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Gene Review

CD200  -  CD200 molecule

Homo sapiens

Synonyms: MOX1, MOX2, MRC, My033, OX-2, ...
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Disease relevance of CD200


Psychiatry related information on CD200

  • MRC to open new CJD research unit.. [7].
  • Clinical assessment was conducted with the MRC score in 28 muscles and a self-evaluation scale (five daily motor activities scored from 0 to 5) [8].
  • Risk factors for Alzheimer's disease and dementia: a case-control study based on the MRC elderly hypertension trial [9].
  • In collaboration with several companies and government departments, the MRC Applied Psychology Unit performed a series of auditory warning studies [10].
  • METHOD: Measures of anxiety and depression and potential alcohol abuse at age 43 were compared in 2085 participants from the MRC National Survey of Health and Development who were either married and never divorced or separated, or who had divorced or separated at least once [11].

High impact information on CD200

  • We also report the results of a project at the MRC UK Mouse Genome Centre targeted at chromosome X. The project produced a YAC-based map containing 619 loci (with 121 loci in common with the Whitehead map and 498 additional loci), providing especially dense coverage of this sex chromosome [12].
  • MRC to fund mouse genome centre [13]?
  • Human genome. MRC follows NIH on patents [14].
  • Spina bifida: MRC folate trials to start at last [15].
  • OX2 (CD200) is a broadly expressed membrane glycoprotein, shown here to be important for regulation of the macrophage lineage [5].

Chemical compound and disease context of CD200


Biological context of CD200

  • The mutagenesis showed that the binding involved the predicted GFCC' face of its N-terminal domain, like that of CD200, suggesting that the interaction evolved from a homotypic interaction [20].
  • Several showed decreased binding to the blocking mAb DX136 and OX108, suggesting close proximity of these epitopes to the CD200 binding site [21].
  • Antibodies to CD200 prevented downregulation of the Th1 response in most B cell CLL samples evaluated, indicating abrogation of the CD200/CD200R interaction can be sufficient to restore the Th1 response [2].
  • B cells from 87 CLL patients exhibited 1.6- to 5.4-fold cell-surface up-regulation of CD200 relative to normal B cells [2].
  • METHODS: A transgenic mouse on a C57BL/6 background, expressing a murine CD200 cDNA genetically linked to a green fluorescent protein tag (GFP) under control of a tetracycline response element (TRE), was mated with a commercial transgenic mouse carrying the reverse tetracycline regulated transactivator gene under control of a human CMV promoter [22].

Anatomical context of CD200


Associations of CD200 with chemical compounds

  • The membrane glycoprotein CD200, which has a widespread but defined distribution and a structurally similar receptor (CD200R) that transmits an inhibitory signal to cells of the hematopoetic lineage, especially myeloid cells, has been characterized [23].
  • Bilateral orchiectomy, performed 1 week before initiation of weekly sc injections of N-nitrosobis(2-oxopropyl)amine (BOP), prevented induction of hyperplastic and neoplastic lesions in the nasal and paranasal cavities of outbred Wistar-derived MRC rats [24].
  • Cross-trial analysis suggests that M7 is comparable to melphalan and prednisone or melphalan, prednisone, and vincristine; that the efficacy of ABCM in the Vth trial and VIth MRC trials is comparable; and that ABCM gave better survival than intermittent melphalan regimens in the prognostic groups analysed [25].
  • Regular inhaled salbutamol and asthma control: the TRUST randomised trial. Therapy Working Group of the National Asthma Task Force and the MRC General Practice Research Framework [26].
  • Presenting white blood cell count and kinetics of molecular remission predict prognosis in acute promyelocytic leukemia treated with all-trans retinoic acid: result of the Randomized MRC Trial [27].

Physical interactions of CD200

  • We report the first characterization of human CD200R (hCD200R) and define its binding characteristics to hCD200 [28].

Regulatory relationships of CD200

  • CONCLUSIONS: We conclude that CD200 triggering of bone-marrow DCs in the absence of CD200R1 engagement induces CD4(+)CD25(+) Treg, and these cloned antigen-specific Treg may have clinical utility [29].

Other interactions of CD200


Analytical, diagnostic and therapeutic context of CD200

  • METHODS: We used a panel of mAbs to mouse and human CD200Fc to compare the rank activities of antibodies for binding (flow cytometric analysis [FACS] or enzyme-linked immunoadsorbent assay [ELISA]) to CD200 with their abilities to augment immune reactivity in MLCs [33].
  • In order to establish protein array technology for the characterization of the weak interactions between leukocyte membrane proteins, we selected the human leukocyte membrane protein CD200 (OX2) and its cell surface receptor (hCD200R) as a model system [21].
  • BACKGROUND: CD200 delivers an immunsuppressive signal that augments allograft survival following interaction with its receptor, CD200R1 [22].
  • Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function [33].
  • Outside the brain, disruption of CD200-CD200 receptor interaction precipitated susceptibility to collagen-induced arthritis (CIA) in mice normally resistant to this disease [5].


  1. Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor. Foster-Cuevas, M., Wright, G.J., Puklavec, M.J., Brown, M.H., Barclay, A.N. J. Virol. (2004) [Pubmed]
  2. Antibodies selected from combinatorial libraries block a tumor antigen that plays a key role in immunomodulation. McWhirter, J.R., Kretz-Rommel, A., Saven, A., Maruyama, T., Potter, K.N., Mockridge, C.I., Ravey, E.P., Qin, F., Bowdish, K.S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. Shiratori, I., Yamaguchi, M., Suzukawa, M., Yamamoto, K., Lanier, L.L., Saito, T., Arase, H. J. Immunol. (2005) [Pubmed]
  4. Cloning and characterization of the human CD200 promoter region. Chen, Z., Marsden, P.A., Gorczynski, R.M. Mol. Immunol. (2006) [Pubmed]
  5. Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Hoek, R.M., Ruuls, S.R., Murphy, C.A., Wright, G.J., Goddard, R., Zurawski, S.M., Blom, B., Homola, M.E., Streit, W.J., Brown, M.H., Barclay, A.N., Sedgwick, J.D. Science (2000) [Pubmed]
  6. CD200 is induced by ERK and is a potential therapeutic target in melanoma. Petermann, K.B., Rozenberg, G.I., Zedek, D., Groben, P., McKinnon, K., Buehler, C., Kim, W.Y., Shields, J.M., Penland, S., Bear, J.E., Thomas, N.E., Serody, J.S., Sharpless, N.E. J. Clin. Invest. (2007) [Pubmed]
  7. MRC to open new CJD research unit... Dove, A. Nat. Med. (1998) [Pubmed]
  8. Intravenous immunoglobulin therapy in multifocal motor neuropathy: a double-blind, placebo-controlled study. Léger, J.M., Chassande, B., Musset, L., Meininger, V., Bouche, P., Baumann, N. Brain (2001) [Pubmed]
  9. Risk factors for Alzheimer's disease and dementia: a case-control study based on the MRC elderly hypertension trial. Prince, M., Cullen, M., Mann, A. Neurology (1994) [Pubmed]
  10. Auditory warning sounds in the work environment. Patterson, R.D. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1990) [Pubmed]
  11. The effects of divorce and separation on mental health in a national UK birth cohort. Richards, M., Hardy, R., Wadsworth, M. Psychological medicine. (1997) [Pubmed]
  12. A YAC-based physical map of the mouse genome. Nusbaum, C., Slonim, D.K., Harris, K.L., Birren, B.W., Steen, R.G., Stein, L.D., Miller, J., Dietrich, W.F., Nahf, R., Wang, V., Merport, O., Castle, A.B., Husain, Z., Farino, G., Gray, D., Anderson, M.O., Devine, R., Horton, L.T., Ye, W., Wu, X., Kouyoumjian, V., Zemsteva, I.S., Wu, Y., Collymore, A.J., Courtney, D.F., Tam, J., Cadman, M., Haynes, A.R., Heuston, C., Marsland, T., Southwell, A., Trickett, P., Strivens, M.A., Ross, M.T., Makalowski, W., Xu, Y., Boguski, M.S., Carter, N.P., Denny, P., Brown, S.D., Hudson, T.J., Lander, E.S. Nat. Genet. (1999) [Pubmed]
  13. MRC to fund mouse genome centre? Younger, J. Nature (1994) [Pubmed]
  14. Human genome. MRC follows NIH on patents. Aldhous, P. Nature (1992) [Pubmed]
  15. Spina bifida: MRC folate trials to start at last. Beardsley, T. Nature (1983) [Pubmed]
  16. Fludarabine and cytosine are less effective than standard ADE chemotherapy in high-risk acute myeloid leukemia, and addition of G-CSF and ATRA are not beneficial: results of the MRC AML-HR randomized trial. Milligan, D.W., Wheatley, K., Littlewood, T., Craig, J.I., Burnett, A.K. Blood (2006) [Pubmed]
  17. Kaposi's sarcoma-associated herpesvirus OX2 glycoprotein activates myeloid-lineage cells to induce inflammatory cytokine production. Chung, Y.H., Means, R.E., Choi, J.K., Lee, B.S., Jung, J.U. J. Virol. (2002) [Pubmed]
  18. Inflammatory myopathy in thyrotoxicosis. Hardiman, O., Molloy, F., Brett, F., Farrell, M. Neurology (1997) [Pubmed]
  19. Effect of oral salbutamol and slow-release aminophylline on exercise tolerance in chronic bronchitis. Leitch, A.G., Morgan, A., Ellis, D.A., Bell, G., Haslett, C., McHardy, G.J. Thorax (1981) [Pubmed]
  20. The CD200 and CD200 receptor cell surface proteins interact through their N-terminal immunoglobulin-like domains. Hatherley, D., Barclay, A.N. Eur. J. Immunol. (2004) [Pubmed]
  21. Analysis of leukocyte membrane protein interactions using protein microarrays. Letarte, M., Voulgaraki, D., Hatherley, D., Foster-Cuevas, M., Saunders, N.J., Barclay, A.N. BMC Biochem. (2005) [Pubmed]
  22. Decreased alloreactivity using donor cells from mice expressing a CD200 transgene under control of a tetracycline-inducible promoter. Yu, K., Chen, Z., Wang, S., Gorczynski, R. Transplantation (2005) [Pubmed]
  23. Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? Minas, K., Liversidge, J. Crit. Rev. Immunol. (2006) [Pubmed]
  24. Prevention of N-nitrosobis(2-oxopropyl)amine-induced nasal cavity tumors in rats by orchiectomy. Pour, P.M., Götz, U. J. Natl. Cancer Inst. (1983) [Pubmed]
  25. Combined chemotherapy with ABCM versus melphalan for treatment of myelomatosis. The Medical Research Council Working Party for Leukaemia in Adults. MacLennan, I.C., Chapman, C., Dunn, J., Kelly, K. Lancet (1992) [Pubmed]
  26. Regular inhaled salbutamol and asthma control: the TRUST randomised trial. Therapy Working Group of the National Asthma Task Force and the MRC General Practice Research Framework. Dennis, S.M., Sharp, S.J., Vickers, M.R., Frost, C.D., Crompton, G.K., Barnes, P.J., Lee, T.H. Lancet (2000) [Pubmed]
  27. Presenting white blood cell count and kinetics of molecular remission predict prognosis in acute promyelocytic leukemia treated with all-trans retinoic acid: result of the Randomized MRC Trial. Burnett, A.K., Grimwade, D., Solomon, E., Wheatley, K., Goldstone, A.H. Blood (1999) [Pubmed]
  28. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. Wright, G.J., Cherwinski, H., Foster-Cuevas, M., Brooke, G., Puklavec, M.J., Bigler, M., Song, Y., Jenmalm, M., Gorman, D., McClanahan, T., Liu, M.R., Brown, M.H., Sedgwick, J.D., Phillips, J.H., Barclay, A.N. J. Immunol. (2003) [Pubmed]
  29. Thymocyte/splenocyte-derived CD4+CD25+Treg stimulated by anti-CD200R2 derived dendritic cells suppress mixed leukocyte cultures and skin graft rejection. Gorczynski, R.M. Transplantation (2006) [Pubmed]
  30. CD200 maintains microglial potential to migrate in adult human retinal explant model. Carter, D.A., Dick, A.D. Curr. Eye Res. (2004) [Pubmed]
  31. Gene expression profiling gets to the root of human hair follicle stem cells. Cotsarelis, G. J. Clin. Invest. (2006) [Pubmed]
  32. mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging. Frank, M.G., Barrientos, R.M., Biedenkapp, J.C., Rudy, J.W., Watkins, L.R., Maier, S.F. Neurobiol. Aging (2006) [Pubmed]
  33. Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function. Chen, D.X., Gorczynski, R.M. Transplantation (2005) [Pubmed]
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