The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Choristoma


High impact information on Choristoma

  • This inability of diabetic EPCs to respond to SDF-1 may contribute to aberrant tissue vascularization and endothelial repair in diabetic patients [6].
  • The serpinopathies result from conformational transitions in members of the serine proteinase inhibitor superfamily with aberrant tissue deposition or loss of function [7].
  • The ectopic tissue buds ventrolaterally into the adjacent mesenchyme, and less extensively into the tracheal lumen, forming follicle-like structures that accumulate thyroglobulin [8].
  • Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation [9].
  • In biodistribution analyses the contamination can lead to false-negative results by masking low-level lacZ expression in target and ectopic tissues, and false-positive results if sufficient controls are not used [10].

Chemical compound and disease context of Choristoma


Anatomical context of Choristoma


Gene context of Choristoma

  • In vivo, MMP-3 mRNA was detectable at all times in ectopic tissues but not in eutopic uterine tissues, whereas MMP-2 and TIMP-1 were ubiquitously expressed at all times in both tissues [21].
  • Aberrant tissue expression of MHC antigens may be more widespread than has been previously recognized in diseases mediated by immune mechanisms [22].
  • Non-GH promoters for fusion genes allowed novel regulation of GH production in ectopic tissues, including the kidney, liver and gut [23].
  • Aged MAM-treated rats may thus offer a good model for studying age-related monoaminergic changes in the cortical heterotopic tissue of human cortical malformations [19].
  • Taken together, these results suggest that the absence of sufficient mammary-specific regulatory elements in the BLG promoter sequences and/or the juxtaposition of the BLG promoter with the HSA coding sequences leads to novel tissue- and cell-specific expression in ectopic tissues of transgenic mice [24].

Analytical, diagnostic and therapeutic context of Choristoma


  1. Selective loss of hippocampal granule cells following adrenalectomy: implications for spatial memory. Conrad, C.D., Roy, E.J. J. Neurosci. (1993) [Pubmed]
  2. Posterior scleral choristoma in the organoid nevus syndrome (linear nevus sebaceus of Jadassohn). Traboulsi, E.I., Zin, A., Massicotte, S.J., Kosmorsky, G., Kotagal, P., Ellis, F.D. Ophthalmology (1999) [Pubmed]
  3. Intrasellar neuronal choristoma associated with growth hormone-producing pituitary adenoma containing amyloid deposits. Iwase, T., Nishizawa, S., Baba, S., Hinokuma, K., Sugimura, H., Nakamura, S., Uemura, K., Shirasawa, H., Kino, I. Hum. Pathol. (1995) [Pubmed]
  4. Implications of local angiotensin production in cardiovascular physiology and pharmacology. Dzau, V.J. Am. J. Cardiol. (1987) [Pubmed]
  5. The role of heterotopic gastric mucosa with or without colonization of Helicobacter pylori upon the diverse symptomatology of Meckel's diverticulum in children. Oğuzkurt, P., Talim, B., Tanyel, F.C., Cağlar, M., Senocak, M.E., Büyükpamukçu, N. Turk. J. Pediatr. (2001) [Pubmed]
  6. Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes. Segal, M.S., Shah, R., Afzal, A., Perrault, C.M., Chang, K., Schuler, A., Beem, E., Shaw, L.C., Li Calzi, S., Harrison, J.K., Tran-Son-Tay, R., Grant, M.B. Diabetes (2006) [Pubmed]
  7. Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies. Onda, M., Belorgey, D., Sharp, L.K., Lomas, D.A. J. Biol. Chem. (2005) [Pubmed]
  8. Genetic deletion of sonic hedgehog causes hemiagenesis and ectopic development of the thyroid in mouse. Fagman, H., Grände, M., Gritli-Linde, A., Nilsson, M. Am. J. Pathol. (2004) [Pubmed]
  9. Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation. Osouda, S., Nakamura, Y., de Saint Phalle, B., McConnell, M., Horigome, T., Sugiyama, S., Fisher, P.A., Furukawa, K. Dev. Biol. (2005) [Pubmed]
  10. Escherichia coli DNA contamination in AmpliTaq Gold polymerase interferes with TaqMan analysis of lacZ. Koponen, J.K., Turunen, A.M., Ylä-Herttuala, S. Mol. Ther. (2002) [Pubmed]
  11. Low aromatase activity in microsomes from complete hydatidiform mole. Genti-Raimondi, S., Alvarez, C.I., Patrito, L.C., Flury, A. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  12. Gonadal and adrenal catheterization during adrenal suppression and gonadal stimulation in a patient with bilateral testicular tumors and congenital adrenal hyperplasia. Combes-Moukhovsky, M.E., Kottler, M.L., Valensi, P., Boudou, P., Sibony, M., Attali, J.R. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  13. Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue. Fang, Z., Yang, S., Gurates, B., Tamura, M., Simpson, E., Evans, D., Bulun, S.E. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  14. Integrins alpha 3 and alpha 6 are differentially expressed in endometrium and endometriosis. Rai, V., Hopkisson, J., Kennedy, S., Bergqvist, A., Barlow, D.H., Mardon, H.J. J. Pathol. (1996) [Pubmed]
  15. Pleomorphic hamartoma of the subcutis: a lesion with possible myogenous and neural lineages. Shitabata, P.K., Ritter, J.H., Fitzgibbon, J.F., Dehner, L.P., Wick, M.R. J. Cutan. Pathol. (1995) [Pubmed]
  16. Unusual cystic epithelial choristoma in a celiac lymph node. Carr, R.F., Tang, C.K., Carrozza, M.J., Rodriguez, F.C. Hum. Pathol. (1987) [Pubmed]
  17. Phakomatous choristoma of the eyelid. Immunohistochemical and electron microscopic observations. Rosenbaum, P.S., Kress, Y., Slamovits, T.L., Font, R.L. Ophthalmology (1992) [Pubmed]
  18. Fibromodulin-null murine knee joints display increased incidences of osteoarthritis and alterations in tissue biochemistry. Gill, M.R., Oldberg, A., Reinholt, F.P. Osteoarthr. Cartil. (2002) [Pubmed]
  19. Degeneration of monoaminergic fibers in the aged micrencephalic rat. Watabe, Y., Yoshimoto, K., Eguchi, M., Ueda, S. Neurosci. Lett. (2005) [Pubmed]
  20. Cartilaginous choristoma deep in the upper midline oral vestibule. Matsushita, K., Tahara, M., Sato, H., Nakamura, E., Fujiwara, T. The British journal of oral & maxillofacial surgery. (2004) [Pubmed]
  21. Differential regulation of matrix metalloproteinase-3 gene expression in endometriotic lesions compared with endometrium. Cox, K.E., Piva, M., Sharpe-Timms, K.L. Biol. Reprod. (2001) [Pubmed]
  22. Expression of MHC class I determinants on erythrocytes of SLE patients. Giles, C.M., Walport, M.J., David, J., Darke, C. Clin. Exp. Immunol. (1987) [Pubmed]
  23. Insertion, expression and physiology of growth-regulating genes in ruminants. Rexroad, C.E., Hammer, R.E., Behringer, R.R., Palmiter, R.D., Brinster, R.L. J. Reprod. Fertil. Suppl. (1990) [Pubmed]
  24. Ectopic expression of beta-lactoglobulin/human serum albumin fusion genes in transgenic mice: hormonal regulation and in situ localization. Barash, I., Faerman, A., Ratovitsky, T., Puzis, R., Nathan, M., Hurwitz, D.R., Shani, M. Transgenic Res. (1994) [Pubmed]
  25. Radioiodine uptake following thyroidectomy for thyroid cancer. Recurrence or ectopic tissue? Sud, A.M., Gross, M.D. Clinical nuclear medicine. (1991) [Pubmed]
WikiGenes - Universities