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Gene Review

Cd79b  -  CD79B antigen

Mus musculus

Synonyms: B-cell antigen receptor complex-associated protein beta chain, B-cell-specific glycoprotein B29, B29, Ig-beta, Igb, ...
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Disease relevance of Cd79b

  • To explore the role of ITAM in signaling for B cell death (apoptosis), we transfected CH31 cells, an immature B lymphoma cell line, with expression vectors encoding for the CD8 extracellular/transmembrane domains and the cytoplasmic signal-transducing domain (ITAM) of Ig alpha or Ig beta, respectively [1].
  • Five acquired immunodeficiency syndrome (AIDS)-MLs and ten SCID-EBV-positive BMLs were first analysed by immunohistochemistry for the expression of Mb-1, B29 and Lyn [2].
  • In SCID-EBV-positive BMLs, Mb-1 was down regulated in six of ten, B29 in nine of ten and Lyn in six of ten, whereas no down-regulation was noted in eight EBV-free B MLs that were also maintained in SCID mice [2].
  • To dissect the mechanisms by which each tail contributes to development in vivo, Igbeta(-/-) mice were reconstituted with retroviruses encoding either wild-type Igbeta, an Igbeta molecule lacking a cytoplasmic tail (Igbeta(deltaC)) or one in which the cytoplasmic tail was derived from Igalpha (Igbeta(Calpha)) [3].
  • Iga, received spleen cells from a congenic strain bearing another allotype, Igb, and weekly injections with Iga-coated pertussis [4].

High impact information on Cd79b

  • Hence, B-lineage commitment is determined neither by immunoglobulin DJ rearrangement nor by the expression of E2A, EBF, lambda5, VpreB, Igalpha and Igbeta [5].
  • This inhibition is directly coupled to signalling mediated through Ig-alpha and Ig-beta as evidenced by chimaeric IgM/alpha and IgM/beta molecules [6].
  • We now show that the IgM molecule is non-covalently associated in the membrane of B cells with two proteins of relative molecular mass 34,000 (Mr 34 K; IgM-alpha) and 39 K (Ig-beta) which form a disulphide-linked heterodimer [7].
  • The cytoplasmic domain of Ig beta is sufficient to induce these early antigen-independent events by a mechanism that requires conserved tyrosine residues in this protein [8].
  • In contrast, Ig beta targets antigen towards a minor population of recycling MHC class II molecules, located in transferrin receptor-containing endosomes [9].

Chemical compound and disease context of Cd79b


Biological context of Cd79b


Anatomical context of Cd79b

  • Thus, the cross-linking of Ig beta on proB cells appears to elicit differentiation signals analogous to those delivered by the preB cell receptor in normal B cell development [15].
  • Cross-lineage expression of Ig-beta (B29) in thymocytes: positive and negative gene regulation to establish T cell identity [16].
  • Furthermore, ectopic expression of EBF in HeLa cells activated a B29 promoter-controlled reporter construct 13-fold and induced a low level of expression from the endogenous B29 gene [12].
  • Affinity-purified anti-MB-1 antibody coprecipitated mu chain/20-kDa/15-kDa proteins together with monomer MB-1 and Ig-alpha/Ig-beta heterodimer components from digitonin lysates of the pre-B cell line 18.81 [17].
  • Ligand-induced BCR association with detergent-resistant plasma membrane compartments (lipid rafts) has been argued to be essential for initiating and/or sustaining Igalpha/Igbeta-dependent BCR signaling [18].

Associations of Cd79b with chemical compounds

  • One mutant mu chain, in which two polar transmembrane residues (Tyr587, Ser588) are replaced with valine, fails to associate with Ig alpha and Ig beta and is incapable of transducing signals as a result of mIg cross-linking [19].
  • To examine the function of Igbeta ITAM tyrosine resides in mature B cells in vivo, we exchanged these residues for alanine by gene targeting (Igbeta(AA)) [20].
  • Ig beta Delta C mice differ from Ig alpha Delta C mice in that they show little impairment in early B cell development and they produce immature B cells that respond normally to BCR cross-linking as determined by Ca(2+) flux [14].
  • We found that extraction with Triton X-100 revealed an additional pair of 52- to 58-kDa heterodimers, where B29 was disulfide-bonded to a protein of approximately 23 kDa [21].
  • We show that in the presence of the reducing agent beta-mercaptoethanol the m mu, m delta, and m gamma heavy chains remain selectively associated with the B29 members [22].

Physical interactions of Cd79b


Enzymatic interactions of Cd79b

  • Lck phosphorylated both of the tyrosines in the Ig-beta AgR homology motif and one of the two tyrosines in the Ig-alpha AgR homology motif [23].

Regulatory relationships of Cd79b


Other interactions of Cd79b

  • The Ig alpha/Igbeta heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation [15].
  • These data suggest that the B29 gene is a genetic target for EBF in early B-cell development [12].
  • The ability to interact directly with E47 was shared by the promoters controlling the human mb-1 and B29 genes [27].
  • To understand the function of B cell antigen receptor (BCR)-related complex on pre-B cells (pre-BCR, Vpre-B/lambda 5/mu heavy chain/Ig-alpha/Ig-beta), we examined pre-BCR- and BCR-mediated signaling events in human and mouse pre-B (Nalm-6, 697, NFS-5), immature B (IgM+ Daudi, WEHI-231) and mature B (IgM+ IgD+ BALL1) cell lines [28].
  • In these mice, Cre-mediated recombination at the fas, Igbeta, IgH, and Rosa26 loci occurred in GC B cells as early as 4 days after immunization with T cell-dependent antigens and involved >85% of GC B cells at the peak of the GC reaction [29].

Analytical, diagnostic and therapeutic context of Cd79b


  1. Immunoreceptor tyrosine-based activation motif is required to signal pathways of receptor-mediated growth arrest and apoptosis in murine B lymphoma cells. Yao, X.R., Flaswinkel, H., Reth, M., Scott, D.W. J. Immunol. (1995) [Pubmed]
  2. Down-regulation of membrane immunoglobulin-associated proteins, MB-1, B29 and Lyn, in AIDS-lymphomas and related conditions. Mori, S., Takanashi, M., Shiota, M., Choi, S.H., Yamanashi, Y., Watanabe, T., Koike, M. Virchows Arch. (1994) [Pubmed]
  3. Selection of B lymphocytes in the periphery is determined by the functional capacity of the B cell antigen receptor. Wang, L.D., Lopes, J., Cooper, A.B., Dang-Lawson, M., Matsuuchi, L., Clark, M.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Continuous production of anti-host IgG antibodies contained in circulating IgG-anti-IgG complexes. Grace, S.A., Elson, C.J. Immunology (1982) [Pubmed]
  5. Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors. Rolink, A.G., Nutt, S.L., Melchers, F., Busslinger, M. Nature (1999) [Pubmed]
  6. A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signalling. Muta, T., Kurosaki, T., Misulovin, Z., Sanchez, M., Nussenzweig, M.C., Ravetch, J.V. Nature (1994) [Pubmed]
  7. Molecular components of the B-cell antigen receptor complex of the IgM class. Hombach, J., Tsubata, T., Leclercq, L., Stappert, H., Reth, M. Nature (1990) [Pubmed]
  8. The role of Ig beta in precursor B cell transition and allelic exclusion. Papavasiliou, F., Misulovin, Z., Suh, H., Nussenzweig, M.C. Science (1995) [Pubmed]
  9. Role of B cell receptor Ig alpha and Ig beta subunits in MHC class II-restricted antigen presentation. Bonnerot, C., Lankar, D., Hanau, D., Spehner, D., Davoust, J., Salamero, J., Fridman, W.H. Immunity (1995) [Pubmed]
  10. B29 gene products complex with immunoglobulins on B lymphocytes. Ishihara, K., Wood, W.J., Damore, M., Hermanson, G.G., Wall, R., Kincade, P.W. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  11. Silencer elements controlling the B29 (Igbeta) promoter are neither promoter- nor cell-type-specific. Malone, C.S., Omori, S.A., Wall, R. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  12. The B29 (immunoglobulin beta-chain) gene is a genetic target for early B-cell factor. Akerblad, P., Rosberg, M., Leanderson, T., Sigvardsson, M. Mol. Cell. Biol. (1999) [Pubmed]
  13. Signaling-defective mutants of the B lymphocyte antigen receptor fail to associate with Ig-alpha and Ig-beta/gamma. Grupp, S.A., Campbell, K., Mitchell, R.N., Cambier, J.C., Abbas, A.K. J. Biol. Chem. (1993) [Pubmed]
  14. B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta. Reichlin, A., Hu, Y., Meffre, E., Nagaoka, H., Gong, S., Kraus, M., Rajewsky, K., Nussenzweig, M.C. J. Exp. Med. (2001) [Pubmed]
  15. The Ig alpha/Igbeta heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation. Nagata, K., Nakamura, T., Kitamura, F., Kuramochi, S., Taki, S., Campbell, K.S., Karasuyama, H. Immunity (1997) [Pubmed]
  16. Cross-lineage expression of Ig-beta (B29) in thymocytes: positive and negative gene regulation to establish T cell identity. Wang, H., Diamond, R.A., Rothenberg, E.V. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  17. Cross-linking of B cell receptor-related MB-1 molecule induces protein tyrosine phosphorylation in early B lineage cells. Matsuo, T., Nomura, J., Kuwahara, K., Igarashi, H., Inui, S., Hamaguchi, M., Kimoto, M., Sakaguchi, N. J. Immunol. (1993) [Pubmed]
  18. Ig alpha/Ig beta complexes generate signals for B cell development independent of selective plasma membrane compartmentalization. Fuentes-Pananá, E.M., Bannish, G., van der Voort, D., King, L.B., Monroe, J.G. J. Immunol. (2005) [Pubmed]
  19. Molecular mechanisms that control expression of the B lymphocyte antigen receptor complex. Grupp, S.A., Mitchell, R.N., Schreiber, K.L., McKean, D.J., Abbas, A.K. J. Exp. Med. (1995) [Pubmed]
  20. Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization. Gazumyan, A., Reichlin, A., Nussenzweig, M.C. J. Exp. Med. (2006) [Pubmed]
  21. Multiple B29 containing complexes on murine B lymphocytes. Common and stage-restricted Ig-associated polypeptide chains. Ishihara, K., Wood, W.J., Wall, R., Sakaguchi, N., Michnoff, C., Tucker, P.W., Kincade, P.W. J. Immunol. (1993) [Pubmed]
  22. Evidence for a direct physical interaction of membrane IgM, IgD, and IgG with the B29 gene product. Lankester, A.C., van Schijndel, G.M., Frommé, J., Cordell, J.L., van Lier, R.A., van Noesel, C.J. J. Immunol. (1994) [Pubmed]
  23. Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes. Gold, M.R., Chiu, R., Ingham, R.J., Saxton, T.M., van Oostveen, I., Watts, J.D., Affolter, M., Aebersold, R. J. Immunol. (1994) [Pubmed]
  24. Deletion of immunoglobulin beta in developing B cells leads to cell death. Meffre, E., Nussenzweig, M.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  25. Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation. Rowley, R.B., Burkhardt, A.L., Chao, H.G., Matsueda, G.R., Bolen, J.B. J. Biol. Chem. (1995) [Pubmed]
  26. Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells. Jimi, E., Phillips, R.J., Rincon, M., Voll, R., Karasuyama, H., Flavell, R., Ghosh, S. Int. Immunol. (2005) [Pubmed]
  27. The human V-preB promoter is a target for coordinated activation by early B cell factor and E47. Gisler, R., Sigvardsson, M. J. Immunol. (2002) [Pubmed]
  28. Cross-linking of B cell antigen receptor-related structure of pre-B cell lines induces tyrosine phosphorylation of p85 and p110 subunits and activation of phosphatidylinositol 3-kinase. Kuwahara, K., Kawai, T., Mitsuyoshi, S., Matsuo, Y., Kikuchi, H., Imajoh-Ohmi, S., Hashimoto, E., Inui, S., Cooper, M.D., Sakaguchi, N. Int. Immunol. (1996) [Pubmed]
  29. Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Casola, S., Cattoretti, G., Uyttersprot, N., Koralov, S.B., Segal, J., Hao, Z., Waisman, A., Egert, A., Ghitza, D., Rajewsky, K. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  30. Regulation of an early developmental checkpoint in the B cell pathway by Ig beta. Gong, S., Nussenzweig, M.C. Science (1996) [Pubmed]
  31. Monomeric and oligomeric complexes of the B cell antigen receptor. Schamel, W.W., Reth, M. Immunity (2000) [Pubmed]
  32. IgM antigen receptor complex contains phosphoprotein products of B29 and mb-1 genes. Campbell, K.S., Hager, E.J., Friedrich, R.J., Cambier, J.C. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
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