Gene Review:
Casp2 - caspase 2
Mus musculus
Synonyms:
CASP-2, Caspase-2, ICH-1, Ich-1, Ich1, ...
- Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol. Mohan, J., Gandhi, A.A., Bhavya, B.C., Rashmi, R., Karunagaran, D., Indu, R., Santhoshkumar, T.R. J. Biol. Chem. (2006)
- Gustatory innervation and bax-dependent caspase-2: participants in the life and death pathways of mouse taste receptor cells. Zeng, Q., Kwan, A., Oakley, B. J. Comp. Neurol. (2000)
- Caspase-2 mediates neuronal cell death induced by beta-amyloid. Troy, C.M., Rabacchi, S.A., Friedman, W.J., Frappier, T.F., Brown, K., Shelanski, M.L. J. Neurosci. (2000)
- Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Kumar, S., Kinoshita, M., Noda, M., Copeland, N.G., Jenkins, N.A. Genes Dev. (1994)
- Salmonella-induced caspase-2 activation in macrophages: a novel mechanism in pathogen-mediated apoptosis. Jesenberger, V., Procyk, K.J., Yuan, J., Reipert, S., Baccarini, M. J. Exp. Med. (2000)
- Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Nutt, L.K., Margolis, S.S., Jensen, M., Herman, C.E., Dunphy, W.G., Rathmell, J.C., Kornbluth, S. Cell (2005)
- Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Li, P., Allen, H., Banerjee, S., Franklin, S., Herzog, L., Johnston, C., McDowell, J., Paskind, M., Rodman, L., Salfeld, J. Cell (1995)
- Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Wang, L., Miura, M., Bergeron, L., Zhu, H., Yuan, J. Cell (1994)
- Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Enari, M., Talanian, R.V., Wong, W.W., Nagata, S. Nature (1996)
- Dissecting processing and apoptotic activity of a cysteine protease by mutant analysis. Allet, B., Hochmann, A., Martinou, I., Berger, A., Missotten, M., Antonsson, B., Sadoul, R., Martinou, J.C., Bernasconi, L. J. Cell Biol. (1996)
- In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis. Tu, S., McStay, G.P., Boucher, L.M., Mak, T., Beere, H.M., Green, D.R. Nat. Cell Biol. (2006)
- Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Berube, C., Boucher, L.M., Ma, W., Wakeham, A., Salmena, L., Hakem, R., Yeh, W.C., Mak, T.W., Benchimol, S. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Role of prodomain in importin-mediated nuclear localization and activation of caspase-2. Baliga, B.C., Colussi, P.A., Read, S.H., Dias, M.M., Jans, D.A., Kumar, S. J. Biol. Chem. (2003)
- Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens. Werner, A.B., Tait, S.W., de Vries, E., Eldering, E., Borst, J. J. Biol. Chem. (2004)
- p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury. Seth, R., Yang, C., Kaushal, V., Shah, S.V., Kaushal, G.P. J. Biol. Chem. (2005)
- Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis. Guicciardi, M.E., Bronk, S.F., Werneburg, N.W., Yin, X.M., Gores, G.J. Gastroenterology (2005)
- Mitochondrial release of caspase-2 and -9 during the apoptotic process. Susin, S.A., Lorenzo, H.K., Zamzami, N., Marzo, I., Brenner, C., Larochette, N., Prévost, M.C., Alzari, P.M., Kroemer, G. J. Exp. Med. (1999)
- Sequential caspase-2 and caspase-8 activation upstream of mitochondria during ceramideand etoposide-induced apoptosis. Lin, C.F., Chen, C.L., Chang, W.T., Jan, M.S., Hsu, L.J., Wu, R.H., Tang, M.J., Chang, W.C., Lin, Y.S. J. Biol. Chem. (2004)
- Processing of the Nedd2 precursor by ICE-like proteases and granzyme B. Harvey, N.L., Trapani, J.A., Fernandes-Alnemri, T., Litwack, G., Alnemri, E.S., Kumar, S. Genes Cells (1996)
- Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases. Deshmukh, M., Vasilakos, J., Deckwerth, T.L., Lampe, P.A., Shivers, B.D., Johnson, E.M. J. Cell Biol. (1996)
- Caspase-2-induced Apoptosis Requires Bid Cleavage: A Physiological Role for Bid in Heat Shock-induced Death. Bonzon, C., Bouchier-Hayes, L., Pagliari, L.J., Green, D.R., Newmeyer, D.D. Mol. Biol. Cell (2006)
- Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis. Panaretakis, T., Laane, E., Pokrovskaja, K., Björklund, A.C., Moustakas, A., Zhivotovsky, B., Heyman, M., Shoshan, M.C., Grandér, D. Mol. Biol. Cell (2005)
- The proteolytic procaspase activation network: an in vitro analysis. Van de Craen, M., Declercq, W., Van den brande, I., Fiers, W., Vandenabeele, P. Cell Death Differ. (1999)
- Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9. O'Reilly, L.A., Ekert, P., Harvey, N., Marsden, V., Cullen, L., Vaux, D.L., Hacker, G., Magnusson, C., Pakusch, M., Cecconi, F., Kuida, K., Strasser, A., Huang, D.C., Kumar, S. Cell Death Differ. (2002)
- Elevated levels of cysteine protease activity in saliva and salivary glands of the nonobese diabetic (NOD) mouse model for Sjögren syndrome. Robinson, C.P., Yamachika, S., Alford, C.E., Cooper, C., Pichardo, E.L., Shah, N., Peck, A.B., Humphreys-Beher, M.G. Proc. Natl. Acad. Sci. U.S.A. (1997)