The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Calcr  -  calcitonin receptor

Mus musculus

Synonyms: CT-R, Calcitonin receptor, Clr
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Calcr


High impact information on Calcr


Chemical compound and disease context of Calcr


Biological context of Calcr


Anatomical context of Calcr


Associations of Calcr with chemical compounds

  • In 1,25-(OH)2D3 treated cultures CTR mRNA was detectable in nonadherent cells on day 3 and in adherent cells on day 5 and thereafter [12].
  • The CTR mRNA transcript contains several adenylate/uridylate (AU)-rich destabilizing elements in the 3' untranslated region (3'UTR) [17].
  • Consistent with these results, treatment of OCLs with sCT greatly decreased the expression of CTR messenger RNA, whereas no significant effect was observed on the tartrate-resistant acid phosphatase messenger RNA expression, a marker of resorptive capacity of osteoclasts [18].
  • Moreover, competitive RT-PCR analysis revealed that 1-h treatment with CT reduced the level of CTR heterogeneous nuclear RNA to 10% in a cycloheximide-independent manner [13].
  • From a Scatchard plot analysis, DEX enhanced CTR number (212 +/- 64%) with a minimal change in the affinity to sCT [19].

Regulatory relationships of Calcr

  • These results suggest that CT down-regulates C1a-CTR mRNA expression at least in part by a transcriptional mechanism, thereby contributing to the ligand-induced desensitization in cells of the osteoclast lineage [13].
  • The proportion of CTR-positive cells expressing NSE and Mac-1 to total CTR-positive mononuclear cells decreased time dependently [20].
  • The analog (CTR) and salmon calcitonin (sCT) stimulated kidney cell adenylate cyclase activity and inhibited bone resorption in organ cultures of fetal rat long bones with similar potencies and efficacies [2].

Other interactions of Calcr

  • Greater than additive potentiations of CTR mRNA and RANKL mRNA and protein were observed when D3 and dexamethasone were combined [21].
  • GM-CSF inhibited the development of mature function (bone resorption) to a greater extent than it inhibited CT-receptor-positive cell formation [22].
  • Conversely, IL3, which also has no effect on mature osteoclasts, by itself induced CT-receptor expression but not bone resorption; in combination with 1,25(OH)2D3 it induced a threefold increase in bone resorption and CT-receptor-positive cells compared with cultures incubated with 1,25(OH)2D3 alone [22].
  • Osteoclast-like cells expressed CT receptor (CTR), CT receptor-like receptor (CRLR) and RAMP2, but did not express RAMP1 or RAMP3 [23].
  • These results indicated (1) that a pure population of osteoclast-like cells can be prepared by LCM and gene expression of this population can be analyzed by RT-PCR and (2) that RT-PCR shows that osteoclast-like cells express RAMP2, CTR and CRLR, suggesting the potential for adrenomedullin binding to osteoclast-like cells [23].

Analytical, diagnostic and therapeutic context of Calcr


  1. Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. Dacquin, R., Davey, R.A., Laplace, C., Levasseur, R., Morris, H.A., Goldring, S.R., Gebre-Medhin, S., Galson, D.L., Zajac, J.D., Karsenty, G. J. Cell Biol. (2004) [Pubmed]
  2. A noncyclical analog of salmon calcitonin (N alpha-propionyl Di-Ala1,7,des-Leu19 sCT) retains full potency without inducing anorexia in rats. Yates, A.J., Gutierrez, G.E., Garrett, I.R., Mencel, J.J., Nuss, G.W., Schreiber, A.B., Mundy, G.R. Endocrinology (1990) [Pubmed]
  3. F.9 embryonal carcinoma cell calcitonin autocrine system: correlation between immunoreactive calcitonin secretion and calcitonin receptor number. Binet, E., Laurent, P., Evain-Brion, D. J. Cell. Physiol. (1985) [Pubmed]
  4. Calcitonin stimulates multiple stages of angiogenesis by directly acting on endothelial cells. Chigurupati, S., Kulkarni, T., Thomas, S., Shah, G. Cancer Res. (2005) [Pubmed]
  5. Expression of calcitonin receptors in mouse preimplantation embryos and their function in the regulation of blastocyst differentiation by calcitonin. Wang, J., Rout, U.K., Bagchi, I.C., Armant, D.R. Development (1998) [Pubmed]
  6. Prostaglandin E2 receptors EP2 and EP4 are down-regulated during differentiation of mouse osteoclasts from their precursors. Kobayashi, Y., Take, I., Yamashita, T., Mizoguchi, T., Ninomiya, T., Hattori, T., Kurihara, S., Ozawa, H., Udagawa, N., Takahashi, N. J. Biol. Chem. (2005) [Pubmed]
  7. Differential activities of plant polyphenols on the binding and internalization of cholera toxin in vero cells. Morinaga, N., Iwamaru, Y., Yahiro, K., Tagashira, M., Moss, J., Noda, M. J. Biol. Chem. (2005) [Pubmed]
  8. Calcitonin receptors as markers for osteoclastic differentiation: correlation between generation of bone-resorptive cells and cells that express calcitonin receptors in mouse bone marrow cultures. Hattersley, G., Chambers, T.J. Endocrinology (1989) [Pubmed]
  9. Effects of peptides from the calcitonin genes on bone and bone cells. Zaidi, M., Chambers, T.J., Bevis, P.J., Beacham, J.L., Gaines Das, R.E., MacIntyre, I. Quarterly journal of experimental physiology (Cambridge, England) (1988) [Pubmed]
  10. Effect of prostaglandins E1, E2, and F2 alpha on osteoclast formation in mouse bone marrow cultures. Collins, D.A., Chambers, T.J. J. Bone Miner. Res. (1991) [Pubmed]
  11. Effects of continuous calcitonin treatment on osteoclast-like cell development and calcitonin receptor expression in mouse bone marrow cultures. Ikegame, M., Rakopoulos, M., Martin, T.J., Moseley, J.M., Findlay, D.M. J. Bone Miner. Res. (1996) [Pubmed]
  12. Expression of the calcitonin receptor in bone marrow cell cultures and in bone: a specific marker of the differentiated osteoclast that is regulated by calcitonin. Lee, S.K., Goldring, S.R., Lorenzo, J.A. Endocrinology (1995) [Pubmed]
  13. Calcitonin-dependent down-regulation of the mouse C1a calcitonin receptor in cells of the osteoclast lineage involves a transcriptional mechanism. Inoue, D., Shih, C., Galson, D.L., Goldring, S.R., Horne, W.C., Baron, R. Endocrinology (1999) [Pubmed]
  14. Tissue-specific and ubiquitous promoters direct the expression of alternatively spliced transcripts from the calcitonin receptor gene. Anusaksathien, O., Laplace, C., Li, X., Ren, Y., Peng, L., Goldring, S.R., Galson, D.L. J. Biol. Chem. (2001) [Pubmed]
  15. Cholera toxin-stimulated bone resorption in cultured mouse calvarial bones not inhibited by calcitonin: a possible interaction at the stimulatory G protein. Ransjö, M., Lerner, U.H., Ljunggren, O. J. Bone Miner. Res. (1994) [Pubmed]
  16. Characterization of amylin and calcitonin receptor binding in the mouse alpha-thyroid-stimulating hormone thyrotroph cell line. Perry, K.J., Quiza, M., Myers, D.E., Morfis, M., Christopoulos, G., Sexton, P.M. Endocrinology (1997) [Pubmed]
  17. Interaction between 3' untranslated region of calcitonin receptor messenger ribonucleic acid (RNA) and adenylate/uridylate (AU)-rich element binding proteins (AU-rich RNA-binding factor 1 and Hu antigen R). Yasuda, S., Wada, S., Arao, Y., Kogawa, M., Kayama, F., Katayama, S. Endocrinology (2004) [Pubmed]
  18. Calcitonin receptor down-regulation relates to calcitonin resistance in mature mouse osteoclasts. Wada, S., Udagawa, N., Nagata, N., Martin, T.J., Findlay, D.M. Endocrinology (1996) [Pubmed]
  19. Glucocorticoid regulation of calcitonin receptor in mouse osteoclast-like multinucleated cells. Wada, S., Akatsu, T., Tamura, T., Takahashi, N., Suda, T., Nagata, N. J. Bone Miner. Res. (1994) [Pubmed]
  20. Postmitotic osteoclast precursors are mononuclear cells which express macrophage-associated phenotypes. Takahashi, N., Udagawa, N., Tanaka, S., Murakami, H., Owan, I., Tamura, T., Suda, T. Dev. Biol. (1994) [Pubmed]
  21. Glucocorticoid regulation of osteoclast differentiation and expression of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand, osteoprotegerin, and receptor activator of NF-kappaB in mouse calvarial bones. Swanson, C., Lorentzon, M., Conaway, H.H., Lerner, U.H. Endocrinology (2006) [Pubmed]
  22. Effects of interleukin 3 and of granulocyte-macrophage and macrophage colony stimulating factors on osteoclast differentiation from mouse hemopoietic tissue. Hattersley, G., Chambers, T.J. J. Cell. Physiol. (1990) [Pubmed]
  23. Osteoclast-like cells express receptor activity modifying protein 2: application of laser capture microdissection. Nakamura, M., Morimoto, S., Yang, Q., Hisamatsu, T., Hanai, N., Nakamura, Y., Mori, I., Kakudo, K. J. Mol. Endocrinol. (2005) [Pubmed]
  24. Calcitonin receptor isoforms in mouse and rat osteoclasts. Ikegame, M., Rakopoulos, M., Zhou, H., Houssami, S., Martin, T.J., Moseley, J.M., Findlay, D.M. J. Bone Miner. Res. (1995) [Pubmed]
WikiGenes - Universities