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Cd200r1  -  CD200 receptor 1

Mus musculus

Synonyms: CD200 cell surface glycoprotein receptor, CD200R, Cell surface glycoprotein CD200 receptor 1, Cell surface glycoprotein OX2 receptor 1, Mox2r, ...
 
 
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Disease relevance of Cd200r1

  • In vivo experiments showed that an agonistic CD200R monoclonal antibody caused some amelioration in a model of experimental autoimmune encephalomyelitis but the COMP protein was cleared rapidly and had minimal effect [1].
  • Because manipulation of the CD200-CD200R interaction affects the outcome of rodent disease models, targeting of this pathway may have therapeutic utility [2].
  • Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor [3].
  • PROBLEM: We have shown that CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine immunoglobulin (Ig)G2a Fc region, regulates immune responses and prevents T helper (Th)1 cytokine-triggered spontaneous abortions in mice [4].
 

Psychiatry related information on Cd200r1

 

High impact information on Cd200r1

  • Regulation of myeloid cell function through the CD200 receptor [6].
  • This inhibition was dependent upon cross-linking the CD200R on monocytes, but not on cross-linking the CD200R on CD4+ T cells [6].
  • Thus, the CD200 receptor family consists of both activatory and inhibitory members like several other paired ligand receptors, such as signal regulatory protein, killer cell Ig-like receptor/KAR, LY49, dendritic cell immunoreceptor/dendritic cell immunoactivating receptor, and paired Ig-like type 2 receptor [7].
  • The CD200 receptor is a novel and potent regulator of murine and human mast cell function [8].
  • Unlike the majority of myeloid inhibitory receptors, CD200R does not contain a phosphatase recruiting inhibitory motif (ITIM); therefore, we conclude that CD200R represents a novel and potent inhibitory receptor that can be targeted in vivo to regulate mast cell-dependent pathologies [8].
 

Biological context of Cd200r1

 

Anatomical context of Cd200r1

  • CD200 (OX2) is a cell surface glycoprotein that interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function [7].
  • CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage [14].
  • In all, we provide direct evidence that the CD200-CD200R interaction controls monocyte/macrophage function in both murine and human systems, further supporting the potential clinical application of CD200R agonists for the treatment of chronic inflammatory diseases [6].
  • Transplant tolerance modifying antibody to CD200 receptor, but not CD200, alters cytokine production profile from stimulated macrophages [15].
  • Induction of tolerance-inducing antigen-presenting cells in bone marrow cultures in vitro using monoclonal antibodies to CD200R [16].
 

Associations of Cd200r1 with chemical compounds

  • Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement [17].
  • We found that upon ligand binding, CD200R is phosphorylated on tyrosine and subsequently binds to adapter proteins Dok1 and Dok2 [18].
  • METHODS: Retinal extract-immunised Lewis rats were treated day 3 and 5 post-immunisation with CD200R mAb or normal mouse serum [19].
  • The human CD200R gene spans a region of 52 kb, consists of nine exons, and encodes a 348-amino-acid cell-surface protein consisting of two IgFF domains in a typical V/C2 arrangement [20].
 

Physical interactions of Cd200r1

  • CD200 (OX2) is a membrane glycoprotein that interacts with a structurally related receptor (CD200R) involved in the regulation of macrophage function [1].
 

Regulatory relationships of Cd200r1

 

Other interactions of Cd200r1

 

Analytical, diagnostic and therapeutic context of Cd200r1

  • In addition, we report mRNA expression for other members of the CD 200 R-family (R2-R4) by quantitative real-time RT-PCR [21].
  • As a result, pDCs are capable of suppressing Ag-specific responses in vivo when transferred into recipient hosts after treatment with CD200-Ig [17].
  • In the present study, we examined the roles of these three tyrosines in CD200R-mediated inhibition by site-directed mutagenesis in mouse mast cells [10].
  • Northern blot and RT-PCR analyses indicated distinct patterns of CD200R isoform mRNA expression in different tissues and FACS analyses confirmed unique cell- and tissue-specific expression of the different CD200Rs. mAbs directed against the different isoforms modified the development of in vitro alloimmune responses [4].
  • Rabbit polyclonal and rat monoclonal antibodies (mAbs) to CD200R isoforms was used for fluorescence-activated cell sorter (FACS) analysis, to test for immunomodulatory effects on allogeneic mixed-lymphocyte responses in vitro, and for immunohistochemistry [4].

References

  1. Multivalent recombinant proteins for probing functions of leucocyte surface proteins such as the CD200 receptor. Voulgaraki, D., Mitnacht-Kraus, R., Letarte, M., Foster-Cuevas, M., Brown, M.H., Barclay, A.N. Immunology (2005) [Pubmed]
  2. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. Wright, G.J., Cherwinski, H., Foster-Cuevas, M., Brooke, G., Puklavec, M.J., Bigler, M., Song, Y., Jenmalm, M., Gorman, D., McClanahan, T., Liu, M.R., Brown, M.H., Sedgwick, J.D., Phillips, J.H., Barclay, A.N. J. Immunol. (2003) [Pubmed]
  3. Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor. Foster-Cuevas, M., Wright, G.J., Puklavec, M.J., Brown, M.H., Barclay, A.N. J. Virol. (2004) [Pubmed]
  4. Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface. Gorczynski, R.M., Chen, Z., Clark, D.A., Kai, Y., Lee, L., Nachman, J., Wong, S., Marsden, P. Am. J. Reprod. Immunol. (2004) [Pubmed]
  5. Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Willie, J.T., Chemelli, R.M., Sinton, C.M., Tokita, S., Williams, S.C., Kisanuki, Y.Y., Marcus, J.N., Lee, C., Elmquist, J.K., Kohlmeier, K.A., Leonard, C.S., Richardson, J.A., Hammer, R.E., Yanagisawa, M. Neuron (2003) [Pubmed]
  6. Regulation of myeloid cell function through the CD200 receptor. Jenmalm, M.C., Cherwinski, H., Bowman, E.P., Phillips, J.H., Sedgwick, J.D. J. Immunol. (2006) [Pubmed]
  7. Recombinant CD200 protein does not bind activating proteins closely related to CD200 receptor. Hatherley, D., Cherwinski, H.M., Moshref, M., Barclay, A.N. J. Immunol. (2005) [Pubmed]
  8. The CD200 receptor is a novel and potent regulator of murine and human mast cell function. Cherwinski, H.M., Murphy, C.A., Joyce, B.L., Bigler, M.E., Song, Y.S., Zurawski, S.M., Moshrefi, M.M., Gorman, D.M., Miller, K.L., Zhang, S., Sedgwick, J.D., Phillips, J.H. J. Immunol. (2005) [Pubmed]
  9. Control of myeloid activity during retinal inflammation. Dick, A.D., Carter, D., Robertson, M., Broderick, C., Hughes, E., Forrester, J.V., Liversidge, J. J. Leukoc. Biol. (2003) [Pubmed]
  10. Identification of tyrosine residues crucial for CD200R-mediated inhibition of mast cell activation. Zhang, S., Phillips, J.H. J. Leukoc. Biol. (2006) [Pubmed]
  11. A role for the immunomodulatory molecules CD200 and CD200R in regulating bone formation. Lee, L., Liu, J., Manuel, J., Gorczynski, R.M. Immunol. Lett. (2006) [Pubmed]
  12. Evidence of a role for CD200 in regulation of immune rejection of leukaemic tumour cells in C57BL/6 mice. Gorczynski, R.M., Chen, Z., Hu, J., Kai, Y., Lei, J. Clin. Exp. Immunol. (2001) [Pubmed]
  13. CD200, a "no danger" signal for hair follicles. Rosenblum, M.D., Yancey, K.B., Olasz, E.B., Truitt, R.L. J. Dermatol. Sci. (2006) [Pubmed]
  14. CD200 is a ligand for all members of the CD200R family of immunoregulatory molecules. Gorczynski, R., Chen, Z., Kai, Y., Lee, L., Wong, S., Marsden, P.A. J. Immunol. (2004) [Pubmed]
  15. Transplant tolerance modifying antibody to CD200 receptor, but not CD200, alters cytokine production profile from stimulated macrophages. Gorczynski, R.M. Eur. J. Immunol. (2001) [Pubmed]
  16. Induction of tolerance-inducing antigen-presenting cells in bone marrow cultures in vitro using monoclonal antibodies to CD200R. Gorczynski, R.M., Chen, Z., Kai, Y., Wong, S., Lee, L. Transplantation (2004) [Pubmed]
  17. Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement. Fallarino, F., Asselin-Paturel, C., Vacca, C., Bianchi, R., Gizzi, S., Fioretti, M.C., Trinchieri, G., Grohmann, U., Puccetti, P. J. Immunol. (2004) [Pubmed]
  18. Molecular mechanisms of CD200 inhibition of mast cell activation. Zhang, S., Cherwinski, H., Sedgwick, J.D., Phillips, J.H. J. Immunol. (2004) [Pubmed]
  19. Blocking CD200-CD200 receptor axis augments NOS-2 expression and aggravates experimental autoimmune uveoretinitis in Lewis rats. Banerjee, D., Dick, A.D. Ocul. Immunol. Inflamm. (2004) [Pubmed]
  20. Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13. Vieites, J.M., de la Torre, R., Ortega, M.A., Montero, T., Peco, J.M., Sánchez-Pozo, A., Gil, A., Suárez, A. Gene (2003) [Pubmed]
  21. Characterization of CD 200-receptor expression in the murine epidermis. Rosenblum, M.D., Woodliff, J.E., Madsen, N.A., McOlash, L.J., Keller, M.R., Truitt, R.L. J. Invest. Dermatol. (2005) [Pubmed]
 
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