of WASF2


Other interactions of WASF2

  • Thus, Abi1 orchestrates the proper assembly of the WAVE2 complex and mediates its activation at the leading edge in vivo [8].
  • Although portions of these 3 isoforms were commonly distributed in the actin- and actin-related protein 2 and 3 (Arp2/3)-rich edge of the lamellipodia in spreading platelets, only WAVE2 remained in the cell fringe following detergent extraction or fixation of the cells [22].
  • Predictors at wave 1 for wave 2 cases status included lower socioeconomic status, less family cohesiveness, and greater family inhibition/control [23].
  • Wave 2 and especially wave 3 enhanced programs provided significantly more social and medical services than control programs [24].
  • WAVE2 is a member of the Wiskott-Aldrich syndrome protein family of cytoskeletal regulatory proteins shown to link Rac activation to actin remodeling via induction of Arp 2/3 activity [10].

Analytical, diagnostic and therapeutic context of WASF2

  • We reconstitute the Wave-2 complex by cotranslating in vitro the five subunits and use this system together with specific immunoprecipitations to study the molecular architecture of the complex [14].
  • RESULTS: Mammography use between waves increased significantly (P < 0.05 after adjusting for education, income, and age) in all but one area (from 19% to 33% in wave 1 to 35% to 59% in wave 2) [4].
  • RESULTS: Among 112 cases of HCCs, the immunohistochemistry data indicated significant increase of WAVE2 expression levels in 71 cases [25].
  • Among the 112 cases, 31 paired HCC and paracarcinomatous liver tissue specimens were analyzed for WAVE2 levels by reverse transcription-PCR and Western blotting, respectively [25].
  • Kaplan-Meier disease-free survival and overall survival curves were analyzed to determine the prognostic significance of the coexpression of Arp2 and WAVE2 [2].


  1. WAVE2 signaling mediates invasion of polarized epithelial cells by Salmonella typhimurium. Shi, J., Scita, G., Casanova, J.E. J. Biol. Chem. (2005) [Pubmed]
  2. Coexpression of actin-related protein 2 and Wiskott-Aldrich syndrome family verproline-homologous protein 2 in adenocarcinoma of the lung. Semba, S., Iwaya, K., Matsubayashi, J., Serizawa, H., Kataba, H., Hirano, T., Kato, H., Matsuoka, T., Mukai, K. Clin. Cancer Res. (2006) [Pubmed]
  3. Longitudinal direct and indirect pathways linking older sibling competence to the development of younger sibling competence. Brody, G.H., Kim, S., Murry, V.M., Brown, A.C. Developmental psychology. (2003) [Pubmed]
  4. Breast cancer screening among women from 65 to 74 years of age in 1987-88 and 1991. NCI Breast Cancer Screening Consortium. Coleman, E.A., Feuer, E.J. Ann. Intern. Med. (1992) [Pubmed]
  5. Stability of diagnosis of obsessive-compulsive disorder in the Epidemiologic Catchment Area study. Nelson, E., Rice, J. The American journal of psychiatry. (1997) [Pubmed]
  6. Antihypertensive medication use and incident Alzheimer disease: the Cache County Study. Khachaturian, A.S., Zandi, P.P., Lyketsos, C.G., Hayden, K.M., Skoog, I., Norton, M.C., Tschanz, J.T., Mayer, L.S., Welsh-Bohmer, K.A., Breitner, J.C. Arch. Neurol. (2006) [Pubmed]
  7. Mental health service use among young children receiving pediatric primary care. Lavigne, J.V., Arend, R., Rosenbaum, D., Binns, H.J., Christoffel, K.K., Burns, A., Smith, A. Journal of the American Academy of Child and Adolescent Psychiatry. (1998) [Pubmed]
  8. Abi1 is essential for the formation and activation of a WAVE2 signalling complex. Innocenti, M., Zucconi, A., Disanza, A., Frittoli, E., Areces, L.B., Steffen, A., Stradal, T.E., Di Fiore, P.P., Carlier, M.F., Scita, G. Nat. Cell Biol. (2004) [Pubmed]
  9. Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac. Suetsugu, S., Kurisu, S., Oikawa, T., Yamazaki, D., Oda, A., Takenawa, T. J. Cell Biol. (2006) [Pubmed]
  10. Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation. Leng, Y., Zhang, J., Badour, K., Arpaia, E., Freeman, S., Cheung, P., Siu, M., Siminovitch, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  11. Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. Suetsugu, S., Miki, H., Takenawa, T. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  12. Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage. Kashiwagi, H., Shiraga, M., Kato, H., Honda, S., Sako, M., Kurata, Y., Kanakura, Y., Tomiyama, Y. J. Thromb. Haemost. (2005) [Pubmed]
  13. MRP-1/CD9 gene transduction regulates the actin cytoskeleton through the downregulation of WAVE2. Huang, C.L., Ueno, M., Liu, D., Masuya, D., Nakano, J., Yokomise, H., Nakagawa, T., Miyake, M. Oncogene (2006) [Pubmed]
  14. Purification and architecture of the ubiquitous Wave complex. Gautreau, A., Ho, H.Y., Li, J., Steen, H., Gygi, S.P., Kirschner, M.W. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  15. The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation. Nolz, J.C., Gomez, T.S., Zhu, P., Li, S., Medeiros, R.B., Shimizu, Y., Burkhardt, J.K., Freedman, B.D., Billadeau, D.D. Curr. Biol. (2006) [Pubmed]
  16. WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor. Bierne, H., Miki, H., Innocenti, M., Scita, G., Gertler, F.B., Takenawa, T., Cossart, P. J. Cell. Sci. (2005) [Pubmed]
  17. Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion. Yamazaki, D., Oikawa, T., Takenawa, T. J. Cell. Sci. (2007) [Pubmed]
  18. Trends of HIV infection among injection drug users in Brazil in the 1990s: the impact of changes in patterns of drug use. Mesquita, F., Kral, A., Reingold, A., Bueno, R., Trigueiros, D., Araujo, P.J. J. Acquir. Immune Defic. Syndr. (2001) [Pubmed]
  19. Changes in the practice of percutaneous coronary intervention: a comparison of enrollment waves in the National Heart, Lung, and Blood Institute (NHLBI) Dynamic Registry. Laskey, W.K., Williams, D.O., Vlachos, H.A., Cohen, H., Holmes, D.R., King, S.B., Kelsey, S.F., Slater, J., Faxon, D., Al-Bassam, M., Block, E., Detre, K.M. Am. J. Cardiol. (2001) [Pubmed]
  20. c-Abl Interacts with the WAVE2 Signaling Complex to Induce Membrane Ruffling and Cell Spreading. Stuart, J.R., Gonzalez, F.H., Kawai, H., Yuan, Z.M. J. Biol. Chem. (2006) [Pubmed]
  21. Changes in genetic and environmental influences on depressive symptoms across adolescence and young adulthood. Lau, J.Y., Eley, T.C. The British journal of psychiatry : the journal of mental science. (2006) [Pubmed]
  22. WAVE/Scars in platelets. Oda, A., Miki, H., Wada, I., Yamaguchi, H., Yamazaki, D., Suetsugu, S., Nakajima, M., Nakayama, A., Okawa, K., Miyazaki, H., Matsuno, K., Ochs, H.D., Machesky, L.M., Fujita, H., Takenawa, T. Blood (2005) [Pubmed]
  23. Psychiatric disorders with onset in the preschool years: II. Correlates and predictors of stable case status. Lavigne, J.V., Arend, R., Rosenbaum, D., Binns, H.J., Christoffel, K.K., Gibbons, R.D. Journal of the American Academy of Child and Adolescent Psychiatry. (1998) [Pubmed]
  24. Supplemental social services improve outcomes in public addiction treatment. McLellan, A.T., Hagan, T.A., Levine, M., Gould, F., Meyers, K., Bencivengo, M., Durell, J. Addiction (1998) [Pubmed]
  25. Increased expression of wiskott-Aldrich syndrome protein family verprolin-homologous protein 2 correlated with poor prognosis of hepatocellular carcinoma. Yang, L.Y., Tao, Y.M., Ou, D.P., Wang, W., Chang, Z.G., Wu, F. Clin. Cancer Res. (2006) [Pubmed]
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