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Gene Review

CD200R1  -  CD200 receptor 1

Homo sapiens

Synonyms: CD200 cell surface glycoprotein receptor, CD200R, CRTR2, Cell surface glycoprotein CD200 receptor 1, Cell surface glycoprotein OX2 receptor 1, ...
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Disease relevance of CD200R1


Psychiatry related information on CD200R1


High impact information on CD200R1

  • CD200 is a membrane glycoprotein that imparts an immunoregulatory signal through CD200R, leading to the suppression of T-cell-mediated immune responses [8].
  • We found that human CD200R is predominantly expressed on basophils in amounts higher than on other human peripheral blood leukocytes [9].
  • Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal [10]?
  • METHODS: We performed association studies on the insertion/deletion (I/D) sequence polymorphism of ACE and single nucleotide polymorphisms within the prepro-orexin (HCRT), orexin receptor 1 (HCRTR1), and orexin receptor 2 (HCRTR2) genes [11].
  • OXA-immunoreactive cells in the islets of Langerhans contained insulin with a subset expressing OX2R [12].

Biological context of CD200R1

  • Using the canine model, we investigated ( 1 ) whether hypocretin deficiency is involved in sporadic cases and ( 2 ) whether alterations in hypocretin neurons or ligand levels also contribute to the phenotype in Hcrtr 2 mutants [13].
  • No relationship was found between narcolepsy and DLA in Hcrtr2-mediated narcolepsy but loose genetic linkage was observed (Zmax=2.3 at theta=25%, m= 40) [14].
  • Recent studies have linked the development of autosomal recessive canine narcolepsy to a disruption of the hypocretin receptor 2 (Hcrtr2) gene on the same chromosome as the canine MHC region (CFA12), but not close to the DLA [14].
  • The expression of both HCRTR2 and MEF2C in the peripheral blood was validated by reverse transcription PCR [15].
  • Gene expression for OX1R and OX2R in central and peripheral tissues was analysed using quantitative real time RT-PCR [16].

Anatomical context of CD200R1

  • In order to establish protein array technology for the characterization of the weak interactions between leukocyte membrane proteins, we selected the human leukocyte membrane protein CD200 (OX2) and its cell surface receptor (hCD200R) as a model system [17].
  • Because monocytic myeloid cells provide a link between the innate and adaptive immune response, mechanisms to control their function through receptors such as CD200R will have therapeutic potential [10].
  • Spleen expresses cell surface CD200R1, while bone marrow shows predominantly expression of cell surface CD200R2/R3 [18].
  • High levels of OX1-R mRNA and low levels of OX2-R mRNA have been previously detected in the human adrenal cortex and medulla [2].
  • Protein expression of both OR receptors in human testis was confirmed by Western blotting analysis, with apparent molecular masses of 50 kDa for OX1R and 40 kDa for OX2R [19].

Associations of CD200R1 with chemical compounds

  • CD200 (OX2) is a broadly distributed cell surface glycoprotein that interacts with a receptor on myeloid cells (CD200R) involved in regulation of macrophage function [20].
  • We found a significant decrease in histamine content in the cortex and thalamus, two structures important for histamine-mediated cortical arousal, in Hcrtr-2 mutated narcoleptic Dobermans [21].
  • While the HCRTR2 1246G allele was significantly associated with CH in this group, treatment outcomes with triptans, oxygen, verapamil and corticosteroids remained unaffected [4].
  • By the double immunofluorescence techniques, we demonstrated that virtually all medullar cells (epinephrine and norepinephrine cells) expressed OX2R [22].

Physical interactions of CD200R1

  • We report the first characterization of human CD200R (hCD200R) and define its binding characteristics to hCD200 [23].

Regulatory relationships of CD200R1

  • CONCLUSIONS: We conclude that CD200 triggering of bone-marrow DCs in the absence of CD200R1 engagement induces CD4(+)CD25(+) Treg, and these cloned antigen-specific Treg may have clinical utility [18].

Other interactions of CD200R1

  • BACKGROUND: CD200 delivers an immunsuppressive signal that augments allograft survival following interaction with its receptor, CD200R1 [24].
  • CD200 receptor and fractalkine receptor stimulation was achieved by addition to explants of CD200:Fc fusion protein and recombinant cytokine respectively, with or without LPS-IFNgamma stimulation that is known to suppress migration [25].
  • Detection of autoantibodies against hypocretin, hcrtrl, and hcrtr2 in narcolepsy: anti-Hcrt system antibody in narcolepsy [6].
  • Orexins orchestrate their actions by binding and activating two types of G protein-coupled receptors, OR-1 receptor (OX1R) and OR-2 receptor (OX2R) [19].

Analytical, diagnostic and therapeutic context of CD200R1


  1. Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor. Foster-Cuevas, M., Wright, G.J., Puklavec, M.J., Brown, M.H., Barclay, A.N. J. Virol. (2004) [Pubmed]
  2. Human pheochromocytomas express orexin receptor type 2 gene and display an in vitro secretory response to orexins A and B. Mazzocchi, G., Malendowicz, L.K., Aragona, F., Rebuffat, P., Gottardo, L., Nussdorfer, G.G. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  3. Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. Zhu, Y., Miwa, Y., Yamanaka, A., Yada, T., Shibahara, M., Abe, Y., Sakurai, T., Goto, K. J. Pharmacol. Sci. (2003) [Pubmed]
  4. The G1246A polymorphism in the hypocretin receptor 2 gene is not associated with treatment response in cluster headache. Schürks, M., Kurth, T., Geissler, I., Tessmann, G., Diener, H.C., Rosskopf, D. Cephalalgia : an international journal of headache (2007) [Pubmed]
  5. Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells. Spinazzi, R., Rucinski, M., Neri, G., Malendowicz, L.K., Nussdorfer, G.G. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  6. Detection of autoantibodies against hypocretin, hcrtrl, and hcrtr2 in narcolepsy: anti-Hcrt system antibody in narcolepsy. Tanaka, S., Honda, Y., Inoue, Y., Honda, M. Sleep. (2006) [Pubmed]
  7. Effects of IV and ICV hypocretin-1 (orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin-ligand-deficient narcoleptic dog. Fujiki, N., Yoshida, Y., Ripley, B., Mignot, E., Nishino, S. Sleep. (2003) [Pubmed]
  8. CD200 is a new prognostic factor in multiple myeloma. Moreaux, J., Hose, D., Reme, T., Jourdan, E., Hundemer, M., Legouffe, E., Moine, P., Bourin, P., Moos, M., Corre, J., M??hler, T., De Vos, J., Rossi, J.F., Goldschmidt, H., Klein, B. Blood (2006) [Pubmed]
  9. Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. Shiratori, I., Yamaguchi, M., Suzukawa, M., Yamamoto, K., Lanier, L.L., Saito, T., Arase, H. J. Immunol. (2005) [Pubmed]
  10. Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? Minas, K., Liversidge, J. Crit. Rev. Immunol. (2006) [Pubmed]
  11. Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. Meerabux, J., Iwayama, Y., Sakurai, T., Ohba, H., Toyota, T., Yamada, K., Nagata, R., Irukayama-Tomobe, Y., Shimizu, H., Yoshitsugu, K., Ohta, K., Yoshikawa, T. Biol. Psychiatry (2005) [Pubmed]
  12. Inhibitory effect of exogenous orexin a on gastric emptying, plasma leptin, and the distribution of orexin and orexin receptors in the gut and pancreas in man. Ehrström, M., Gustafsson, T., Finn, A., Kirchgessner, A., Grybäck, P., Jacobsson, H., Hellström, P.M., Näslund, E. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  13. Hypocretin levels in sporadic and familial cases of canine narcolepsy. Ripley, B., Fujiki, N., Okura, M., Mignot, E., Nishino, S. Neurobiol. Dis. (2001) [Pubmed]
  14. DLA-DQB1 alleles and bone marrow transplantation experiments in narcoleptic dogs. Wagner, J.L., Storb, R., Storer, B., Mignot, E. Tissue Antigens (2000) [Pubmed]
  15. Correlation of psycho-neuroendocrine-immune (PNI) gene expression with symptoms of acute infectious mononucleosis. Vernon, S.D., Nicholson, A., Rajeevan, M., Dimulescu, I., Cameron, B., Whistler, T., Lloyd, A. Brain Res. (2006) [Pubmed]
  16. Expression of orexin receptors in the brain and peripheral tissues of the male sheep. Zhang, S., Blache, D., Vercoe, P.E., Adam, C.L., Blackberry, M.A., Findlay, P.A., Eidne, K.A., Martin, G.B. Regul. Pept. (2005) [Pubmed]
  17. Analysis of leukocyte membrane protein interactions using protein microarrays. Letarte, M., Voulgaraki, D., Hatherley, D., Foster-Cuevas, M., Saunders, N.J., Barclay, A.N. BMC Biochem. (2005) [Pubmed]
  18. Thymocyte/splenocyte-derived CD4+CD25+Treg stimulated by anti-CD200R2 derived dendritic cells suppress mixed leukocyte cultures and skin graft rejection. Gorczynski, R.M. Transplantation (2006) [Pubmed]
  19. Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system. Karteris, E., Chen, J., Randeva, H.S. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  20. The CD200 and CD200 receptor cell surface proteins interact through their N-terminal immunoglobulin-like domains. Hatherley, D., Barclay, A.N. Eur. J. Immunol. (2004) [Pubmed]
  21. Decreased brain histamine content in hypocretin/orexin receptor-2 mutated narcoleptic dogs. Nishino, S., Fujiki, N., Ripley, B., Sakurai, E., Kato, M., Watanabe, T., Mignot, E., Yanai, K. Neurosci. Lett. (2001) [Pubmed]
  22. Cellular localization of orexin receptors in human adrenal gland, adrenocortical adenomas and pheochromocytomas. Blanco, M., García-Caballero, T., Fraga, M., Gallego, R., Cuevas, J., Forteza, J., Beiras, A., Diéguez, C. Regul. Pept. (2002) [Pubmed]
  23. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. Wright, G.J., Cherwinski, H., Foster-Cuevas, M., Brooke, G., Puklavec, M.J., Bigler, M., Song, Y., Jenmalm, M., Gorman, D., McClanahan, T., Liu, M.R., Brown, M.H., Sedgwick, J.D., Phillips, J.H., Barclay, A.N. J. Immunol. (2003) [Pubmed]
  24. Decreased alloreactivity using donor cells from mice expressing a CD200 transgene under control of a tetracycline-inducible promoter. Yu, K., Chen, Z., Wang, S., Gorczynski, R. Transplantation (2005) [Pubmed]
  25. CD200 maintains microglial potential to migrate in adult human retinal explant model. Carter, D.A., Dick, A.D. Curr. Eye Res. (2004) [Pubmed]
  26. Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity. Thompson, M.D., Comings, D.E., Abu-Ghazalah, R., Jereseh, Y., Lin, L., Wade, J., Sakurai, T., Tokita, S., Yoshida, T., Tanaka, H., Yanagisawa, M., Burnham, W.M., Moldofsky, H. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004) [Pubmed]
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