Gene Review:
MEF2C - myocyte enhancer factor 2C
Homo sapiens
Synonyms:
C5DELq14.3, DEL5q14.3, Myocyte-specific enhancer factor 2C
- Myocyte-specific enhancer binding factor 2C expression in gerbil brain following global cerebral ischemia. Speliotes, E.K., Kowall, N.W., Shanti, B.F., Kosofsky, B., Finklestein, S.P., Leifer, D. Neuroscience (1996)
- GATA-4 and MEF2C transcription factors control the tissue-specific expression of the alphaT-catenin gene CTNNA3. Vanpoucke, G., Goossens, S., De Craene, B., Gilbert, B., van Roy, F., Berx, G. Nucleic Acids Res. (2004)
- Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Han, J., Jiang, Y., Li, Z., Kravchenko, V.V., Ulevitch, R.J. Nature (1997)
- Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. Lynch, J., Guo, L., Gelebart, P., Chilibeck, K., Xu, J., Molkentin, J.D., Agellon, L.B., Michalak, M. J. Cell Biol. (2005)
- GATA-dependent recruitment of MEF2 proteins to target promoters. Morin, S., Charron, F., Robitaille, L., Nemer, M. EMBO J. (2000)
- p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps. Wu, Z., Woodring, P.J., Bhakta, K.S., Tamura, K., Wen, F., Feramisco, J.R., Karin, M., Wang, J.Y., Puri, P.L. Mol. Cell. Biol. (2000)
- Phosphorylation and alternative pre-mRNA splicing converge to regulate myocyte enhancer factor 2C activity. Zhu, B., Gulick, T. Mol. Cell. Biol. (2004)
- Big mitogen-activated kinase regulates multiple members of the MEF2 protein family. Kato, Y., Zhao, M., Morikawa, A., Sugiyama, T., Chakravortty, D., Koide, N., Yoshida, T., Tapping, R.I., Yang, Y., Yokochi, T., Lee, J.D. J. Biol. Chem. (2000)
- Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23. Hobson, G.M., Krahe, R., Garcia, E., Siciliano, M.J., Funanage, V.L. Genomics (1995)
- Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation. Ma, K., Chan, J.K., Zhu, G., Wu, Z. Mol. Cell. Biol. (2005)
- SOX18 directly interacts with MEF2C in endothelial cells. Hosking, B.M., Wang, S.C., Chen, S.L., Penning, S., Koopman, P., Muscat, G.E. Biochem. Biophys. Res. Commun. (2001)
- Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes. Swanson, B.J., Jäck, H.M., Lyons, G.E. Mol. Immunol. (1998)
- Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity. Molkentin, J.D., Li, L., Olson, E.N. J. Biol. Chem. (1996)
- p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor. Zetser, A., Gredinger, E., Bengal, E. J. Biol. Chem. (1999)
- Downregulation of myocardial myocyte enhancer factor 2C and myocyte enhancer factor 2C-regulated gene expression in diabetic patients with nonischemic heart failure. Razeghi, P., Young, M.E., Cockrill, T.C., Frazier, O.H., Taegtmeyer, H. Circulation (2002)
- HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. Wang, A.H., Bertos, N.R., Vezmar, M., Pelletier, N., Crosato, M., Heng, H.H., Th'ng, J., Han, J., Yang, X.J. Mol. Cell. Biol. (1999)
- Functional interaction between peroxisome proliferator-activated receptors-alpha and Mef-2C on human carnitine palmitoyltransferase 1beta (CPT1beta) gene activation. Baldán, A., Relat, J., Marrero, P.F., Haro, D. Nucleic Acids Res. (2004)
- Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C. Wilson-Rawls, J., Molkentin, J.D., Black, B.L., Olson, E.N. Mol. Cell. Biol. (1999)
- Regulation of the MEF2 family of transcription factors by p38. Zhao, M., New, L., Kravchenko, V.V., Kato, Y., Gram, H., di Padova, F., Olson, E.N., Ulevitch, R.J., Han, J. Mol. Cell. Biol. (1999)
- SMRTE inhibits MEF2C transcriptional activation by targeting HDAC4 and 5 to nuclear domains. Wu, X., Li, H., Park, E.J., Chen, J.D. J. Biol. Chem. (2001)
- Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation. Okamoto, S., Krainc, D., Sherman, K., Lipton, S.A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. Yang, S.H., Galanis, A., Sharrocks, A.D. Mol. Cell. Biol. (1999)
- Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis. Paroni, G., Mizzau, M., Henderson, C., Del Sal, G., Schneider, C., Brancolini, C. Mol. Biol. Cell (2004)
- BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. Kato, Y., Kravchenko, V.V., Tapping, R.I., Han, J., Ulevitch, R.J., Lee, J.D. EMBO J. (1997)
- hMusTRD1alpha1 represses MEF2 activation of the troponin I slow enhancer. Polly, P., Haddadi, L.M., Issa, L.L., Subramaniam, N., Palmer, S.J., Tay, E.S., Hardeman, E.C. J. Biol. Chem. (2003)
- Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1. Krainc, D., Bai, G., Okamoto, S., Carles, M., Kusiak, J.W., Brent, R.N., Lipton, S.A. J. Biol. Chem. (1998)
- Myocyte-specific enhancer binding factor 2C expression in human brain development. Leifer, D., Golden, J., Kowall, N.W. Neuroscience (1994)
- Molecular cloning and developmental expression patterns of the MyoD and MEF2 families of muscle transcription factors in the carp. Kobiyama, A., Nihei, Y., Hirayama, Y., Kikuchi, K., Suetake, H., Johnston, I.A., Watabe, S. J. Exp. Biol. (1998)
- Hybrid cardiomyocytes derived by cell fusion in heterotopic cardiac xenografts. Dedja, A., Zaglia, T., Dall'Olmo, L., Chioato, T., Thiene, G., Fabris, L., Ancona, E., Schiaffino, S., Ausoni, S., Cozzi, E. FASEB J. (2006)